Basic study concerning the involvement of oxidative stress in the pathogenesis of menopausal depression

Research Project

Project/Area Number	15K10706
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Obstetrics and gynecology
Research Institution	Tokyo Medical and Dental University
Principal Investigator	TERAUCHI Masakazu 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教授 (90361708)
Co-Investigator(Kenkyū-buntansha)	久保田俊郎東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50126223)
Research Collaborator	HIROSE Asuka ODAI Tamami
Project Period (FY)	2015-04-01 – 2019-03-31
Project Status	Completed (Fiscal Year 2018)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	更年期うつ症状 / 酸化ストレス / 更年期障害 / 更年期症状 / うつ病 / うつ症状 / うつ状態
Outline of Final Research Achievements	Clinical study: We found that the severity of depressive symptoms was the sole factor that was associated with urinary oxidative stress marker concentration in menopausal women using cross-sectional multivariate logistic regression analysis. Basic study: Contrary to our expectations, we found that the depression-like symptoms evaluated by forced swim test decreased in ovariectomized mice. Laboratory tests showed that anti-oxidant potential (BAP) was higher, and oxidative stress markers (nitrotyrosine and MDA) were lower, in ovariectomized mice than sham-operated mice.
Academic Significance and Societal Importance of the Research Achievements	臨床研究：更年期女性のうつ症状が酸化ストレスと独立に関連する唯一の因子であることが明らかになった。周閉経期に増加する酸化ストレスが更年期うつ症状の主要な寄与因子である可能性が示唆された。基礎研究：本動物実験によって得られた当初の予想に反する結果からは、強制水泳試験のような外的ストレスを加えた場合に発生する体内酸化ストレスの程度が偽手術マウスと卵巣摘出マウスでは異なることが示唆された。