• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Clarification of molecular biological feature of Mullerian endometrioid adenocarcinoma and establishment of differentiation of its origin

Research Project

Project/Area Number 15K10707
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNiigata University

Principal Investigator

YAMAGUCHI Masayuki  新潟大学, 医歯学総合病院, 講師 (20529771)

Co-Investigator(Kenkyū-buntansha) 吉原 弘祐  新潟大学, 医歯学系, 助教 (40547535)
関根 正幸  新潟大学, 医歯学総合病院, 助教 (70345502)
榎本 隆之  新潟大学, 医歯学系, 教授 (90283754)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsミュラー管由来類内膜腺癌 / 類内膜癌関連遺伝子 / Endometrioid carcinoma / Transcriptome / translational research / cancer / mutation
Outline of Final Research Achievements

Microarray analyses were performed between uterine corpus endometrioid adenocarcinoma group (n=73), uterine corpus serous adenocarcinoma group (n=12), ovarian endometorioid adenocarcinoma group (n=20), and ovarian serous adenocarcinoma group (n=243). Consequently, 135 genes associated with ovarian endometorioid adenocarcinoma and 102 genes associated with uterine corpus endometrioid adenocarcinoma were extracted. We compared gene expression profiling of ovarian endometrioid adenocarcinoma with that of uterine corpus endometrioid adenocarcinoma and validated reproducibility using TCGA database. Finally, difference in degree of PI3K-AKT pathway activation between ovarian endometrioid adenocarcinoma and uterine corpus endometrioid adenocarcinoma was revealed with single sample gene set enrichmint analysis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2018 2017

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results)

  • [Journal Article] Malignancy during pregnancy in Japan: an exceptional opportunity for early diagnosis.2018

    • Author(s)
      Sekine M, Kobayashi Y, Tabata T, Sudo T, Nishimura R, Matsuo K, Grubbs BH, Enomoto T, Ikeda T.
    • Journal Title

      BMC Pregnancy Childbirth.

      Volume: 18(1) Issue: 1 Pages: 50-50

    • DOI

      10.1186/s12884-018-1678-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions2018

    • Author(s)
      Tamura R, Yoshihara K, Saito T, Ishimura R, Martinez-Ledesma JE, Xin H, Ishiguro T, Mori Y, Yamawaki K, Suda K, Sato S, Itamochi H, Motoyama T, Aoki Y, Okuda S, Casingal CR, Nakaoka H, Inoue I, Verhaak RGW, Komatsu M, Enomoto T.
    • Journal Title

      Oncogenesis

      Volume: 7 Issue: 1 Pages: 4-4

    • DOI

      10.1038/s41389-017-0018-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer2017

    • Author(s)
      Yamawaki K, Ishiguro T, Mori Y, Yoshihara K, Suda K, Tamura R, Yamaguchi M, Sekine M, Kashima K, Higuchi M, Fujii M, Okamoto K, Enomoto T
    • Journal Title

      Cancer Sci.

      Volume: 108 Issue: 4 Pages: 632

    • DOI

      10.1111/cas.13196

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi