Analysis of circulating cancer stem cells in endometrial cancer
| Project/Area Number |
15K10708
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤原 浩 金沢大学, 医学系, 教授 (30252456)
尾崎 聡 金沢大学, 大学病院, その他 (40401921)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Endometrial cancer / Cancer stem cells / p53 / ERβ / 子宮内膜癌 / 癌幹細胞 / CD133 |
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| Outline of Final Research Achievements |
We examined the immunohistochemical expression profiles of p53 and estrogen receptor (ER) β proteins in patients with endometrial endometrioid carcinoma who underwent surgical treatment at our hospital (n = 154). By multivariate analysis, we found that histological grades, detection of immunoreactive p53 and high expression of ERβ (high-ERβ) were independently associated with metastasis and/or recurrence. Among these parameters, the sensitivity and negative predictive values of high-ERβ were very high (up to 100%). The disease- free survival of patients who were double-positive for p53-stained and high-ERβ was significantly shorter than that in other patients. These results suggess that double-positivity for p53-stained and high-ERβ may provide a promising clinical indicator to predict the risk of progression in endomterial cancer. Furthermore, p53 and ERβ expression may be associated with cancer stem cells (CSCs), especially CD133 and CD117 CSC markers.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Detection of hypermutated human papillomavirus type 16 genome by Next-Generation Sequencing.2015
Author(s)
Wakae K, Aoyama S, Wang Z, Kitamura K, Liu G, Monjurul AM, Koura M, Imayasu M, Sakamoto N, Nakamura M, Kyo S, Kondo S, Fujiwara H, Yoshizaki T, Kukimoto I, Yamaguchi K, Shigenobu S, Nishiyama T, Muramatsu M.
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Journal Title
Virology
Volume: 485
Pages: 460-466
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Tamoxifen-induced ovarian hyperstimulation during premenopausal hormonal therapy for breast cancer in Japanese women.2015
Author(s)
Yamazaki R, Inokuchi M, Ishikawa S, Myojo S, Iwadare J, Bono Y, Mizumoto Y, Nakamura M,Takakura M, Iizuka T, Ohta T, Fujiwara H.
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Journal Title
Springerplus
Volume: 4
Issue: 1
Pages: 425-429
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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