The search for natural history and factors involved in malignant transformation of lobular endocervical glandular hyperplasia (LEGH)
| Project/Area Number |
15K10712
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Shinshu University |
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Principal Investigator |
Takatsu Akiko 信州大学, 医学部附属病院, 特任研究員 (90447730)
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| Co-Investigator(Kenkyū-buntansha) |
塩沢 丹里 信州大学, 学術研究院医学系, 教授 (20235493)
宮本 強 信州大学, 学術研究院医学系, 准教授 (70418721)
安藤 大史 信州大学, 医学部附属病院, 助教(診療) (80722925)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 分葉状頸管腺過形成 / 胃型粘液性癌 / 子宮頸癌 / 頸管細胞診 / 核磁気共鳴画像 / 胃型ムチン / CTNNB1 / αGlcNAc / 悪性腺腫 / 胃型腺癌 / 臨床診断 / 全エクソン解析 / 子宮頸管細胞診 / 胃型粘液 / MRI |
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| Outline of Final Research Achievements |
Of 43 cases of lobular endocervical glandular hyperplasia (LEGH) with more than 12 months of the observation period, 2 cases were progressing to "LEGH with atypia" and 1 case was to "gastric-type mucinous carcinoma (GAS)". These cases suggest that the enlarging cervical lesion and the aggravation of cytology may be the important signs suggesting a malignant transformation of LEGH. Membrane expression of the CTNNB1 protein involved in intercellular adhesion was significantly attenuated in GAS compared with LEGH. This CTNNB1-downregulation may have an important role in the development of GAS. Expression of αGlcNAc in gastric mucin and α4GnT, a glycosyltransferase involved in the αGlcNAc production, is specifically observed in LEGH and GAS; however, those expressions were significantly attenuated in GAS compared with LEGH. The attenuation of αGlcNAc and α4GnT expression may be a useful marker supporting the distinguishment of GAS from LEGH.
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Report
(4 results)
Research Products
(9 results)
