Function analysis of new molecular target RSF-1 for uterine leiomyosarcoma

• Project/Area Number: 15K10718
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Shimane University
• Principal Investigator: Ishikawa Masako 島根大学, 医学部, 助教 (50467718)
• Co-Investigator(Kenkyū-buntansha): 京 哲 島根大学, 医学部, 教授 (50272969) ; 中山 健太郎 島根大学, 医学部, 准教授 (70346401)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: RSF-1 / 子宮悪性腫瘍 / 分子標的治療 / 子宮肉腫 / 子宮体癌

Outline of Final Research Achievements

We investigated whether oncogene RSF-1 would have the ability as molecular target therapy for uterine leiomyosarcoma and uterine carcinoma.
We examined the association between expression of RSF-1 protein and clinicopathological factor for patients with malignant uterine tumor. There was no correlation between overexpression of RSF-1 protein and patient’s progression free survival and overall survival. We also demonstrated that there was correlation between RSF-1 and ability of growth and invasion in uterine malignant tumors. So, we considered that RSF-1 would influence the ability of tumor growth and tumor metastasis. We considered it might be possible that RSF-1 would be the target of treatment for uterine malignant diseases.

Research Products

• [Journal Article] Affinity-purified DNA-based mutation profiles of endometriosis-related ovarian neoplasms in Japanese patients. (2018)
  • Author(s): Ishikawa M, Nakayama K, Nakamura K, Ono R, Sanuki K, Yamashita H, Ishibashi T, Minamoto T, Iida K, Razia S, Ishikawa N, Kyo S.
  • Journal Title: Oncotarget Volume: 9(19) Issue: 19 Pages: 14754-14763
  • DOI: 10.18632/oncotarget.24546
  • Peer Reviewed / Open Access
• [Journal Article] Lynch Syndrome-Related Clear Cell Carcinoma of the Cervix: A Case Report (2018)
  • Author(s): Nakamura Kohei、Nakayama Kentaro、Minamoto Toshiko、Ishibashi Tomoka、Ohnishi Kaori、Yamashita Hitomi、Ono Ruriko、Sasamori Hiroki、Razia Sultana、Hossain Mohammad Mahmud、Kamrunnahar Shanta、Ishikawa Masako、Ishikawa Noriyoshi、Kyo Satoru
  • Journal Title: International Journal of Molecular Sciences Volume: 19 Issue: 4 Pages: 979-979
  • DOI: 10.3390/ijms19040979
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] GnRH agonist pre-treatment for microwave endometrial ablation in women with less than 1 centimetre myometrial thickness (2018)
  • Author(s): Nakamura Kohei、Nakayama Kentaro、Ishikawa Masako、Katagiri Atsuko、Katagiri Hiroshi、Ishibashi Tomoka、Sato Emi、Kyo Satoru
  • Journal Title: Journal of Obstetrics and Gynaecology Volume: 21 Issue: 8 Pages: 1-3
  • DOI: 10.1080/01443615.2018.1436163
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma (2018)
  • Author(s): Nakamura Kohei、Nakayama Kentaro、Minamoto Toshiko、Ishibashi Tomoka、Sanuki Kaori、Yamashita Hitomi、Ono Ruriko、Sasamori Hiroki、Komatsu?Fujii Takayoshi、Ishikawa Masako、Kyo Satoru
  • Journal Title: Molecular and Clinical Oncology Volume: 8 Pages: 429-433
  • DOI: 10.3892/mco.2018.1551
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Loss of beclin 1 expression in ovarian cancer: a potential biomarker to predict unfavorable outcome. (2018)
  • Author(s): Minamoto T, Nakayama K, Nakamura K, Katagiri H, Sultana R, Ishibashi T, Ishikawa M, Yamashita H, Sanuki K, Iida K, Nakayama S, Otsuki Y, Ishikawa N, Kyo S.
  • Journal Title: Oncol Lett Volume: 15 Pages: 1170-1176
  • DOI: 10.3892/ol.2017.7379
  • Peer Reviewed / Open Access
• [Journal Article] Reconstitution of high-grade serous ovarian carcinoma from primary fallopian tube secretory epithelial cells (2017)
  • Author(s): Nakamura Kohei、Nakayama Kentaro、Ishikawa Noriyoshi、Ishikawa Masako、Sultana Razia、Kiyono Tohru、Kyo Satoru
  • Journal Title: Oncotarget Volume: 9 Issue: 16 Pages: 12609-12619
  • DOI: 10.18632/oncotarget.23035
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Microsatellite instability is a potential biomarker for immune checkpoint inhibitors in endometrial cancer. (2017)
  • Author(s): Yamashita H, Nakayama K, Ishikawa M, Nakamura K, Ishibashi T, Sanuki K, Ono R, Sasamori H, Minamoto T, Iida K, Sultana R, Ishikawa N, Kyo S.
  • Journal Title: Oncotarget Volume: 9 Issue: 5 Pages: 5642-5654
  • DOI: 10.18632/oncotarget.23790
  • Peer Reviewed / Open Access
• [Journal Article] Long-term outcomes of microwave endometrial ablation for treatment of patients with menorrhagia: A retrospective cohort study (2017)
  • Author(s): Nakamura Kohei、Nakayama Kentaro、Sanuki Kaori、Minamoto Toshiko、Ishibashi Tomoka、Sato Emi、Yamashita Hitomi、Ishikawa Masako、Kyo Satoru
  • Journal Title: Oncology Letters Volume: 14 Pages: 7783-7790
  • DOI: 10.3892/ol.2017.7208
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Metastasis of breast cancer to an endometrial polyp, the cervix and a leiomyoma: A case report and review of the literature. (2017)
  • Author(s): Razia S, Nakayama K, Tsukao M, Nakamura K, Ishikawa M, Ishibashi T, Ishikawa N, Sanuki K, Yamashita H, Ono R, Hossain MM, Minamoto T, Kyo S.
  • Journal Title: Oncol Lett. Volume: Oct;14(4) Issue: 4 Pages: 4585-4592
  • DOI: 10.3892/ol.2017.6822
  • Peer Reviewed / Open Access
• [Journal Article] NAC1/Gadd45GIP1 axis is related to cisplatin resistance through cellular senescence in ovarian cancer. (2017)
  • Author(s): Nakayama K, Rahman M, Rahman MT, Nakamura K, Sato E, Katagiri H, Ishibashi T, Ishikawa M, Iida K, Razia S, Ishikawa N, Kyo S
  • Journal Title: Oncol Lett. Volume: 13(6) Issue: 6 Pages: 4713-4719
  • DOI: 10.3892/ol.2017.6099
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of metformin for advanced-stage endometrial cancer: A case report. (2017)
  • Author(s): Sato E, Nakayama K, Nakamura K, Ishikawa N, Ishikawa M, Minamoto T, Ishibashi T, Kyo S
  • Journal Title: Mol Clin Oncol. Volume: 6(3) Issue: 3 Pages: 441-443
  • DOI: 10.3892/mco.2017.1130
  • Peer Reviewed / Open Access
• [Journal Article] High-grade serous ovarian cancer 3 years after bilateral salpingectomy: A case report. (2017)
  • Author(s): Sato E, Nakayama K, Ishikawa M, Nakamura K, Ishibashi T, Kyo S
  • Journal Title: Mol Clin Oncol. Volume: 6(2) Issue: 2 Pages: 201-203
  • DOI: 10.3892/mco.2016.1105
  • Peer Reviewed / Open Access
• [Journal Article] The diagnostic utility of PAX8 immunostaining of malignant peritoneal mesothelioma presented as serous ovarian carcinomas: A single center experience of two cases. (2017)
  • Author(s): Nakamura K, Nakayama K, Nagaoka R, Nishisako K, Ishikawa M, Katagiri H, Sato E, Amano C, Kyo S.
  • Journal Title: Oncol Lett. Volume: 13 Issue: 1 Pages: 263-266
  • DOI: 10.3892/ol.2016.5444
  • Peer Reviewed / Open Access
• [Journal Article] Total laparoscopic hysterectomy for large cervical myoma of the uterus (2017)
  • Author(s): Nakayama K, Tsukao M, Ishikawa M, Ishibashi T, Nakamura K, Sanuki K, Yamashita H, Ono R, Minamoto T, Kyo S
  • Journal Title: MolClinOncol. Volume: 6(5) Pages: 655-660
  • Peer Reviewed / Open Access
• [Journal Article] Letrozole as second-line hormonal treatment for recurrent low-grade endometrial stromal sarcoma: A case report and review of the literature. (2016)
  • Author(s): Nakamura K, Nakayama K, Ishikawa M, Ishikawa N, Katagiri H, Katagiri A, Ishibashi T, Sato E, Iida K, Sultana R, Kyo S.
  • Journal Title: Oncol Lett. Volume: 12(5) Pages: 3856-3860
  • Peer Reviewed / Open Access
• [Journal Article] Case series of cerebral infarction with Trousseau's syndrome associated with malignant gynecological tumors. (2016)
  • Author(s): Ishikawa M, Nakayama K, Ishibashi T, Sato E, Nakamura K, Katagiri H, Kyo S
  • Journal Title: Mol Clin Oncol. Volume: 5(1) Pages: 138-142
  • Open Access
• [Journal Article] Utility of ovarian biopsy in pancreatic metastasis of high-grade serous ovarian carcinoma: A case report. (2016)
  • Author(s): Nakamura K, Nakayama K, Ishikawa M, Ishikawa N, Nagase M, Katagiri H, Ishibashi T, Sato E, Iida K, Sultana R, Kyo S
  • Journal Title: Mol Clin Oncol. Volume: 5(1) Pages: 41-43
  • Peer Reviewed / Open Access
• [Journal Article] High Pre-treatment Plasma D-Dimer Level as a Potential Prognostic Biomarker for Cervical Carcinoma. (2016)
  • Author(s): Nakamura K, Nakayama K, Ishikawa M, Katagiri H, Minamoto T, Ishibashi T, Ishikawa N, Sato E, Sanuki K, Yamashita H, Komatsu-Fujii T, Kyo S
  • Journal Title: Anticancer Res. Volume: 36(6) Pages: 2933-2938
  • Peer Reviewed / Open Access
• [Journal Article] KRAS/BRAF Analysis in Ovarian Low-Grade Serous Carcinoma Having Synchronous All Pathological Precursor Regions. (2016)
  • Author(s): Nakamura K, Nakayama K, Ishibashi T, Ishikawa N, Ishikawa M, Katagiri H, Minamoto T, Sato E, Sanuki K, Yamashita H, Iida K, Sultana R, Kyo S.
  • Journal Title: Int J Mol Sci. Volume: １７ Issue: 5 Pages: 625-625
  • DOI: 10.3390/ijms17050625
  • Peer Reviewed / Open Access
• [Journal Article] High pretreatment plasma D-dimer levels are related to shorter overall survival in endometrial carcinoma. (2016)
  • Author(s): Nakamura K, Nakayama K, Ishikawa M, Katagiri H, Minamoto T, Ishibashi T, Ishikawa N, Sato E, Sanuki K, Yamashita H, Komatsu-Fujii T, Kyo S.
  • Journal Title: Eur J Obstet Gynecol Reprod Biol. Volume: 201 Pages: 89-93
  • DOI: 10.1016/j.ejogrb.2016.03.041
  • Peer Reviewed / Open Access
• [Journal Article] CCNE1 amplification is associated with aggressive potential in endometrioid endometrial carcinomas. (2016)
  • Author(s): Nakayama K, Rahman MT, Rahman M, Nakamura K, Ishikawa M, Katagiri H, Sato E, Ishibashi T, Iida K, Ishikawa N, Kyo S.
  • Journal Title: Int J Oncol. Volume: 48 Pages: 506-16
  • Peer Reviewed / Open Access
• [Journal Article] Non-Hodgkin lymphoma of the female genital tract mimicking primary gynecological tumors: a single-center series of 3 cases. (2016)
  • Author(s): Rahman M, Nakayama K, Rahman MT, Ishikawa M, Katagiri H, Katagiri A, Sato E, Iida K, Miyazaki K.
  • Journal Title: Eur J Gynaecol Oncol Volume: 37 Pages: 117-21
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of microwave ablation for the treatment of endometrial carcinoma: A report of 3 cases. (2016)
  • Author(s): Nakamura K, Nakayama K, Ishikawa M, Katagiri H, Ishibashi T, Sato E, Amano C, Kyo S.
  • Journal Title: Oncol Lett. Volume: 11 Pages: 3025-27
  • Peer Reviewed / Open Access
• [Journal Article] Nerve-sparing abdominal radical trachelectomy: a novel concept to preserve uterine branches of pelvic nerves. (2015)
  • Author(s): Kyo S, Mizumoto Y, Takakura M, Nakamura M, Sato E, Katagiri H, Ishikawa M, Nakayama K, Fujiwara H.
  • Journal Title: Eur J Obstet Gynecol Reprod Biol. Volume: 193 Pages: 5-9
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of multiple microwave endometrial ablation technique for menorrhagia resulting from adenomyosis. (2015)
  • Author(s): Nakamura K, Nakayama K, Ishikawa M, Katagiri H, Katagiri A, Ishibashi T, Sato E, Asakawa Y, Kyo S.
  • Journal Title: J Obstet Gynaecol Res. Volume: 41 Pages: 1769-72
  • Peer Reviewed / Open Access
• [Journal Article] Loss of autophagy-related protein Beclin 1 may define poor prognosis in ovarian clear cell carcinomas. (2015)
  • Author(s): Katagiri H, Nakayama K, Razia S, Nakamura K, Sato E, Ishibashi T, Ishikawa M, Iida K, Ishikawa N, Otsuki Y, Nakayama S, Kyo S.
  • Journal Title: Int J Oncol. Volume: 47 Pages: 2037-44
  • Peer Reviewed / Open Access
• [Presentation] 卵巣癌・子宮内膜癌 同時発症症例における遺伝子変異の検討 (2017)
  • Author(s): 石川雅子、中山健太郎、小野瑠璃子、佐貫薫、山下瞳、中村康平、石橋朋佳、皆本敏子、スルタナラジア、飯田幸司、京 哲
  • Organizer: 日本産科婦人科学会
• [Presentation] Liquid microdissection で抽出したDNAを用いた卵巣類内膜癌・明細胞癌の発癌機構についての検討 (2016)
  • Author(s): 石川雅子、中山健太郎、小野瑠璃子、山下瞳、佐貫薫、中村康平、石橋朋佳、皆本敏子、京哲
  • Organizer: 第58回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 米子
  • Year and Date: 2016-07-08
• [Presentation] 初代培養、cell sorting systemで抽出したDNAを用いた子宮内膜症関連卵巣癌の遺伝子解析 (2016)
  • Author(s): 石川雅子、中山健太郎、野瑠璃子、山下瞳、佐貫薫、中村康平、原友美、石橋朋佳、折出亜希、皆本敏子、金崎春彦、京哲
  • Organizer: 第68回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-04-22
• [Presentation] 卵巣明細胞癌と卵巣類内膜癌の発癌機構についての検討 (2016)
  • Author(s): 石川雅子、中山健太郎 、佐貫薫、山下瞳、佐藤絵美、中村康平、石橋朋佳、片桐浩、片桐敦子 、飯田幸司 、 Razia Sultana、皆本敏子、京 哲
  • Organizer: 第37回日本エンドメトリオーシス学会学術講演会
  • Place of Presentation: ホテル日航熊本
  • Year and Date: 2016-01-23
• [Presentation] 両側卵管切除後３年でHigh-grade 漿液性腺癌を発症した1例 (2015)
  • Author(s): 石川雅子、中山健太郎、佐藤絵美、中村康平、片桐浩、片桐敦子、飯田幸司、折出亜希、金崎春彦、京 哲
  • Organizer: 第57回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-09