Estrogen-related receptor alpha as a potential target for endometrial cancer
| Project/Area Number |
15K10726
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Mori Taisuke 京都府立医科大学, 医学(系)研究科(研究院), 講師 (00569824)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 子宮体癌 / ホルモン依存性腫瘍 / エストロゲン受容体 / ホルモン療法 |
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| Outline of Final Research Achievements |
The elevated levels of ERRa was associated with advanced clinical stages and serous histological type. ERRa demonstrated negative prognostic significance. Knockdown of ERRa suppressed angiogenesis via VEGF, inhibited cell proliferation and induced cell cycle arrest at the mitotic phase and caspase-3 dependent apoptosis. A significant reduction of tumor growth and angiogenesis was observed in xenografts with ERRa knockdown. We propose that ERRa can serve as a novel target for molecular therapy of endometrial cancer.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Phase II study of adjuvant chemotherapy with paclitaxel and nedaplatin for uterine cervical cancer with lymph node metastasis.2018
Author(s)
Takekuma M, Shimokawa M, Nishio S, Omi H, Tabata T, Takei Y, Nasu K, Takahashi Y, Toyota S, Ichikawa Y, Arakawa A, Ito F, Tsubamoto H, Mori T, Hirashima Y, Ito K.
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Journal Title
Cancer Sci
Volume: 25
Issue: 5
Pages: 1602-1608
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Current status of tertiary debulking surgery and prognosis after secondary debulking surgery for recurrent mullerian epithelial cancer in Japan: a retrospective analysis of 164 patients (KCOG-G1402).2017
Author(s)
Hirakawa T, Minaguchi T, Itani Y, Kasamatsu Y, Murase S, Sakurada S, Nagano H, Takehara K, Tsuruta T, Arakawa A, Kawano K, Tsubamoto H, Ushiwaka T, Mori T, Iwai K, Saito M, Morisawa H, Saito F, Yoshida K, Kaneuchi M, Sato H, Ito K, Nasu K.
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Journal Title
World J Surg Oncol.
Volume: 15
Pages: 132-132
Related Report
Peer Reviewed / Open Access
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[Journal Article] Abnormal lipid/lipoprotein metabolism and high plasma testosterone levels in male but not female aromatase-knockout mice2017
Author(s)
Amano A, Kondo Y, Noda Y, Ohta M, Kawanishi N, Machida S, Mitsuhashi K, Senmaru T, Fukui M, Takaoka O, Mori T, Kitawaki J, Ono M, Saibara T, Obayashi H, Ishigami A.
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Journal Title
Arch Biochem Biophys
Volume: -
Pages: 47-58
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Two chalcones, 4-hydroxyderricin and xanthoangelol, stimulate GLUT4-dependent glucose uptake through the LKB1/AMP-activated protein kinase signaling pathway in 3T3-L1 adipocytes2015
Author(s)
Ohta, Mitsuhiro; Fujinami, Aya; Kobayashi, Norihiro; Amano, Akiko; Ishigami, Akihito; Tokuda, Harukuni; Suzuki, Nobutaka; Ito, Fumitake; Mori, Taisuke; Sawada, Morio;
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Journal Title
Nutrition Research
Volume: 35(7)
Issue: 7
Pages: 618-625
DOI
Related Report
Peer Reviewed
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