New strategy for the treatment of adenomyosis and endometriosis via angiotensin receptors
Project/Area Number |
15K10734
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Nihon University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
山本 樹生 日本大学, 医学部, 客員教授 (40167721)
椙田 賢司 日本大学, 医学部, 兼任講師 (30386031)
林 忠佑 日本大学, 医学部, 助教 (70625417)
市川 剛 日本大学, 医学部, 兼任講師 (80599994)
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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Keywords | 子宮腺筋症 / 子宮内膜症 / AT1 / AT2 / MAS1 / AT1R / angiotensin-(1-7) / リモデリング / アンギオテンシン / mPGES-1 / PTGS-2 / Angiotensin II receptors / プロスタグランディン / Angiotensin II receptor / qPCR / immunohistochemistry / 定量的 PCR / 免疫組織化学 |
Outline of Final Research Achievements |
The AT1/AT2 ratio in endometriotic cysts was significantly increased compared with that in the eutopic endometrium in the proliferativephase in controls. There was a relationship between the AT1 mRNA expression and that of mPGES-1 mRNA in the endometriotic cysts. There was a significant relationship between the mRNA expression of the AT2 receptor and that of mPGES-1 in eutopic endometrium of non-endometriotic control. The MAS1 mRNA levels in ovarian endometriotic tissue were increased significantly regardless of the menstrual cycle phase. The MAS1 mRNA levels were significantly higher in the proliferative-tissues of the endometriosis patients than in those of the controls. The ratio of the MAS1 to the AT1 mRNA in the proliferative-tissues was increased predominantly in the endometriosis patients compared with that in the controls. Renin-angiotensinsystem may play an important role in the pathophysiology of endometriosis.
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Academic Significance and Societal Importance of the Research Achievements |
子宮腺筋症、子宮内膜症は、月経困難症や過多月経を呈し罹患女性のライフスタイルに大きな障害を及ぼす。薬物療法としては、子宮腺筋症の出血、疼痛などの症状に対し、プロスタグランディン(PG)合成酵素阻害剤のほか、GnRH agonist, proestogens, progsterone含有IU D、Low dose estrogen-progesterone(LEP)製剤などが用いられているが、満足のいく治療法は確立されていない。アンジオテンシンレセプターが、子宮内膜症や子宮腺筋症の増殖にする関与が示唆され、アンジオテンシンレセプターをターゲットとした新たな治療法の開発の糸口となる。
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Report
(5 results)
Research Products
(18 results)
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[Presentation] Dominant expression of angiotensin 1-7 receptor(MAS1)in the eutopic endometrium in the endometriosis patients2018
Author(s)
Takahiro Nakajima, Fumihisa Chishima, Takehiro Nakao, Chuyu Hayashi, Akiko Kasuga, Kaori Shinya, Takuo Nakayama, Hiromitsu Azuma, Go Ichikawa, Atsushi Komatsu, Tatsuo Yamamoto, Kei Kawana
Organizer
第70回日本産科婦人科学会学術講演会
Related Report
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[Presentation] Alteration of coagulation status in the patients with endometriotic cysts2018
Author(s)
Kanoko Shoji, Fumihisa Chishima, Takahiro Nakajima, Takehiro Nakao, Erina Kato, Hiromitsu Azuma, Chuyu Hayashi, Go Ichikawa, Atsushi Komatsu, Yasuji Miyakawa, Shinichi Takada, Kei Kawana
Organizer
第70回日本産科婦人科学会学術講演会
Related Report
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[Presentation] Exprssion of angiotrnsin1-7 receptor (MAS1), angiotensin (AT)1, AT2 receptors in endometriotic lesins.2017
Author(s)
Takahiro Nakajima, Fumihisa Chishima,, Nanoko Shoji, Takehiro Nakao, Erina Mato, Hiromitsu Azuma, Chuyu Hayashi, Go Ichikawa, Kenji Sugita, Shinici Takada, Tatsuo Yamamoto. Kei Kawana.
Organizer
37th Annual meeting, American Society for Reproductive Immunology
Related Report
Int'l Joint Research
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[Presentation] Tissue remodeling by renin-angiotensin system is uncontrolled in the endometriotic lesion and eutopic endometrium of endometriosis cases:2017
Author(s)
Takahiro Nakajima, Fumihisa Chishima, Takehiro Nakao, Erian Kato, Hiromitsu Azuma, Chuyu Hayashi, Go Ichikawa, Kenji Sugita, Shinichi Takada, Tatsuo Yamamoto, Kei Kawana:
Organizer
第69回日本産科婦人科学会学術講演会
Related Report
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[Presentation] Expression of prorenin(REN) and andiotensin 1-7 receptor (MAS1) mRNA and inlocal lesion of endometriosis lesions.2016
Author(s)
Takahiro Nakajima, Fumihisa Chishima, Takehiro Nakao, Chuyu Hayashi, Youichi Aoki, Motomi Yamazaki, Go Ichikawa, Kenji Sugita, Tatsuo Yamamoto
Organizer
13th Congress of the International Society for Immunology of Reproduction, Erfurt, Germany
Place of Presentation
Erfurt, Germany
Year and Date
2016-06-23
Related Report
Int'l Joint Research
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[Presentation] The ratio of AT1/AT2 receptors mRNA expression in local lesions of endometriosis2015
Author(s)
Takehiro Nakao, Fumihisa Chishima, Takahiro Nakajima, Masahiko Sugitani, Chuyu Hayashi, Manami Suzuki,Go Ichikawa, Kenji Sugita, Tatsuo Yamamoto
Organizer
35thAnnual meeting, American Society for Reproductive Immunology
Place of Presentation
Kingstone, Ontario, Canada
Year and Date
2015-06-04
Related Report
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