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Identification of endometrial adenocarcinoma biomarkers and therapeutic target candidates by proteomic analysis

Research Project

Project/Area Number 15K10735
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNippon Medical School

Principal Investigator

Peng Wei-Xia  日本医科大学, 医学部, 講師 (00535700)

Co-Investigator(Kenkyū-buntansha) 内藤 善哉  日本医科大学, 大学院医学研究科, 大学院教授 (20237184)
和田 龍一  日本医科大学, 医学部, 准教授 (20260408)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords子宮内膜癌 / 予後 / プロテオーム解析 / 免疫組織化学 / 類内膜癌 / 網羅的な蛋白質解析 / 脱分化 / 類内膜腺癌 / バイオマーカー
Outline of Final Research Achievements

To identify potential prognostic biomarkers in endometrioid carcinoma (EC), we performed proteomic analysis and immunohistochemistry (IHC). Firstly, we revealed the total protein expression in 3 grades ECs respectively, and compared the protein expression profiles between grades. Then we validated the protein expression using IHC and compared the protein expression patterns with clinical factors. Compare to G1 EC, differentially expressed proteins in G3 was 56 types. Among them, we focused the Filamin A. In IHC study, G3 ECs showed significantly higher expression of Filamin A than G1 and G2 ECs. Furthermore, strong expression of Filamin A tended to be associated with cancer frequent recurrence and lymphovascular invasion.The current analysis revealed the significant association of high expression Filamin A and unfavorable prognostic factors of ECs, suggesting that Filamin A may play a critical role in EC invasiveness and prognosis.

Academic Significance and Societal Importance of the Research Achievements

今回の検討では、Filamin Aの発現は子宮類内膜癌の脱分化に関与する可能性が示唆され、予後不良のバイオマーカーとして有用の可能性が考えられる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2019 2018 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Downregulation of protein disulfide-isomerase A3 expression inhibits cell proliferation and induces apoptosis through STAT3 signaling in hepatocellular carcinoma2019

    • Author(s)
      Kondo R, Ishino K, Wada R, Takata H, Peng WX, Kudo M, Kure S, Kaneya Y, Taniai N, Yoshida H, Naito Z
    • Journal Title

      International Journal of Oncology

      Volume: 54 Pages: 1409-1421

    • DOI

      10.3892/ijo.2019.4710

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2-Deoxy-D-glucose increases GFAT1 phosphorylation resulting in endoplasmic reticulum-related apoptosis via disruption of protein N-glycosylation in pancreatic cancer cells2018

    • Author(s)
      Ishino K, Kudo M, Peng WX, Kure S, Kawahara K, Teduka K, Kawamoto Y, Kitamura T, Fujii T, Yamamoto T, Wada R, Naito Z
    • Journal Title

      Biochem Biophys Res Comm

      Volume: 501 Issue: 3 Pages: 668-673

    • DOI

      10.1016/j.bbrc.2018.05.041

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 平滑筋分化を伴った低悪性度子宮内膜間質肉腫の1例2017

    • Author(s)
      呉 壮香, 和田 龍一, 彭 為霞, 坂谷 貴司, 内藤 善哉
    • Journal Title

      診断病理

      Volume: 34 Pages: 1345-6431

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of aldolase A as a potential diagnostic biomarker for colorectal cancer based on proteomic analysis using formalin-fixed paraffin-embedded tissue.2016

    • Author(s)
      Yamamoto T, Kudo M, Peng WX, Takata H, Takakura H, Teduka K, Fujii T, Mitamura K, Taga A, Uchida E, Naito Z.
    • Journal Title

      Tumour Biol

      Volume: 37 Pages: 13595-13606

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased expression of PDIA3 and its association with cancer cell proliferation and poor prognosis in hepatocellular carcinoma.2016

    • Author(s)
      Takata H, Kudo M, Yamamoto T, Ueda J, Ishino K, Peng WX, Wada R, Taniai N, Yoshida H, Uchida E, Naito Z.
    • Journal Title

      Oncol Lett.

      Volume: 12 Issue: 1 Pages: 4896-4904

    • DOI

      10.1097/prs.0000000000002900

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insulin-like growth factor 2 mRNA-binding protein-3 as a marker for distinguishing between cutaneous squamous cell carcinoma and keratoacanthoma.2016

    • Author(s)
      Kanzaki A, Kudo M, Ansai S, Peng WX, Ishino K, Yamamoto T, Wada R, Fujii T, Teduka K, Kawahara K, Kawamoto Y, Kitamura T, Kawana S, Saeki H, Naito Z.
    • Journal Title

      Int J Oncol

      Volume: 48 Issue: 3 Pages: 1007-15

    • DOI

      10.3892/ijo.2016.3323

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 子宮内膜細胞診で発見された原発性卵管癌の1例2017

    • Author(s)
      Wei-Xia Peng
    • Organizer
      第58回日本臨床細胞学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] A soft tissue tumor with extensive myxoid change in femal genital tract2016

    • Author(s)
      Wei-Xia Peng
    • Organizer
      The 20th Japan Taiwan Korea Joint Meeting for Gynecological Pathology
    • Place of Presentation
      韓国・ソウル大学
    • Year and Date
      2016-09-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Malignant endometrial polyp: a case report2015

    • Author(s)
      Wei-Xia Peng, Kousuke Ishino, Keisuke Kurose, Mitsuhiro Kudo, Ryuichi Wada, Zenya Naito
    • Organizer
      The 39th European Congress of Cytology
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2015-09-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] カラーイラストで学ぶ 集中講義 病理学2016

    • Author(s)
      彭 為霞 (共著)
    • Total Pages
      354
    • Publisher
      メジカルビュー社
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2023-03-23  

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