| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
ANCA(Antineutrophil cytoplasmic antibody) associated vasculitis is defined as a minor arterial vasculitis caused by the ANCA. Most of the intractable otitis media had not been explained by the known etiology may be this ANCA associated vasculits(OMAAV). This research, aimed to clarify the mechanism of inner ear damage of OMAAV by using the model mice. Propylthiouracil (PTU)is an antithyroid drug for the treatment of hyperthyroidism, and about 30% of the patients received PTU produce MPO positive ANCA associated vasculitis(AAV). The histological findings of MPO-ANCA positive AAV model mice induced by PTU did not show the remarkable vasculitis in the inner ear.
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