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Mucosal regenerative medicine for middle ear by using cell sheet technology

Research Project

Project/Area Number 15K10766
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionJikei University School of Medicine

Principal Investigator

Hiromi Kojima  東京慈恵会医科大学, 医学部, 教授 (60234762)

Co-Investigator(Kenkyū-buntansha) 和田 弘太  東邦大学, 医学部, 教授 (20307482)
山本 和央  東京慈恵会医科大学, 医学部, 助教 (50408449)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords中耳粘膜 / 粘膜再生 / 細胞シート / 中耳真珠腫 / 癒着性中耳炎 / 温度応答性培養皿 / 再生医療 / 鼻腔粘膜 / 真珠腫 / 鼻粘膜 / 鼓室形成術
Outline of Final Research Achievements

The recurrence of cholesteatoma and re-adhesion of the tympanic membrane are often occurred after conventional tympanoplasty. Although regenerated middle ear mucosa plays a key role in prevention of recurrence, much of mucosa is lost in the process of the tympanoplasty. To overcome this problem, we considered that the middle ear mucosa can be regenerated rapidly, the results of treatment can potentially be improved.
After basic research, we developed a novel regenerative medicine combining tympanoplasty and autologous nasal mucosal epithelial cell sheet transplantation for regeneration of the middle ear. We performed this procedure on seven patients with middle ear cholesteatoma and three patients with adhesive otitis media in this study. All patients showed favorable postoperative course with no adverse events or complications and the patients’ hearing ability post-transplantation remained good.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (13 results) (of which Int'l Joint Research: 5 results,  Invited: 10 results)

  • [Journal Article] Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation.2017

    • Author(s)
      Yamamoto K, Yamato M, Morino T, Sugiyama H, Takagi R, Yaguchi Y, Okano T, Kojima H
    • Journal Title

      npj Regenerative Medicine

      Volume: 2 Issue: 1 Pages: 1-11

    • DOI

      10.1038/s41536-017-0010-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autologous human nasal epithelial cell sheet using temperature-responsive culture insert for transplantation after middle ear surgery.2015

    • Author(s)
      66) Hama T, Yamamoto K, Yaguchi Y, Murakami D, Sasaki H, Yamato M, Okano T, Kojima H.
    • Journal Title

      J Tissue Eng Regen Med.

      Volume: 1 Issue: 4 Pages: 1-10

    • DOI

      10.1002/term.2012

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] モーニングセミナー「耳小骨形成」2017

    • Author(s)
      小島博己
    • Organizer
      第118回日本耳鼻咽喉科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] パネルディスカッション「慈恵医大が求める医師・学生像―プロフェッショナリズム育成に関わる今後の課題 ①現在の問題点と今後の課題」2017

    • Author(s)
      小島博己
    • Organizer
      第134回成医会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] New Technology:Cell Sheet Transplantation by TEES2017

    • Author(s)
      Hiromi Kojima
    • Organizer
      6thEast Asian Symposium on Otology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Realization of middle ear mucosal regeneration by cultured nasal mucosal epithelial cell sheet transplantation2017

    • Author(s)
      Hiromi Kojima
    • Organizer
      JSRM-ACTO Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 鼓室形成術のコツ2017

    • Author(s)
      小島博己
    • Organizer
      日本耳鼻咽喉科学会 第31回専門医講習会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 中耳真珠腫の治療戦略ー従来の手術の限界と再生医療による新規治療の試みー2017

    • Author(s)
      小島博己
    • Organizer
      NAGOYA ENTセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 「中耳真珠腫の治療戦略」~従来の手術の限界と再生医療による新規治療の試み~.(耳鼻咽喉科専門医領域講習)2017

    • Author(s)
      小島博己
    • Organizer
      第2回青葉・愛宕耳鼻咽喉科研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 鼻粘膜上皮細胞シート移植による中耳粘膜再生2016

    • Author(s)
      小島博己
    • Organizer
      第26回日本耳科学会
    • Place of Presentation
      長野
    • Year and Date
      2016-10-08
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Moving forward toward the clinical use of cell-sheet regenerative medicine. (Corporate Seminar)2016

    • Author(s)
      Hiromi Kojima
    • Organizer
      The 22nd Annual Meeting of Japan Society of Gene and Cell Therapy.
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-07-29
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] The new technology: Canal up tympanoplasty with transplantation of tissue-engineered cell sheets.2016

    • Author(s)
      Hiromi Kojima
    • Organizer
      5th East Asian Symposium on Otology & 2nd Asian Otology Meeting
    • Place of Presentation
      Sha Tin, Hong Kong
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 難治性中耳疾患に対する再生医療 (ヒト鼻腔粘膜上皮細胞シート移植を併用した鼓室形成術)2016

    • Author(s)
      小島博己
    • Organizer
      日本再生医療学会
    • Place of Presentation
      大阪
    • Year and Date
      2016-03-16
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] The new technology: canal wall up tympanoplasty with transplantation of tissue-engineered cell sheets2015

    • Author(s)
      Hiromi Kojima
    • Organizer
      Japan-Taiwan conference
    • Place of Presentation
      東京
    • Year and Date
      2015-12-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The new technology: canal wall up tympanoplasty with transplantation of tissue-engineered cell sheets2015

    • Author(s)
      Hiromi Kojima
    • Organizer
      Politzer Society
    • Place of Presentation
      Niigata, Japan
    • Year and Date
      2015-07-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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