Basic research to investigate the mechanism of vestibuar migraine
| Project/Area Number |
15K10772
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) |
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Principal Investigator |
Goto Fumiyuki 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 医師 (80286567)
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| Co-Investigator(Kenkyū-buntansha) |
北原 糺 奈良県立医科大学, 医学部, 教授 (30343255)
鳥海 春樹 慶應義塾大学, 医学部(信濃町), 講師(非常勤) (30528203)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 片頭痛 / 細胞死 / 疼痛刺激 / TRPA1 / エクソソーム / TLR7 / microRNA let-7b / めまい |
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| Outline of Final Research Achievements |
MiRNA let-7b play a major role to regulate cell death through the interaction with Toll-like Receptor 7 (TLR7). The number of apoptotic cells were significantly increased in let-7b-exposed cells. The expression of TLR7 was increased in let-7b-exposed cells. However, the number of apoptotic cells remained unchanged in let-7b-exposed TLR7 knock down cells. The number of apoptotic cells remained unchanged in let-7b inhibitor-treated cells after exposed to TLR7 agonist. The expression of creaved-caspase-3 and LC3-II was significantly increased in TLR7 agonist -exposed cells, while let-7b inhibitor regulated apoptosis mediated by TLR7 agonist. Our results indicated that miRNA let-7b/TLR7 signaling interaction could be a new therapeutic target for auditory cell death.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness: An exploratory study.2017
Author(s)
Koganemaru S, Goto F, Arai M, Toshikuni K, Hosoya M, Wakabayashi T, Yamamoto N, Minami S, Ikeda S, Ikoma K, Mima T.
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Journal Title
Brain Stimulation
Volume: -
Issue: 3
Pages: 576-578
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] tcDCS(経頭蓋小脳直流電気刺激)を用い前庭リハビリテーションの効果増強を試みた2症例2017
Author(s)
五島 史行, 荒井 美希, 利國 桂太郎, 若林 毅, 細谷 誠, 山本 修子, 南 修司郎, 松永 達雄, 角田 晃一, 美馬 達哉, 小金丸 聡子
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Journal Title
耳鼻咽喉科・頭頸部外科
Volume: 89
Pages: 471-475
Related Report
Peer Reviewed
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