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Basic research to investigate the mechanism of vestibuar migraine

Research Project

Project/Area Number 15K10772
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research Institution独立行政法人国立病院機構(東京医療センター臨床研究センター)

Principal Investigator

Goto Fumiyuki  独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 医師 (80286567)

Co-Investigator(Kenkyū-buntansha) 北原 糺  奈良県立医科大学, 医学部, 教授 (30343255)
鳥海 春樹  慶應義塾大学, 医学部(信濃町), 講師(非常勤) (30528203)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords片頭痛 / 細胞死 / 疼痛刺激 / TRPA1 / エクソソーム / TLR7 / microRNA let-7b / めまい
Outline of Final Research Achievements

MiRNA let-7b play a major role to regulate cell death through the interaction with Toll-like Receptor 7 (TLR7). The number of apoptotic cells were significantly increased in let-7b-exposed cells. The expression of TLR7 was increased in let-7b-exposed cells. However, the number of apoptotic cells remained unchanged in let-7b-exposed TLR7 knock down cells. The number of apoptotic cells remained unchanged in let-7b inhibitor-treated cells after exposed to TLR7 agonist. The expression of creaved-caspase-3 and LC3-II was significantly increased in TLR7 agonist -exposed cells, while let-7b inhibitor regulated apoptosis mediated by TLR7 agonist. Our results indicated that miRNA let-7b/TLR7 signaling interaction could be a new therapeutic target for auditory cell death.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (23 results)

All 2018 2017 2016 2015

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (11 results) (of which Int'l Joint Research: 4 results) Book (1 results)

  • [Journal Article] Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness: An exploratory study.2017

    • Author(s)
      Koganemaru S, Goto F, Arai M, Toshikuni K, Hosoya M, Wakabayashi T, Yamamoto N, Minami S, Ikeda S, Ikoma K, Mima T.
    • Journal Title

      Brain Stimulation

      Volume: - Issue: 3 Pages: 576-578

    • DOI

      10.1016/j.brs.2017.02.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Is the Headache in Patients with Vestibular Migraine Attenuated by Vestibular Rehabilitation?2017

    • Author(s)
      Sugaya Nagisa、Arai Miki、Goto Fumiyuki
    • Journal Title

      Frontiers in Neurology

      Volume: 8 Pages: 124-124

    • DOI

      10.3389/fneur.2017.00124

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] tcDCS(経頭蓋小脳直流電気刺激)を用い前庭リハビリテーションの効果増強を試みた2症例2017

    • Author(s)
      五島 史行, 荒井 美希, 利國 桂太郎, 若林 毅, 細谷 誠, 山本 修子, 南 修司郎, 松永 達雄, 角田 晃一, 美馬 達哉, 小金丸 聡子
    • Journal Title

      耳鼻咽喉科・頭頸部外科

      Volume: 89 Pages: 471-475

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 前庭性と心原性の鑑別を要したドロップアタックの3症例2017

    • Author(s)
      小板橋 美香, 荒井 美希, 五島 史行
    • Journal Title

      耳鼻咽喉科・頭頸部外科

      Volume: 89 Pages: 843-847

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 前庭型片頭痛患者の前庭動眼反射機能についてvideo head impulse test(vHIT)を用いた検討2017

    • Author(s)
      小板橋 美香, 五島 史行, 荒井 美希, 新藤 晋, 池園 哲郎
    • Journal Title

      耳鼻咽喉科・頭頸部外科

      Volume: 89 Pages: 367-372

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of sleep disturbance in patients with chronic dizziness2017

    • Author(s)
      Sugaya N,Arai M ,Goto F
    • Journal Title

      Acta Otolaryngol.

      Volume: Jan;137(1) Pages: 47-52

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of a meningeal carcinomatosis of the internal auditory meatus treated as sudden deafness2016

    • Author(s)
      Goto F, Arai M, Wakabayashi T , Otomo T, Nagai R, Minami S ,Shimada T, Fujii M
    • Journal Title

      Research in Vestibular Science

      Volume: 14(4) Pages: 139-142

    • Related Report
      2016 Research-status Report
  • [Journal Article] A Case of Undiagnosed Sleep Disorder with Hearing Difficulty and Dizziness2016

    • Author(s)
      Goto F, Arai M, Kitamura M, Otomo T, Nagai R, Minami S, Shimada T, Matsunaga T, Tsunoda K, Fujii M
    • Journal Title

      Iran J Otorhinolaryngol

      Volume: 28(85) Pages: 149-52

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship of physical distress to dizziness in patients with fibromyalgia.2016

    • Author(s)
      Sawada F, Nomura Y, Goto F, Murakami M, Jike M, Toi T, Furusaka T, Ikeda M, Oshima T
    • Journal Title

      Acta Otolaryngol

      Volume: 136 Pages: 56-61

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A case of undiagnosed sleep disorder complaining hearing difficulty and dizziness.2015

    • Author(s)
      Goto F, Arai M, Kitamura M , Otomo A, Nagai R, Shimada T, Minami S,Matsunaga T, Tsuoda K, Fujii M.
    • Journal Title

      The Iranian Journal of Otolaryngology

      Volume: 2 Pages: 100-100

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] The influence of headaches in patients with chronic dizziness2015

    • Author(s)
      Goto F, Arai M, Arai M,
    • Journal Title

      Acta Otolaryngol

      Volume: 27 Pages: 1-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] TLR7とTRPA1を介した細胞外microRNA let-7bの内耳感覚細胞死と細胞興奮メカニズム2018

    • Author(s)
      林 賢、五島史行、野村泰之、岸野明洋、神崎晶,小川郁
    • Organizer
      第118回日本耳鼻咽喉科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 内耳感覚細胞におけるエクソソーム内microRNA let-7bの新規分子標的としての有用性2018

    • Author(s)
      林 賢、五島史行、野村泰之、岸野明洋、神崎晶、小川郁
    • Organizer
      第27回日本耳科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The new insights into cell death and cellular hyper-excitability in auditory-brain2018

    • Author(s)
      Ken Hayashi, Fumiyuki Goto, Akihiro Kishino, Yasuyuki Nomura, Hirokazu Takahashi, Sho Kanzaki, Kaoru Ogawa
    • Organizer
      17th Korea-Japan joint meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] microRNA let-7b activates Toll-like receptor 7 and causes cell death in auditory cell2016

    • Author(s)
      Ken Hayashi, Fumiyuki Goto, Yasuyuki Nomura, Akio Kishino, Kaoru Ogawa
    • Organizer
      AAO-HNSF
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-09-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 難治性めまいにしめる精神神経疾患2016

    • Author(s)
      五島史行、荒井美希、若林毅、佐山章子、永井遼斗、南修司郎、島田貴信、藤井正人
    • Organizer
      日本耳鼻咽喉科学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2016-05-20
    • Related Report
      2016 Research-status Report
  • [Presentation] The function analysis of microRNA let-7b packed into exosome in auditory cell2016

    • Author(s)
      Ken Hayashi, Fumiyuki Goto, Yasuyuki Nomura, Akio Kishino , Kaoru Ogawa
    • Organizer
      16th Korea-Japan joint meeting
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 頭痛は難治性めまい患者の苦痛度に影響を与えるか?2016

    • Author(s)
      五島史行
    • Organizer
      第44回日本頭痛学会
    • Place of Presentation
      京都ウエスティンホテル
    • Related Report
      2016 Research-status Report
  • [Presentation] 片頭痛関連めまいとその他の難治性めまい患者の治療によるめまいおよび頭痛苦痛度の変化2016

    • Author(s)
      五島史行
    • Organizer
      日本耳科学会
    • Place of Presentation
      松本市
    • Related Report
      2016 Research-status Report
  • [Presentation] 頭痛は難治性めまい患者の苦痛度に影響を与えるか?2016

    • Author(s)
      五島史行
    • Organizer
      日本頭痛学会
    • Place of Presentation
      京都
    • Related Report
      2016 Research-status Report
  • [Presentation] tDCSによる前庭リハビリテーションの効果増強のこころみ2016

    • Author(s)
      五島史行,小金丸聡子
    • Organizer
      第75回日本めまい平衡医学会
    • Place of Presentation
      大阪
    • Related Report
      2016 Research-status Report
  • [Presentation] The influence of headaches in patients with chronic dizziness2016

    • Author(s)
      GotoF,Arai M, Arai M
    • Organizer
      29th Barany Society meeting
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] 薬に頼らずめまいを治す方法2017

    • Author(s)
      五島史行
    • Total Pages
      200
    • Publisher
      アチーブメント出版
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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