basic research of SIRT1 activator for curative treatment of allergic rhinitis
Project/Area Number |
15K10775
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
|
Research Institution | Hokkaido University |
Principal Investigator |
Nakamaru Yuji 北海道大学, 医学研究院, 准教授 (20344509)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | アレルギー学 / ヒストンアセチル化酵素 / アレルギー性鼻炎 / TSLP |
Outline of Final Research Achievements |
To elucidate histone deacetylase for production of TSLP in patients with allergic rhinitis we used Beas-2B cells. After those cells were confluent, the inhibitor of histone deacetylase was added. Thirty minutes after the inhibitor was added, we stimulated the cells with ODN2006. Twenty four hours later, those cells were collected and the amout of TSLP mRNA was evaluated. We found that the inhibitor of histone deacetylase increased the amount of TSLP with dose-dependent manner. On the other hand,the activator of histone deacetylase decleased the amount of TSLP with dose-dependent manner.
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Report
(4 results)
Research Products
(1 results)