Development of new treatments for chronic rhinosinusitis

• Project/Area Number: 15K10777
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Yamagata University
• Principal Investigator: Ishida Akihiro 山形大学, 医学部, 非常勤講師 (00361246)
• Co-Investigator(Kenkyū-buntansha): 鈴木 祐輔 山形大学, 医学部, 助教 (50466629) ; 千葉 真人 山形大学, 医学部, 非常勤講師 (80594324)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ペリオスチン / 慢性副鼻腔炎 / 鼻ポリープ / 好酸球性副鼻腔炎 / ポリープ / 線維化

Outline of Final Research Achievements

Several factors contribute to pathologies such as excessive mucus production and mucosal edema, leading to nasal discharge and obstruction in inflammatory nasal disorders. To assess the correlation between expression level of periostin and allergic inflammation, we investigated nasal polyps of eosinophilic chronic rhinosinusitis patients by immunohistochemistry. It was revealed that periostin expressed in subepithelial stroma layer of nasal polyp regardless of allergic inflammation or not.