| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In the olfactory epithelium, olfactory cells (OCs) and supporting cells (SCs) are arranged in a characteristic mosaic pattern, where OCs are separated each other and surrounded by SCs. The cellular pattern is established by cellular rearrangement during development. However, the mechanisms underlying this cellular rearrangement was unclear. In the olfactory epithelium, OCs express nectin-2 and N-cadherin, and SCs express nectin-2, necitn-3 and E-cadherin. Heterophilic trans-interaction between nectin-2 on OCs and nectin-3 on SCs recruits N-cadherin via alpha-catenin to the heterotypic junctions, and differential distribution of cadherins between junctions promote cellular intercalations, resulting in the formation of the mosaic pattern. These results suggest the possibility that synergistic action of nectins and cadhrins contributes to various complex cellular patterning, which cannot be achieved by a single mechanism.
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