| Project/Area Number |
15K10785
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Hasegawa Masahiro 琉球大学, 医学(系)研究科(研究院), 非常勤講師 (10347156)
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| Co-Investigator(Kenkyū-buntansha) |
真栄田 裕行 琉球大学, 医学(系)研究科(研究院), 准教授 (40264501)
山下 懐 琉球大学, 医学(系)研究科(研究院), 助教 (60569622)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 内反性乳頭腫 / 診断 / 再発 / 悪性化 / ヒト乳頭腫ウイルス / 扁平上皮癌抗原 / サロゲートマーカー / ヒト乳頭腫ウイルス感染 / 扁平上皮癌 / 癌化 / セルサイクルプロテイン |
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| Outline of Final Research Achievements |
Squamous cell carcinoma antigen was significantly elevated in inverted papilloma than squamouse cell carcinoma (SCC)and infectious diseases (CRS). Higher viral loads and integration observed in the IP, IP+SCC, and SCC groups.In addtion,an inverse correlation between HPV presence and positive pRb indicated that persistent infection and integration play a part in tumorigenesis and malignant transformation in certain IP cases.Regardless of HPV status, p16INK4a positivity was frequently detected in IP cases (82.4%), less in SCC (12.5%) cases, and was not detected in the CRS group.
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