Regulation of allergic rhinitis with regulatory T cell induced by siRNA
| Project/Area Number |
15K10789
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Suzuki Motohiko 名古屋市立大学, 大学院医学研究科, 教授 (50326138)
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| Co-Investigator(Kenkyū-buntansha) |
飛田 秀樹 名古屋市立大学, 大学院医学研究科, 教授 (00305525)
中村 善久 名古屋市立大学, 大学院医学研究科, 研究員 (90360023)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 制御性T細胞 / siRNA / 制御性Ｔ細胞 |
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| Outline of Final Research Achievements |
siRNA (smalll interfering RNA) can inhibit gene expression specifically. In this study, we showed that antigen-specific regulatory T cells can be induced by CD40 siRNA (siRNA against CD40)-transfected antigen-pulsed dendritic cell in vitro. We also demonstrated regulatory T cells induced by CD40 siRNA-transfected antigen-pulsed dendritic cell inhibited antigen-specific IgE in sera, eosinophilia in nasal mucosa, allergic nasal symptom (the number of sneezes and nasal rub movements) in mice with allergic rhinitis.
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| Academic Significance and Societal Importance of the Research Achievements |
申請者は、誘導された抗原特異的制御性T細胞をアレルギー性鼻炎モデルマウスに投与することにより、血液中抗原特異的IgE、鼻粘膜好酸球、アレルギー性鼻炎症状（くしゃみ発作回数や鼻掻き回数）が抑制されることを証明した。この結果は、本方法により誘導された抗原特異的制御性T細胞がアレルギー反応や症状を抑制し、アレルギー性鼻炎に対する治療手段となる可能性を示している。すなわち、より強力で安全なアレルギー性鼻炎に対する新規治療法として期待できる。
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Report
(5 results)
Research Products
(16 results)
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[Journal Article] Serum periostin as a useful biomarker of comorbid chronic rhinosinusitis in patients with asthma2017
Author(s)
Takamitsu Asano, Yoshihiro Kanemitsu, Masaya Takemura, Makoto Yokota, Kensuk Fukumitsu e, Norihisa Takeda, Hiroya Ichikawa, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Yumi Maki, Junya Ono, Shoichiro Ohta, Yoshihisa Nakamura, Kenji Izuhara, Motohiko Suzuki, and Akio Niimi
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Journal Title
Annals of the American Thoracic Society
Volume: 印刷中
Issue: 5
Pages: 667-675
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The effect of the leukotriene antagonist pranlukast on pediatric acute otitis media.2016
Author(s)
Nakamura Y, Hamajima Y, Suzuki M, Esaki S, Yokota M, Oshika M, Takagi I, Yasui K, Miyamoto N, Sugiyama K, Nakayama M, Murakami S.
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Journal Title
Int J Pediatr Otorhinolaryngol
Volume: 87
Pages: 34-8
Related Report
Peer Reviewed
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[Journal Article] A Pilot Study on the Efficacy of Continuous Positive Airway Pressure on the Manifestations of Ménière's Disease in Patients with Concomitant Obstructive Sleep Apnea Syndrome.2015
Author(s)
Nakayama M, Masuda A, Ando KB, Arima S, Kabaya K, Inagaki A, Nakamura Y, Suzuki M, Brodie H, Diaz RC, Murakami S.
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Journal Title
J Clin Sleep Med.
Volume: 11
Issue: 10
Pages: 1101-7
DOI
Related Report
Peer Reviewed
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