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Relationship between asthmatic respiratory inflammation and abnormal secretion of olfactory mucosa-effect of olfactory dysfunction due to airway remodeling

Research Project

Project/Area Number 15K10790
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionDokkyo Medical University

Principal Investigator

Haruna Shinichi  獨協医科大学, 医学部, 教授 (60198934)

Co-Investigator(Kenkyū-buntansha) 深美 悟  獨協医科大学, 医学部, 准教授 (00311944)
吉田 拓人  獨協医科大学, 医学部, 講師 (80328369)
金谷 洋明  獨協医科大学, 医学部, 講師 (40265301)
Project Period (FY) 2015-10-21 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords嗅粘膜 / NO / 好酸球 / ボーマン腺 / 好酸球性副鼻腔炎 / 嗅覚障害 / 気道リモデリング / リモデリング / 複合糖質 / 嗅粘膜障害 / 嗅粘膜培養 / 分泌過多 / 喘息 / 呼吸粘膜 / りモデリング / ボーマン線
Outline of Final Research Achievements

Histopathological findings of olfactory mucosa in eosinophilic sinusitis showed eosinophil infiltration, growth of Bowman gland and abnormal secretion of Bowman gland. After using oral steroid, eosinophil infiltration and growth of Boman gland were suppressed and most cases with olfactory dysfunction were improved. On the other hand, histopathological eosinophilic infiltration in anterior portion of sinus respiratory mucosa significantly increased more than those in posterior portion. Oral respiratory Nitric acid (FeNO) was found high concentrations in respiratory mucosa with remarkable infiltrative eosinophils and high FeNO concentration was imaged to flow from choana into nasal cavity. Not only cilia damage of the respiratory sinus mucosa, but also olfactory cilia damage and highly secretion of Bowman gland were suggested to be relationship with FeNO. Therefore, olfactory dysfunction in eosinophilic sinusitis was thought to be affected by lower respiratory tract inflammation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2018 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 7 results,  Open Access: 7 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 5 results)

  • [Journal Article] Assessment of suitable reference genes for RT-qPCR studies in chronic rhinosinusitis.2018

    • Author(s)
      Nakayama T, Okada N, Yoshikawa M, Asaka D, Kuboki A, Kojima H, Tanaka Y, Haruna SI.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 1568-1568

    • DOI

      10.1038/s41598-018-19834-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 局所ステロイド処置による好酸球性副鼻腔炎(ECRS)術後の再燃抑制効果2017

    • Author(s)
      今野渉、春名眞一
    • Journal Title

      日鼻誌

      Volume: 56 Pages: 97-102

    • NAID

      130005865215

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Yellow Nail Syndrome with dramatic improvement of nail manifestations after endoscopic sinus surgery2017

    • Author(s)
      Hosokawa Y, Haruna S
    • Journal Title

      Clin Med Insights Ear Nose Throat

      Volume: 5 Pages: 10-10

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A case of falciparum malaria: Acute hearing loss as the initial symptom2017

    • Author(s)
      Tada T, Haruna S
    • Journal Title

      J Infect Chemother

      Volume: 23 Pages: 56-58

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic factors for recurrence after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps.2016

    • Author(s)
      Nakayama T, Asaka D, Kanaya H, Kuboki A, Haruna SI
    • Journal Title

      Auris Nasus Larynx

      Volume: 43 Issue: 6 Pages: 185-189

    • DOI

      10.1016/j.anl.2016.02.015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel scoring system and algorithm for classifying chronic rhinosinusitis: The JESREC Study.2015

    • Author(s)
      Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Yamada K, Okano M, Ohtori N, Yoshikawa M, et al
    • Journal Title

      Allergy

      Volume: Epub ahead of print Issue: 8 Pages: 995-1003

    • DOI

      10.1111/all.12644

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Simple suturing of the nasal septum using the Maniceps septum stitch device.2015

    • Author(s)
      Kuboki A, Yanagi K, Nakayama T, Haruna S
    • Journal Title

      J Laryngol Otol

      Volume: 129 Issue: 6 Pages: 591-4

    • DOI

      10.1017/s0022215115001024

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 好酸球性副鼻腔炎鼻茸組織中のmatrix metalloproteinase-8陽性好中球の検討2017

    • Author(s)
      金谷洋明、春名眞一
    • Organizer
      耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      旭川グランドホテル(北海道旭川市)
    • Year and Date
      2017-04-13
    • Related Report
      2016 Research-status Report
  • [Presentation] PostESS care2017

    • Author(s)
      Haruna Shinichi
    • Organizer
      ISIAN
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Surgical management based on the site of inverted papilloma2017

    • Author(s)
      Haruna Shinichi
    • Organizer
      ICORL
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Surgery of the inverted papilloma2017

    • Author(s)
      Haruna Shinichi
    • Organizer
      TongRen Rhinology Forum
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 上皮細胞間隙のタイトジャンクション2016

    • Author(s)
      金谷洋明、春名眞一
    • Organizer
      日本鼻科学会
    • Place of Presentation
      栃木県総合文化センター(栃木県宇都宮市)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Postoperative results of Eosinophilic rhino sinusitis in Japan2016

    • Author(s)
      SHinichi Haruna
    • Organizer
      East Asia Rhinologic forum
    • Place of Presentation
      China
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 好酸球性副鼻腔炎術後の経口ステロイド薬を減量させる2016

    • Author(s)
      春名眞一
    • Organizer
      日本耳鼻咽喉科学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report
  • [Presentation] 副鼻腔乳頭腫再手術例について2016

    • Author(s)
      春名眞一
    • Organizer
      日本頭頸部外科学会
    • Place of Presentation
      広島
    • Year and Date
      2016-01-28
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-10-21   Modified: 2019-03-29  

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