| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
It is reported that Histamine-Releasing Factor (HRF) binds to a subset of IgE/IgG and is involved in mast cell-dependent allergic reactions. Howevere, it is still unknown whether HRF is involved in other allergic diseases such as pollinosis. The purpose of this study is to investigate the role of HRF in allergic rhinitis/pollinosis. It was shown that only HRF dimer has ability to stimulate HRF-reactive IgE-bound mast cells. Using ragweed pollen-induced pollinosis mouse model, it was observed that HRF treatment inhibited ragweed pollen-induced pollinosis, suggesting that HRF is involved in the allergic rhinitis/pollinosis.
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