Analysis of head and neck cancer control mechanism by CD147 related cell signaling pathway

• Project/Area Number: 15K10796
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Akita University
• Principal Investigator: SUZUKI SHINSUKE 秋田大学, 医学系研究科, 准教授 (90312701)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 頭頸部癌 / CD147 / 転移 / 上皮間葉移行 / EMT / シグナル伝達 / EMMPRIN / 細胞内シグナル伝達

Outline of Final Research Achievements

Studies using squamous cell carcinoma of the tongue cells and clinical specimens indicated that CD147 induces tongue cancer cell invasion through its interaction with S 100 A9, and that expression of CD147 in the invasive tumor front may help predict cervical lymph node metastasis in patients with squamous cell carcinoma of the tongue.
In addition, in the head and neck cancer cell, it was indicated that the cell signal through MEK was activated by the interaction of cyclophilin A and CD147. Furthermore, we confirmed that CD147 is involved in the induction of EMT (Epithelial-mesenchymal transition) and tumor promotion, such as cell migration and invasion, in head and neck squamous cell carcinomas.

Academic Significance and Societal Importance of the Research Achievements

研究結果は頭頸部扁平上皮癌の進展機序を、CD147を中心に解明したものであり、頭頸部扁平上皮癌の治療標的としてCD147が候補となりうることが示された。これらの結果は頭頸部扁平上皮癌の新たな治療法の開発につながり、頭頸部癌患者の生命予後を改善させる可能性を持つ。

Research Products

• [Journal Article] CD147 mediates transforming growth factor-β1-induced epithelial-mesenchymal transition and cell invasion in squamous cell carcinoma of the tongue. (2019)
  • Author(s): Suzuki S, Toyoma S, Tsuji T, Kawasaki Y, Yamada T.
  • Journal Title: Exp Ther Med Volume: 17(4) Pages: 2855-2860
  • DOI: 10.3892/etm.2019.7230
  • Peer Reviewed / Open Access
• [Journal Article] CD147 expression correlates with lymph node metastasis in T1-T2 squamous cell carcinoma of the tongue. (2017)
  • Author(s): Suzuki S, Honda K, Nanjo H, Iikawa N, Tsuji T, Kawasaki Y, Yamazaki K, Sato T, Saito H, Shiina K, Ishikawa K.
  • Journal Title: Oncol Lett Volume: 14 Issue: 4 Pages: 4670-4676
  • DOI: 10.3892/ol.2017.6808
  • Peer Reviewed
• [Presentation] CD147/EMMPRIN mediates TGF-β induced epithelial-mesenchymal transition and migration of head and neck squamous cell carcinoma cells (2018)
  • Author(s): Shinsuke Suzuki
  • Organizer: American Association for Cancer Research Annual Meeting 2018
  • Int'l Joint Research
• [Presentation] 喉頭癌におけるFDG-PET/CTの 原発巣SUVmax値についての検討 (2017)
  • Author(s): 鈴木真輔, 飯川延子, 本田耕平, 川嵜洋平, 辻 正博, 石川和夫3, 山田武千代
  • Organizer: 第29回 日本喉頭科学会
• [Presentation] 線維芽細胞は放射線照射により頭頸部扁平上皮癌の遊走促進能を亢進させる (2017)
  • Author(s): 鈴木真輔、登米 慧、山田武千代
  • Organizer: 第41回日本頭頸部癌学会
• [Presentation] CD147/EMMPRIN mediates TGF-β induced epithelial-mesenchymal transition and HNSCC migration. (2016)
  • Author(s): Shinsuke Suzuki, Satoshi Toyoma, Tadahiro Tsuji, Kazuo Ishikawa
  • Organizer: AHNS 9th International Conference on Head and Neck Cancer.
  • Place of Presentation: シアトル、米国
  • Year and Date: 2016-07-16
  • Int'l Joint Research
• [Presentation] 頭頸部癌の上皮間葉移行におけるCD147/EMMPRINの関与 (2016)
  • Author(s): 鈴木真輔、登米 慧、辻 正博、石川和夫
  • Organizer: 頭頸部癌学会
  • Place of Presentation: 埼玉
  • Year and Date: 2016-06-09
• [Presentation] 下咽頭癌におけるCD147/EMMPRIN発現と予後の検討 (2016)
  • Author(s): 鈴木真輔、本田耕平、山崎一春、川嵜洋平、辻正博、飯川延子、佐藤輝幸、石川和夫
  • Organizer: 日本耳鼻咽喉科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-05-18
• [Presentation] 下咽頭癌におけるCD147/EMMPRIN発現と予後の検討 (2016)
  • Author(s): 鈴木真輔、本田耕平、山崎一春、川嵜洋平、辻 正博、飯川延子、佐藤輝幸、石川和夫
  • Organizer: 第117回日本耳鼻咽喉科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-05-18
• [Presentation] Analysis of signaling pathways induced by CD147/EMMPIN in HNSCC. (2015)
  • Author(s): Shinsuke Suzuki, Kazuo Ishikawa
  • Organizer: 4th Congress of Asian Society of Head and Neck Oncology.
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2015-06-03
  • Int'l Joint Research