| Project/Area Number |
15K10796
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 頭頸部癌 / CD147 / 転移 / 上皮間葉移行 / EMT / シグナル伝達 / EMMPRIN / 細胞内シグナル伝達 |
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| Outline of Final Research Achievements |
Studies using squamous cell carcinoma of the tongue cells and clinical specimens indicated that CD147 induces tongue cancer cell invasion through its interaction with S 100 A9, and that expression of CD147 in the invasive tumor front may help predict cervical lymph node metastasis in patients with squamous cell carcinoma of the tongue.
In addition, in the head and neck cancer cell, it was indicated that the cell signal through MEK was activated by the interaction of cyclophilin A and CD147. Furthermore, we confirmed that CD147 is involved in the induction of EMT (Epithelial-mesenchymal transition) and tumor promotion, such as cell migration and invasion, in head and neck squamous cell carcinomas.
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| Academic Significance and Societal Importance of the Research Achievements |
研究結果は頭頸部扁平上皮癌の進展機序を、CD147を中心に解明したものであり、頭頸部扁平上皮癌の治療標的としてCD147が候補となりうることが示された。これらの結果は頭頸部扁平上皮癌の新たな治療法の開発につながり、頭頸部癌患者の生命予後を改善させる可能性を持つ。
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