Study of the additive effect of refractory head and neck cancer boron neutron capture therapy and combination therapy
Project/Area Number |
15K10797
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
福光 延吉 神戸大学, 医学研究科, 客員准教授 (40277075)
大西 かよ子 筑波大学, 医学医療系, 講師 (60529832)
石川 仁 筑波大学, 医学医療系, 教授 (70344918)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | ホウ素中性子捕捉療法 / 頭頸部癌 / 18F-BPA-PET / 補助療法 / ホウ素中性子補足療法 |
Outline of Final Research Achievements |
BNCT was performed on patients with recurrent refractory head and neck cancer at the University of Tsukuba and chemotherapy or molecular targeting therapy according to each tissue type was added as adjuvant therapy from 4 weeks after irradiation. As a result, the average survival time of 4 cases was 12 months, which was slightly longer than that of the conventional similar report. Although statistical analysis was not possible due to the small number of cases, BNCT for head and neck cancer suggested that prolongation of life prognosis could be prolonged by adding adjuvant therapy according to case after irradiation.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Evaluation of Fluoride-18-Labeled Boronophenylalanine-Positron Emission Tomography Imaging for the Assessment of Boron Neutron Capture Therapy in Patients with Recurrent Head and Neck Squamous Cell Carcinoma.2017
Author(s)
Teruhito A, Jyunichi H, Nobuyoshi F, Hitoshi I, Norimasa M, Hiroaki K, Nobuhiko K, Kayoko O, Minoru S, Hideyuki S, Tamotsu H.
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Journal Title
Otolaryngol (Sunnyvale)
Volume: 6
Related Report
Peer Reviewed
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[Journal Article] Evaluation of fluoride-18-labeled boronophenylalanine-positron emission tomography imaging for the assessment of boron neutron capture therapy in patients with recurrent head and neck squamous cell carcinoma2016
Author(s)
T.Aihara, J.Hiratsuka, N.Fukumitsu, H.Ishikawa, N.Morita, H.Kumada, N.Kamitani, K.Ohnishi, M.Suzuki, H.Sakurai, T.Harada
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Journal Title
Otolaryngology
Volume: 6 (6)
Issue: 06
Pages: 1-5
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Boron-neutron capture therapy for head and neck cancer2015
Author(s)
Teruhito Aihara, Hitoshi Ishikawa, Hiroaki Kumada, Nobuyoshi Fukumitsu, Kayoko Onishi, Junichi Hiratsuka, Tetsuya Yamamoto, Akira Matsumura, Hideyuki Sakurai.
Organizer
PACIFICHEM 2015
Place of Presentation
Hawaii Convention Center (Hawaii)
Year and Date
2015-12-15
Related Report
Int'l Joint Research / Invited
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[Presentation] Overview of the BNCT clinical studies at the University of Tsukuba2015
Author(s)
T. Aihara, H. Ishikawa, K. Ohnishi, H. Kumada, N. Fukumitsu, T. Okumura, M. Mizumoto, H. Numajiri, K. Tanaka, M. Suzuki, H. Sakurai.
Organizer
日本放射線腫瘍学会第28回学術集会
Place of Presentation
ベイシア文化ホール (前橋)
Year and Date
2015-11-19
Related Report
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[Presentation] 筑波大学における頭頸部BNCT臨床研究経過報告2015
Author(s)
粟飯原輝人, 石川仁, 和田哲郎, 福光延吉, 大西かよ子, 中井啓, 長谷川正午, 硲田猛真, 中山雅博, 田渕 経司, 奥村敏之, 鈴木実, 原晃, 櫻井英幸.
Organizer
第53会日本が治療学会学術集会
Place of Presentation
京都国際会議場 (京都)
Year and Date
2015-10-29
Related Report
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[Presentation] 筑波大学における頭頸部BNCT臨床研究経過報告2015
Author(s)
粟飯原輝人, 石川仁, 和田哲郎, 福光延吉, 大西かよ子, 中井啓, 長谷川正午, 硲田猛真, 中山雅博, 田渕経司, 奥村敏之, 鈴木実, 原晃, 櫻井英幸
Organizer
第39回頭頸部癌学会
Place of Presentation
神戸国際会議場 (神戸)
Year and Date
2015-06-03
Related Report
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[Presentation] Overview of the re-start of BNCT clinical studies at the University of Tsukuba2015
Author(s)
T. Aihara, H. Ishikawa, K. Ohnishi, H. Kumada, N. Fukumitsu, T. Okumura, M. Mizumoto, H. Numajiri, K. Tanaka, K. Nakai, T. Yamamoto, A. Matsumura, M. Suzuki, H. Sakurai.
Organizer
15th International Congress of Radiation Research
Place of Presentation
Kyoto International Conference Center (Kyoto)
Year and Date
2015-05-25
Related Report
Int'l Joint Research