Elucidation of the extracellular matrix signal mechanism controled by tumor suppressor microRNAs in head and neck cancer
| Project/Area Number |
15K10800
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Southen Tohoku Research Institute for Neuroscience (2017)
Chiba University (2015-2016) |
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Principal Investigator |
Ichiro Fukumoto 一般財団法人脳神経疾患研究所, 耳鼻咽喉科, 医長 (70748764)
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| Co-Investigator(Kenkyū-buntansha) |
関 直彦 千葉大学, 大学院医学研究院, 准教授 (50345013)
吉川 直子 千葉大学, 医学部附属病院, その他 (50400924)
花澤 豊行 千葉大学, 大学院医学研究院, 准教授 (90272327)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 頭頸部扁平上皮癌 / 癌抑制型マイクロRNA / 癌遺伝子 / マイクロRNA / MET / 細胞外マトリックス |
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| Outline of Final Research Achievements |
Head and neck squamous cell carcinoma(HNSCC) results in cervical lymph node metastasis and distant metastasis and is often discovered as progressive cancer, and the prognosis is very poor. It is difficult to aim at the radical cure for a case resulting in distant metastasis in particular, but the metastatic mechanism is unknown. Recently, about twenty base micro RNAs which do not encode protein has been studied all over the world.
Using a specimen operated at a hospital attached to the Chiba University School of Medicine, we made the downregulated microRNAs profile in HNSCC. Moreover, we identified tumor suppressive microRNAs in the profile, and elucidated the functional roles of cancer metastasis network controlled by the tumor suppressive microRNAs.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma2016
Author(s)
Ichiro Fukumoto, Naoko Kikkawa, Ryosuke Matsushita, Mayuko Kato, Akira Kurozumi, Rika Nishikawa, Yusuke Goto, Keiichi Koshizuka, Toyoyuki Hanazawa, Hideki Enokida, Masayuki Nakagawa, Yoshitaka Okamoto, Naohiko Seki
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Journal Title
Journal of Human Genetics
Volume: 61(2)
Issue: 2
Pages: 109-118
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways.2015
Author(s)
Fukumoto I, Hanazawa T, Kinoshita T, Kikkawa N, Koshizuka K, Goto Y, Nishikawa R, Chiyomaru T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
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Journal Title
Br J Cancer
Volume: 112
Issue: 5
Pages: 891-900
DOI
Related Report
Peer Reviewed / Open Access
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