Analyses of the activation mechanism of latent form TGFbeta in the lymph node metastasis of head and neck squamous cell carcinoma
Project/Area Number |
15K10809
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | Ehime University |
Principal Investigator |
Yano Hajime 愛媛大学, 医学系研究科, 准教授 (00284414)
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Research Collaborator |
Tanaka Junya 愛媛大学, 大学院医学系研究科 分子細胞生理学, 教授
Kaminota Teppai 愛媛大学, 医学部 耳鼻咽喉科・頭頸部外科, 大学院生・医員
Sanada Tomoyoshi 愛媛大学, 医学部 耳鼻咽喉科・頭頸部外科, 大学院生・医員
Hatoh Naohito 愛媛大学, 医学部 耳鼻咽喉科・頭頸部外科, 教授
Yaguchi Haruna 愛媛大学, 医学部, 学生
Nomura Noriko 愛媛大学, 医学部, 学生
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 頭頸部扁平上皮がん / リンパ節転移 / NHE1 / LOXL2 / 集団的細胞運動 / エクソソーム / ナトリウムイオン/プロトン交換輸送体1 / 細胞内 pH / がん浸潤 / がん転移 / ヒト頭頸部扁平上皮がん組織 |
Outline of Final Research Achievements |
Aiming at the prevention of lymph node metastasis of head and neck squamous cell carcinomas, we have been started studying the participation of Sodium ion / proton exchanger 1 (NHE1) on the molecular mechanism of the metastasis, focusing on the recruitment of TGFbeta1 form the latent to the active form. We reached to the presentation of a novel and important concept in the research field of collective cell migration by the finding of the essential participation of NHE1 on the maintenance of this cell migration modality. NHE1 was assumed to participate in the maintenance of planer polarity of the cell migration, however, precise molecular mechanism is still enigmatic. Focusing on intracellular pH, we furthermore found characteristic distribution of pHi among the migrating cell collectives, i.e., higher in the intra and lower in the periphery of the collectives.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Elevated Na+/H+ exchanger-1 expression enhances the metastatic collective migration of head and neck squamous cell carcinoma cells2017
Author(s)
Teppei Kaminota, Hajime Yano, Kohei Shiota, Noriko Nomura, Haruna Yaguchi, Yui Kirino, Kentaro Ohara, Issei Tetsumura, Tomoyoshi Sanada, Toru Ugumori, Junya Tanaka, Naohito Hato
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 486
Issue: 1
Pages: 101-107
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The hypnotic bromovalerylurea ameliorates 6-hydroxydopamine-induced dopaminergic neuron loss while suppressing expression of interferon regulatory factors by microglia2016
Author(s)
Hiromi Higaki, Mohammed Emamussalehin Choudhury, Chisato Kawamoto, Keisuke Miyamoto, Afsana Islam, Yurika Ishii, Kazuya Miyanishi, Haruna Takeda, Naoto Seo, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano and Junya Tanaka
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Journal Title
Neurochemistry International
Volume: 99
Pages: 158-168
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A Truncated form of CD200 (CD200S) Expressed on Glioma Cells Prolonged Survival in a Rat Glioma Model by Induction of a Dendritic Cell-Like Phenotype in Tumor-Associated Macrophages2016
Author(s)
Kana Kobayashi, Hajime Yano, Akihiro Umakoshi, Shirabe Matsumoto, Ayano Mise, Yu Funahashi, Yoshitomo Ueno, Yoshiaki Kamei, Yasutsugu Takada, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanaka
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Journal Title
Neoplasia
Volume: 18
Issue: 4
Pages: 229-241
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na+/H+ exchanger 1 expression2016
Author(s)
Ryutaro Nishioka, Kana Sugimoto, Hitomi Aono, Ayano Mise, Mohammed E. Choudhury, Kazuya Miyanishi, Afsana Islam, Takahiro Fujita, Haruna Takeda, Hisaaki Takahashi, Hajime Yano, Junya Tanaka
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Journal Title
Experimental Neurology
Volume: 277
Pages: 150-161
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] CD200+ and CD 200- macrophages accumulated in ischemic lesions of rat brain: The two populations cannot be classified as either M1 or M2 macrophages2015
Author(s)
Shirabe Matsumoto, Junya Tanaka, Hajime Yano, Hisaaki Takahashi, Kana Sugimoto, Shiro Ohue, Akihiro Inoue, Hitomi Aono, Akari Kusakawa, Hideaki Watanabe, Yoshiaki Kumon, Takanori Ohnishi
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Journal Title
Journal of Neuroimmunology
Volume: 282
Pages: 7-20
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The Ameliorative Effects of a Hypnotic Bromvalerylurea in Sepsis2015
Author(s)
Kikuchi S, Nishihara T, Kawasaki S, Abe N, Kuwabara J, Choudhury ME, Takahashi H, Yano H, Nagaro T, Watanabe Y, Aibiki M, Tanaka J
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Journal Title
Biochem Biophys Res Commun.
Volume: 459
Issue: 2
Pages: 319-326
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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