| Project/Area Number |
15K10814
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Yamashita Yukashi 琉球大学, 医学(系)研究科(研究院), 助教 (60569622)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 頭頸部癌 / アルコール代謝遺伝子 / たばこ代謝遺伝子 / 遺伝子多型 / アルコール代謝関連遺伝子 / たばこ代謝関連遺伝子 / ADH1B, ALDH2 / CYP1A1, GST / ADH1B、ALDH2 / CYP1A1、GST |
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| Outline of Final Research Achievements |
We examined genetic polymorphisms of alcohol metabolism genes ADH1B, ALDH2 and tobacco metabolism genes CYP1A1 MSP I, CYP1A1 Ile 462 Val, GSTM 1, GSTT 1, and GSTP 1 of 29 cases of laryngeal cancer, 67 cases of hypopharyngeal cancer, 123 cases of control group. Genetic polymorphisms with low alcohol metabolism of ADH1B * 1 / * 1 and ALDH2 * 1 / * 2 are risk factors (OR=5.84, OR=9.22) in hypopharyngeal cancer. Genetic polymorphisms with low tobacco metabolism of GSTM1 null is risk factor (OR=3.26) in laryngeal cancer. It was found that there was a difference in polymorphism which is a risk factor in hypopharyngeal cancer and laryngeal cancer.
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