The expression levels of Lysophosphatidic asid receptors in head and neck squamous cell calcinoma.

• Project/Area Number: 15K10815
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: University of the Ryukyus
• Principal Investigator: Matayoshi Sen 琉球大学, 医学部附属病院, 助教 (60448587)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: リゾホスファチジン酸 / LPA / 頭頸部癌 / Gタンパク共役受容体 / リゾフォスファチジン酸 / オートタキシン / 酸性フォスファターゼ

Outline of Final Research Achievements

Lysophosphatidic acids(LPAs) have been implicated in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). We investigated the mRNA expression levels of LPA receptors(LPA1-6), LPA producing enzyme(Autotaxin;ATX) ,and LPA degrading enzyme(ACP6) in HNSCC samples. The expression levels of LPA1 in hypophalynageal carcinoma(HPC) was eight times higher than that of LPA4. Further more, HPC showed high expression level of ATX. Our data suggest that the difference of LPA1 and LPA4 expression may influences malignant beahviors of HNSCCs.