Expression of LOX-1 protein induced by low-oxygen environment and high-concentrated oxygen therapy in head and neck legion
| Project/Area Number |
15K10816
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Maeda Hiroyuki 琉球大学, 医学(系)研究科(研究院), 准教授 (40264501)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 頭頸部癌 / 高濃度酸素療法 / 低酸素誘導タンパク質 / 発癌モデルラット / ロックス１ / LOX-1 / P53 / ｐ５３ |
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| Outline of Final Research Achievements |
We measured expression of LOX-1 protein in cell-line and specimen of head and neck carcinoma. We compared expression of LOX-1 protein malignant tumor with normal tissue in head and neck legion. Moreover, we examined expression of LOX-1 protein in real tissue of head and neck carcinoma by anti-LOX-1 antibody. We acquired results as follows:
LOX-1 protein expressed in each head and neck organ, especially in oropharynx and tongue, with certain quantity. LOX-1 protein prominent expressed in hypopharyngeal and esophageal carcinoma add to oropharyngeal and tongue cancer. Expression of LOX-1 in malignant tumor was significant higher than normal tissue. Expression of LOX-1 protein in recurrent tumor increased clearly compared with untreated tumor. It was clarified that there is not difference of quantity of expression LOX-1 and CyclinD1. Prognosis of the patient having head and neck carcinoma with high expression of LOX-1 protein was better than those without expression of LOX-1 protein.
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Report
(4 results)
Research Products
(31 results)
