Investigation of the mechanism of fibrosis in IgG4-related disease
| Project/Area Number |
15K10818
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
松宮 弘 札幌医科大学, 医学部, 研究員 (80517904)
角木 拓也 札幌医科大学, 医学部, 研究員 (70706548)
金子 躍人 札幌医科大学, 医学部, 研究員 (90738874)
矢島 諒人 札幌医科大学, 医学部, 研究員 (90722455)
垣内 晃人 札幌医科大学, 医学部, 研究員 (60722436)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 唾液腺 / IgG4関連疾患 / 線維化 / 繊維芽細胞 / IL-6 / IgG4関連涙腺・唾液腺炎 / サイトカイン / 顎下腺 / 導管上皮 / タイト結合 / 細胞・組織 / 導管上皮細胞 |
|---|
| Outline of Final Research Achievements |
In GeneChip analysis, mRNAs of IL-6, IL-18, TSLP and MMP1 were highly expressed in the fibroblasts from SMG tissue of patients with IgG4-RD than in normal. The expression and secretion of IL-6 was greatly higher in IgG4-RD SMG fibroblasts than in normal. The expression and the secretion of IL-6 was upregulated by treatment with IL-1β, TNFα or TNFα/TGF-β. NF-κB inhibitor curcumin prevented the secretion and the expression of IL-6 induced by IL-1β or TNFα/TGF-β in the IgG4-RD SMG fibrobasts. Wnt1-inducible signaling protein 1 (WISP1) was also increased in the IgG4-RD SMG fibroblasts than in the normal. Curcumin also prevented WISP1 expression induced by IL-1β or TNFα/TGF-β in the normal. Treatment with IL-6 or WISP1 increased G2/M phase of the SMG fibroblasts in the normal. Expression of TSLP and IL-33 was increased in the IgG4-RD SMG fibroblasts than in the normal.
|
Report
(4 results)
Research Products
(22 results)
-
-
-
-
-
-
[Journal Article] The Behavior and Role of Lipolysis-stimulated Lipoprotein Receptor, a Component of Tricellular Tight Junctions, in Head and Neck Squamous Cell Carcinomas2016
Author(s)
Takano K, Kakuki T, Obata K, Nomura K, Miyata R, Kondo A, Kurose M, Kakiuchi A, Kaneko Y, Kohno T, Himi T, Kojima T
-
Journal Title
Anticancer Res
Volume: 36
Issue: 11
Pages: 5895-5904
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
-
[Journal Article] Validation of the comprehensive diagnostic criteria for IgG4-related disease in a SMART registry2015
Author(s)
Yamamoto M, Shimizu Y, Yajima H, Tabeya T, Suzuki C, Naishiro Y, Takano K, Murakami R, Honda S, Abe T, Himi T, Mukai M, Takahashi H
-
Journal Title
Mod Rheumatol.
Volume: 25
Issue: 2
Pages: 199-204
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
[Journal Article] Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadenitis: Results from the SMART database.2014
Author(s)
Yamamoto M, Yajima H, Takahashi H, Yokoyama Y, Ishigami K, Shimizu Y, Tabeya T, Suzuki C, Naishiro Y, Takano KI, Yamashita K, Hashimoto M, Keira Y, Honda S, Abe T, Suzuki Y, Mukai M,Himi T, Hasegawa T, Imai K, Shinomura Y
-
Journal Title
Mod Rheumatol
Volume: 27
Issue: 2
Pages: 1-6
DOI
Related Report
Peer Reviewed
-
[Journal Article] Identification of relapse predictors in IgG4-related disease using multivariate analysis of clinical data at the first visit and initial treatment.2014
Author(s)
Yamamoto M, Yajima H, Takahashi H, Yokoyama Y, Ishigami K, Shimizu Y, Tabeya T, Suzuki C, Naishiro Y, Takano KI, Yamashita K, Hashimoto M, Keira Y, Honda S, Abe T, Suzuki Y, Mukai M,Himi T, Hasegawa T, Imai K, Shinomura Y
-
Journal Title
Rheumatology
Volume: 54
Issue: 1
Pages: 45-49
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
