| Project/Area Number |
15K10832
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ABE Sachi 山形大学, 医学部, 助教 (90550658)
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| Research Collaborator |
GOTO Sakiko
NARUMI Mari
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 糖尿病黄斑浮腫 / 血管内皮増殖因子（VEGF) / 炎症 / 眼局所薬物治療 / ステロイド薬 / 抗VEGF 薬 / 長期治療成績 / 包括的治療プロトコール / 血管内皮増殖因子 / 炎症分子メカニズム / ステロイド治療 / 増殖糖尿病網膜症 / 硝子体手術 / ステロイド / 血管内皮増殖因子（VEGF） / ステロイドレスポンダーテスト |
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| Outline of Final Research Achievements |
The systemic conditions of diabetic patients such as hyperglycemia and hypertension cause vascular endothelial cell dysfunction of the retina, particularly of blood capillaries, and retinal circulatory dysfunction and ischemia that subsequently damage retinal tissues. These pathological conditions are considered to be the same as the molecular mechanism of inflammation, which includes inflammatory cells (dendritic cells and macrophages ) and many inflammatory cytokines including VEGF. According to these molecular mechanisms, anti-inflammatory corticosteroids have been proved to be effective and safe treatment modalities. Our present research clarified that the ocular topical administration of anti-inflammatory corticosteroid (difluprednate) is useful to treat diabetic retinopathy and diabetic macular edema.
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