Individualized therapy based on the morphological and functional analysis to maintain visual quality of life for glaucomatous patients.
| Project/Area Number |
15K10835
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
長谷部 日 新潟大学, 医歯学総合病院, 講師 (30535167)
栂野 哲哉 新潟大学, 医歯学系, 助教 (70568550)
松岡 尚気 新潟大学, 医歯学系, 助教 (70646265)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | 緑内障性視神経症 / 光干渉断層計（OCT） / 緑内障性黄斑部障害 / 緑内障性視野障害 / 網膜神経節細胞 / Quality of Life (QOL) / 読書能力・運転能力 / 視線解析 / 緑内障 / Quality of life（OCT） / ハンフリー視野 / VFQ-25 Raschスコア / 網膜神経線維層 / OCT血管造影 / 黄斑部毛細血管網 / QOL / 広義・原発開放隅角緑内障（POAG） / ハンフリー視野(HFA) / トラベクレクトミー / レトロスペクティブ / プロスペクティブ / 視線解析装置 / ドライビングシミュレーター |
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| Outline of Final Research Achievements |
Even in the patients with open angle glaucoma (OAG: primary open angle glaucoma and normal tension glaucoma), major part of visual quality of life (QOL) depends on visual acuity. We found that visual field sensitivity in the papillo-macular area, had to be maintained to keep patients’ visual acuity in OAG. En-face images obtained by OCT show the specific pattern of the retinal nerve fiber bundles in OAG patients with good visual acuity. Using this technic, we can estimate visual field in the central 10 degrees from the results by OCT examination.
We performed a questionnaire to evaluate visual QOL, VFQ-25, for OAG patients, and made Rasch scoring. In addition, we developed HDIVF (high density integrated visual field) score by combination of the HFA 24-2 and 10-2 results in both eye. We found that HDIVF score was one of the best indexes to evaluate visual QOL in OAG patients because of strong correlation with the Rasch score of VFQ-25.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] The effect of concentric constriction of the visual field to 10 and 15 degrees on simulated motor vehicle accidents.2018
Author(s)
Udagawa S, Ohkubo S, Iwase A, Susuki Y, Kunimatsu-Sanuki S, Fukuchi T, Matsumoto C, Ohno Y, Ono H, Sugiyama K, Araie M.
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Journal Title
PLoS One.
Volume: 13(3)
Issue: 3
Pages: e0193767-e0193767
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] The role of specific visual subfields in collisions with oncoming cars during simulated driving in patients with advanced glaucoma.2017
Author(s)
Kunimatsu-Sanuki S, Iwase A, Araie M, Aoki Y, Hara T, Fukuchi T, Udagawa S, Ohkubo S, Sugiyama K, Matsumoto C, Nakazawa T, Yamaguchi T, Ono H.
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Journal Title
Br J Ophthalmol.
Volume: 101(7)
Issue: 7
Pages: 896-901
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 緑内障診療データの管理と共通化の現状とデータ共通化に向けての取り組み2016
Author(s)
柏木 賢治, 相原 一, 稲谷 大, 岩瀬 愛子, 川瀬 和秀, 杉山 和久, 中澤 徹, 中村 誠, 福地 健郎, 吉冨 健志, 新家 眞
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Journal Title
日本眼科学会雑誌
Volume: 120
Pages: 540-547
Related Report
Peer Reviewed
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