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Individualized therapy based on the morphological and functional analysis to maintain visual quality of life for glaucomatous patients.

Research Project

Project/Area Number 15K10835
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionNiigata University

Principal Investigator

Fukuchi Takeo  新潟大学, 医歯学系, 教授 (90240770)

Co-Investigator(Kenkyū-buntansha) 長谷部 日  新潟大学, 医歯学総合病院, 講師 (30535167)
栂野 哲哉  新潟大学, 医歯学系, 助教 (70568550)
松岡 尚気  新潟大学, 医歯学系, 助教 (70646265)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords緑内障性視神経症 / 光干渉断層計(OCT) / 緑内障性黄斑部障害 / 緑内障性視野障害 / 網膜神経節細胞 / Quality of Life (QOL) / 読書能力・運転能力 / 視線解析 / 緑内障 / Quality of life(OCT) / ハンフリー視野 / VFQ-25 Raschスコア / 網膜神経線維層 / OCT血管造影 / 黄斑部毛細血管網 / QOL / 広義・原発開放隅角緑内障(POAG) / ハンフリー視野(HFA) / トラベクレクトミー / レトロスペクティブ / プロスペクティブ / 視線解析装置 / ドライビングシミュレーター
Outline of Final Research Achievements

Even in the patients with open angle glaucoma (OAG: primary open angle glaucoma and normal tension glaucoma), major part of visual quality of life (QOL) depends on visual acuity. We found that visual field sensitivity in the papillo-macular area, had to be maintained to keep patients’ visual acuity in OAG. En-face images obtained by OCT show the specific pattern of the retinal nerve fiber bundles in OAG patients with good visual acuity. Using this technic, we can estimate visual field in the central 10 degrees from the results by OCT examination.
We performed a questionnaire to evaluate visual QOL, VFQ-25, for OAG patients, and made Rasch scoring. In addition, we developed HDIVF (high density integrated visual field) score by combination of the HFA 24-2 and 10-2 results in both eye. We found that HDIVF score was one of the best indexes to evaluate visual QOL in OAG patients because of strong correlation with the Rasch score of VFQ-25.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (43 results)

All 2018 2017 2016 2015

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 7 results) Presentation (28 results) (of which Int'l Joint Research: 11 results,  Invited: 6 results) Book (3 results)

  • [Journal Article] The effect of concentric constriction of the visual field to 10 and 15 degrees on simulated motor vehicle accidents.2018

    • Author(s)
      Udagawa S, Ohkubo S, Iwase A, Susuki Y, Kunimatsu-Sanuki S, Fukuchi T, Matsumoto C, Ohno Y, Ono H, Sugiyama K, Araie M.
    • Journal Title

      PLoS One.

      Volume: 13(3) Issue: 3 Pages: e0193767-e0193767

    • DOI

      10.1371/journal.pone.0193767

    • NAID

      120006452372

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 緑内障診療ガイドライン(第4版)2018

    • Author(s)
      谷原秀信、福地健郎、他
    • Journal Title

      日本眼科学会雑誌

      Volume: 122(1) Pages: 5-53

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of specific visual subfields in collisions with oncoming cars during simulated driving in patients with advanced glaucoma.2017

    • Author(s)
      Kunimatsu-Sanuki S, Iwase A, Araie M, Aoki Y, Hara T, Fukuchi T, Udagawa S, Ohkubo S, Sugiyama K, Matsumoto C, Nakazawa T, Yamaguchi T, Ono H.
    • Journal Title

      Br J Ophthalmol.

      Volume: 101(7) Issue: 7 Pages: 896-901

    • DOI

      10.1136/bjophthalmol-2016-308754

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Additive effects and safety of fixed combination therapy with 1% brinzolamide and 0.5% timolol versus 1% dorzolamide and 0.5% timolol in prostaglandin-treated glaucoma patients.2017

    • Author(s)
      Aihara M, Adachi M, Matsuo H, Togano T, Fukuchi T, Sasaki N; JAC Study group.
    • Journal Title

      Acta Ophthalmol.

      Volume: 95(8) Issue: 8

    • DOI

      10.1111/aos.13401

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluating Silent Reading Performance with an Eye Tracking System in Patients with Glaucoma.2017

    • Author(s)
      Murata N, Miyamoto D, Togano T, Fukuchi T.
    • Journal Title

      PLoS One.

      Volume: 12(1) Issue: 1 Pages: e0170230-e0170230

    • DOI

      10.1371/journal.pone.0170230

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 広義・原発開放隅角緑内障眼の中心窩閾値と矯正視力、傍中心窩視野感度閾値の相関2017

    • Author(s)
      本間 友里恵, 栂野 哲哉, 宮本 大輝, 坂上 悠太, 五十嵐 遼子, 福地 健郎
    • Journal Title

      あたらしい眼科

      Volume: 34(11) Pages: 1617-1621

    • NAID

      40021388852

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Humphrey視野計10-2プログラム異常点数と黄斑部網膜内層厚セクター判定との相関2017

    • Author(s)
      栂野 哲哉, 平島 みほ, 末武 亜紀, 坂上 悠太, 飯川 龍, 本間 友里恵, 福地 健郎
    • Journal Title

      あたらしい眼科

      Volume: 34(10) Pages: 1465-1469

    • NAID

      40021372690

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soemmerring輪を伴う続発閉塞隅角症の2例2017

    • Author(s)
      福武 慈, 坂上 悠太, 栂野 哲哉, 五十嵐 遼子, 長谷部 日, 福地 健郎
    • Journal Title

      あたらしい眼科

      Volume: 34(7) Pages: 1054-1059

    • NAID

      40021278726

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical evaluation of microcystic macular edema in patients with glaucoma.2016

    • Author(s)
      Murata N, Togano T, Miyamoto D, Ochiai S, Fukuchi T.
    • Journal Title

      Eye

      Volume: 30 Issue: 11 Pages: 1502-1508

    • DOI

      10.1038/eye.2016.190

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of intraocular pressure adjusted by central corneal thickness or corneal biomechanical properties as measured in glaucomatous eyes using noncontact tonometers and the Goldmann applanation tonometer.2016

    • Author(s)
      Yaoeda K, Fukushima A, Shirakashi M, Fukuchi T.
    • Journal Title

      Clin Ophthalmol

      Volume: - Pages: 829-829

    • DOI

      10.2147/opth.s106836

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 緑内障診療データの管理と共通化の現状とデータ共通化に向けての取り組み2016

    • Author(s)
      柏木 賢治, 相原 一, 稲谷 大, 岩瀬 愛子, 川瀬 和秀, 杉山 和久, 中澤 徹, 中村 誠, 福地 健郎, 吉冨 健志, 新家 眞
    • Journal Title

      日本眼科学会雑誌

      Volume: 120 Pages: 540-547

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rate of progression of total, upper, and lower visual field defects in patients with open-angle glaucoma and high myopia.2016

    • Author(s)
      Yoshino T, Fukuchi T, Togano T, Sakaue Y, Seki M, Tanaka T, Ueda J.
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 60 Issue: 2 Pages: 78-85

    • DOI

      10.1007/s10384-016-0427-3

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Correlation Between Foveal Avascular Zone (FAZ) Detected by OCT Angiography and Inner Retinal Thickness, or Visual Filed Defects in POAG/NTG patients.2018

    • Author(s)
      Takeo Fukuchi, Ryoko Igarashi, Shun Ochiai, Tetsuya Togano, Yuta Sakaue, Ryu Iikawa, Aki Suetake.
    • Organizer
      13th EGS Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison between estimated central 10 degrees visual field from En-face imaging of Swept-Source optical coherence tomography and Humphrey 10-2 Visual Field.2018

    • Author(s)
      Ryu Iikawa, Tetsuya Togano, Yuta Sakaue, Aki Suetake, Ryoko lgarashi, Takeo Fukuchi.
    • Organizer
      ARVO 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SS-OCT En-face画像と中心裔閾値・網膜内層厚との関連2018

    • Author(s)
      飯川龍、栂野哲哉、坂上悠太、末武亜紀、五十嵐遼子、宮本大輝、福地健郎
    • Organizer
      第122回日本眼科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 緑内障の構造・視野に関する前向き観察研究におけるクラスタ別視野進行と乳頭出血2017

    • Author(s)
      福地健郎、栂野哲哉、谷原秀信、東出朋巳、大久保真司、宇田川さち子、杉山和久、新家眞、富田剛司、松本長太、富所敦男、板谷正紀
    • Organizer
      第71回日本臨床眼科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 緑内障患者の視野とQOL を理解する2017

    • Author(s)
      福地健郎
    • Organizer
      第71回日本臨床眼科学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Flow density and disappeared angle of the peripapillary capillaries quantified by OCT angiography might be structural indexes in OAG eyes2017

    • Author(s)
      Fukuchi T, Igarashi R, Ochiai S, Togano T, Sakaue Y, Iikawa R, Suetake A, Honma Y.
    • Organizer
      WGC 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship Between Vfq25 Score And Mean Sensitivity Of Integrated Visual Field With Weighting Corresponding To The Location.2017

    • Author(s)
      Tetsuya Togano, Takeo Fukuchi, Aki Suetake, Ryu Iikawa, Yuta Sakaue
    • Organizer
      WGC 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of steep Trendelenburg positioning during robot-assisted laparoscopic radical prostatectomy in glaucoma patients2017

    • Author(s)
      Yuta Sakaue, Aki Suetake, Ryu Iikawa, Tetsuya Togano, Itsuhiro Takizawa, Takashi Kasahara, Tsutomu Nishiyama, Yoshihiko Tomita, Takeo Fukuchi
    • Organizer
      WGC 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Observation of retinal nerve fiber bundles of segmental optic nerve hypoplasla with swept-source OCT en-face imaging and comparison with SD-OCT.2017

    • Author(s)
      Ryu likawa, Satoshi Ueki, Tetsuhisa Hatase, Tetsuya Togano, Yuta Sakaue, Aki Suetake, Ryoko lgarashi, Daiki Miyamoto, Takeo Fukuchi
    • Organizer
      WGC 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Correlation between structure and function each cluster of test points within the central 10 degrees in glaucoma2017

    • Author(s)
      Sakaue Yuta, Togano Tetsuya, Suetake Aki, Iikawa Ryu, Igarashi Ryoko, Ochiai Shun, Fukuchi Takeo
    • Organizer
      ARVO 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 緑内障における黄斑部視野の評価2017

    • Author(s)
      坂上悠太、福地健郎
    • Organizer
      第121回日本眼科学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] OCTによる黄斑部の観察と視力・視野2017

    • Author(s)
      飯川龍、福地健郎
    • Organizer
      第28回日本緑内障学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 緑内障における黄斑部血流と視野の解析2017

    • Author(s)
      五十嵐遼子、福地健郎
    • Organizer
      第28回日本緑内障学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Glaucoma surgeonをプロデュースする2017

    • Author(s)
      福地健郎
    • Organizer
      第40回日本眼科手術学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 広義・原発開放隅角緑内障眼の中心窩視機能の指標としての黄斑部網膜内層厚測定2016

    • Author(s)
      福地健郎、坂上悠太、栂野哲哉、末武亜紀、飯川 龍、五十嵐遼子、落合竣
    • Organizer
      第70回日本臨床眼科学会総会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都(京都府京都市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] QOLを意識して視野を探求する2016

    • Author(s)
      福地健郎
    • Organizer
      第27回日本緑内障学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-09-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 広義・原発開放隅角緑内障のOCT angiographyによる黄斑部血管密度と、網膜内層厚、視野感度閾値の相関2016

    • Author(s)
      福地健郎、落合 竣、五十嵐遼子、飯川龍、栂野哲哉、坂上悠太、末武亜紀
    • Organizer
      第27回日本緑内障学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-09-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Cluster Classification of HFA 10-2 Test Points and the Relationship between Structure and Function in Glaucoma.2016

    • Author(s)
      Fukuchi T, Ochiai S, Sakaue Y, Togano T, Igarashi R, Suetake A.
    • Organizer
      12th EGS Congress
    • Place of Presentation
      プラハ(チェコ共和国)
    • Year and Date
      2016-06-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Measurements of the inner Macular Thickness As an Indicator to Evaluate Foveal Visual Function in Open-angle Glaucoma.2016

    • Author(s)
      Fukuchi T, Ochiai S, Sakaue Y, Togano T, Suetake A, Igarashi R.
    • Organizer
      ARVO 2016
    • Place of Presentation
      シアトル(アメリカ合衆国)
    • Year and Date
      2016-05-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 手術治療を要した落屑緑内障症例の臨床的特徴2015

    • Author(s)
      中野英之、栂野哲哉、坂上悠太、平島みほ、末武亜紀、福地健郎
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Quality of Vision に基づく進行判定と評価2015

    • Author(s)
      栂野哲哉、澤田英子、石井雅子、坂上悠太、末武亜紀、福地健郎
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] SS-OCTによる視神経部分低形成の網膜神経線維束観察と緑内障性視神経症との鑑別2015

    • Author(s)
      飯川龍、植木智志、畑瀬哲尚、栂野哲哉、宮本大輝、福地健郎
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 広義原発開放隅角緑内障眼の中心窩閾値と視力、HFAlO-2の相関:病型別等価球面別検討2015

    • Author(s)
      本間友里恵、末武亜紀、栂野哲哉、坂上悠太、宮本大輝、五十嵐遼子、平島みほ、芳野高子、福地健郎
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] SD-OCTによる広義、原発開放隅角緑内障眼の乳頭内および乳頭周囲毛細血管網の観察2015

    • Author(s)
      落合俊、栂野哲哉、末武亜紀、佐々木藍季子、福武慈、本間友里恵、宮本大輝、福地健郎
    • Organizer
      第26回日本緑内障学会
    • Place of Presentation
      ウィンク愛知(愛知県、名古屋市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] シラスOCTコンボレポートの有用性2015

    • Author(s)
      栂野哲哉、平島みほ、末武亜紀、坂上悠太、佐々木藍季子、本間友里恵、福地健郎
    • Organizer
      第26回日本緑内障学会
    • Place of Presentation
      ウィンク愛知(愛知県、名古屋市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Cluster classification of HFA 10-2 test points based on their correlation with the foveal threshold.2015

    • Author(s)
      Fukuchi T, Honma Y, Togano T, Sakaue Y, Hirashima M, Igarashi R, Yoshino T, Miyamoto D
    • Organizer
      World Glaucoma Congress 2015
    • Place of Presentation
      中国、香港
    • Year and Date
      2015-06-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Features of Glaucomatous Retinal Nerve Fiber Bundles Observed by En-face Swept-Source Optical Coherence2015

    • Author(s)
      Fukuchi T, Togano T, Sakaue Y, Hirashia M, Igarashi R, Yoshino T.
    • Organizer
      ARVO
    • Place of Presentation
      アメリカ、デンバー
    • Year and Date
      2015-05-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 視線解析装置を用いた緑内障患者と健常者の読書評価2015

    • Author(s)
      村田憲章、宮本大輝、栂野哲哉、坂上悠太、末武亜紀、本間友里恵、福地健郎
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      さっぽろ芸術文化の館、札幌市教育文化会館(北海道、札幌市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report
  • [Book] 日常診療に活かす診療ガイドラインUP-TO-DATE 2018-20192018

    • Author(s)
      福地健郎
    • Total Pages
      1064
    • Publisher
      メディカルレビュー社
    • ISBN
      9784779220081
    • Related Report
      2017 Annual Research Report
  • [Book] 日常診療に活かす診療ガイドラインUP-TO-DATE 2016-20172016

    • Author(s)
      福地健郎
    • Total Pages
      968
    • Publisher
      メディカルレビュー社
    • Related Report
      2016 Research-status Report
  • [Book] 今日の眼疾患治療指針2016

    • Author(s)
      福地健郎
    • Total Pages
      960
    • Publisher
      医学書院
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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