Utilization of NDB in ophthalmology, especially in diabetic complications.

• Project/Area Number: 15K10839
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: HIROSHI TAMURA 京都大学, 国際高等教育院, 特定教授 (40418760)
• Co-Investigator(Kenkyū-buntansha): 黒田 知宏 京都大学, 医学研究科, 教授 (10304156) ; 加藤 源太 京都大学, 医学研究科, 助教(移行) (20571277) ; 後藤 励 慶應義塾大学, 経営管理研究科(日吉), 准教授 (10411836) ; 岡本 和也 京都大学, 情報学研究科, 研究員 (60565018) ; 浦西 友樹 大阪大学, 基礎工学研究科, 助教 (00533738)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: レセプト / サンプリングデータセット / 糖尿病 / 合併症 / 眼合併症

Outline of Final Research Achievements

Importance was pointed out from several aspects such as medical cost optimization and personalized medicine. Japanese health insurance database(NDB) analysis with high attention for use in research was carried out for diabetic complications.
Comprehensive grasp of actual conditions of ophthalmic laser therapy and grasp of the actual situation of antihypertensive treatment for hypertensive patients with diabetes mellitus. We could also investigate factors such as hypertension and dyslipidemia for the examination of ocular fundus for type 2 diabetic patients.Approximately 30% of the examination of ocular fundus within one year after the start of drug treatment for diabetes mellitus, diabetic patients with comorbidities was found to have a low ratio of ocular fundus examination, especially in patients with co-morbidity and those treated at the same facility .It was also possible to construct an analytical database for epidemiologic research using NDB.

Research Products

• [Journal Article] Nationwide survey of severe postpartum haemorrhage in Japan: an exploratory study using the national database of health insurance claims. (2018)
  • Author(s): Sato Mai, Kondoh Eiji, Iwao Tomohide, Hiragi Shusuke, Okamoto Kazuya, Tamura Hiroshi, Mogami Haruta, Chigusa Yoshitsugu, Kuroda Tomohiro, Mandai Masaki, Konishi Ikuo, Kato Genta
  • Journal Title: The Journal of Maternal-Fetal & Neonatal Medicine Volume: - Issue: 21 Pages: 1-151
  • DOI: 10.1080/14767058.2018.1465921
  • Peer Reviewed / Open Access
• [Journal Article] Influence of Japan’s 2004 postgraduate training on ophthalmologist location choice, supply and distribution (2018)
  • Author(s): Sakai-Bizmark Rie、Goto Rei、Hiragi Shusuke、Tamura Hiroshi
  • Journal Title: BMC Medical Education Volume: 18 Issue: 1 Pages: 265-276
  • DOI: 10.1186/s12909-018-1147-9
  • NAID: 120007185932
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Acetaminophen administration and the risk of acute kidney injury: a self-controlled case series study. (2018)
  • Author(s): Hiragi S, Yamada H, Tsukamoto T, Yoshida K, Kondo N, Matsubara T, Yanagita M, Tamura H, Kuroda T.
  • Journal Title: Clin Epidemiol Volume: 10 Pages: 265-276
  • DOI: 10.2147/clep.s158110
  • Peer Reviewed / Open Access
• [Journal Article] Pachychoroid Geographic Atrophy: Clinical and Genetic Characteristics (2018)
  • Author(s): 10.Takahashi A, Ooto S, Yamashiro K, Tamura H, Oishi, A, Miyata M, Hata M, Yoshikawa M, Yoshimura N, Tsujikawa A.
  • Journal Title: Ophthalmology Retina Volume: in press Issue: 4 Pages: 295-305
  • DOI: 10.1016/j.oret.2017.08.016
  • Peer Reviewed
• [Journal Article] Influence of comorbidities on the implementation of the fundus examination in patients with newly diagnosed type 2 diabetes (2017)
  • Author(s): Kawamura Taichi、Sato Izumi、Tamura Hiroshi、Nakao Yoko M.、Kawakami Koji
  • Journal Title: Japanese Journal of Ophthalmology Volume: 62 Issue: 1 Pages: 68-76
  • DOI: 10.1007/s10384-017-0551-8
  • NAID: 210000178927
  • Peer Reviewed
• [Journal Article] Analysis of the evidence-practice gap to acilitate proper medical care for the lderly: investigation, using databases, of utilization measures for National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) (2017)
  • Author(s): Nakayama T, Imanaka Y, Okuno Y, Kato G, Kuroda T,et al.
  • Journal Title: Environmental Health and Preventive Medicine Volume: 未定 Issue: 1 Pages: 99-99
  • DOI: 10.1186/s12199-017-0644-5
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of clinical symptoms and ABCC6 mutations in 76 Japanese patients with pseudoxanthoma elasticum. (2017)
  • Author(s): Iwanaga A, Okubo Y, Yozaki M, Koike Y, Kuwatsuka Y, Tomimura S, Yamamoto Y, Tamura H, Ikeda S, Maemura K, Tsuiki E, Kitaoka T, Endo Y, Mishima H, Yoshiura KI, Ogi T, Tanizaki H, Wataya-Kaneda M, Hattori T, Utani A.
  • Journal Title: Journal of Dermatology Volume: 印刷中 Issue: 6 Pages: 644-650
  • DOI: 10.1111/1346-8138.13727
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pigment Epithelial Atrophy after Anti-Vascular Endothelial Growth Factor Injections for Retinal Angiomatous Proliferation. (2017)
  • Author(s): Hata M, Yamashiro K, Oishi A, Ooto S, Tamura H, Miyata M, Ueda-Arakawa N, Kuroda Y, Takahashi A, Tsujikawa A, Yoshimura
  • Journal Title: Retina Volume: 未定 Issue: 11 Pages: 2069-2077
  • DOI: 10.1097/iae.0000000000001457
  • Peer Reviewed
• [Journal Article] Recurrence of Choroidal Neovascularization Lesion Activity after Aflibercept Treatment for Age-Related Macular Degeneration. (2017)
  • Author(s): Wakazono T, et al.
  • Journal Title: Retina Volume: 未定
  • Peer Reviewed
• [Journal Article] INCIDENCE AND CAUSES OF VISION LOSS DURING AFLIBERCEPT TREATMENT FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: ONE-YEAR FOLLOW-UP. (2017)
  • Author(s): Hata M, Oishi A, Yamashiro K, Ooto S, Tamura H, Nakanishi H, Ueda-Arakawa N, Akagi-Kurashige Y, Kuroda Y, Takahashi A, Tsujikawa A, Yoshimura N.
  • Journal Title: Retina. Volume: 未定
  • Peer Reviewed
• [Journal Article] Intraocular Vascular Endothelial Growth Factor Levels in Pachychoroid Neovasculopathy and Neovascular Age-Related Macular DegenerationIntraocular VEGF in nAMD. (2016)
  • Author(s): Hata M, Yamashiro K, Ooto S, Oishi A, Tamura H, Miyata M, Ueda-Arakawa N, Takahashi A, Tsujikawa A, Yoshimura N.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 58 Issue: 1 Pages: 292-298
  • DOI: 10.1167/iovs.16-20967
  • Peer Reviewed
• [Journal Article] Assessment of quality of life in patients with visual impairments using a new visual function questionnaire: the VFQ-J11. (2016)
  • Author(s): Nakano T, Kawashima M, Hiratsuka Y, Tamura H, Ono K, Murakami A, Tsubota K, Yamada M.
  • Journal Title: Clin Ophthalmol. Volume: 10 Pages: 1939-1944
  • NAID: 120005997822
  • Peer Reviewed
• [Journal Article] Clinical and Genetic Characteristics of Japanese AgeRelated Macular Degeneration Patients with Pseudodrusen (2016)
  • Author(s): Elfandi S, Ooto S, UedaArakawa N, Takahashi A, Yoshikawa M, Nakanishi H, Tamura H, Oishi A, Yamashiro K, Yoshimura N
  • Journal Title: Ophthalmology Volume: 2016 Issue: 10 Pages: 2205-12
  • DOI: 10.1016/j.ophtha.2016.06.052
  • Peer Reviewed
• [Journal Article] Increased Choroidal Vascularity in Central Serous Chorioretinopathy Quantified Using SweptSource Optical Coherence Tomography (2016)
  • Author(s): Kuroda Y, Ooto S, Yamashiro K, Oishi A, Nakanishi H, Tamura H, UedaArakawa N, Yoshimura N
  • Journal Title: Am J Ophthalmol Volume: 2016 Pages: 199-207
  • DOI: 10.1016/j.ajo.2016.06.043
  • Peer Reviewed
• [Journal Article] Photoreceptor Damage and Reduction of Retinal Sensitivity Surrounding Geographic Atrophy in Agerelated Macular Degeneration (2016)
  • Author(s): Takahashi A, Ooto S, Yamashiro K, Oishi A, Tamura H, Nakanishi H, UedaArakawa N, Tsujikawa A, Yoshimura N
  • Journal Title: Am J Ophthalmol Volume: 2016 Pages: 260-8
  • DOI: 10.1016/j.ajo.2016.06.006
  • Peer Reviewed
• [Journal Article] Defining a Minimum Set of Standardized Patientcentered Outcome Measures for Macular Degeneration (2016)
  • Author(s): Rodrigues IA, Sprinkhuizen SM, Barthelmes D, Blumenkranz M, Cheung G, Haller J, Johnston R, Kim R, Klaver C, McKibbin M, Ngah NF, Pershing S, Shankar D, Tamura H, Tufail A, Weng CY, Westborg I, Yelf C, Yoshimura N, Gillies MC
  • Journal Title: Am J Ophthalmol Volume: 2016 Pages: 1-12
  • DOI: 10.1016/j.ajo.2016.04.012
  • Peer Reviewed
• [Journal Article] The association between legal Japanese visual impairment grades and vision-related quality of life. (2016)
  • Author(s): Kawashima M, Hiratsuka Y, Nakano T, Tamura H, Ono K, Murakami A, Inoue S, Tsubota K, Yamada M.
  • Journal Title: Jpn J Ophthalmol. Volume: 60 Issue: 3 Pages: 219-25
  • DOI: 10.1007/s10384-016-0437-1
  • Peer Reviewed
• [Journal Article] Detection of Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography. (2016)
  • Author(s): Miyata M, Ooto S, Hata M, Yamashiro K, Tamura H, Akagi-Kurashige Y, Nakanishi H, Ueda-Arakawa N, Takahashi A, Kuroda Y, Wakazono T, Yoshikawa M, Yoshimura N.
  • Journal Title: Am J Ophthalmol. Volume: 165 Pages: 108-14
  • DOI: 10.1016/j.ajo.2016.03.009
  • Peer Reviewed
• [Journal Article] Estimation of the Degree of Endolymphatic Hydrops Using Optical Coherence Tomography (2016)
  • Author(s): Karvonen T, Uranishi Y, Sakamoto T, Tona Y, Okamoto K, Tamura H, Kuroda T.
  • Journal Title: Advanced Biomedical Engineering Volume: 5 Issue: 0 Pages: 19-25
  • DOI: 10.14326/abe.5.19
  • NAID: 130005133196
  • ISSN: 2187-5219
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Retinal Pigment Epithelial Atrophy in Neovascular Age-Related Macular Degeneration After Ranibizumab Treatment. (2016)
  • Author(s): Kuroda Y, Yamashiro K, Tsujikawa A, Ooto S, Tamura H, Oishi A, Nakanishi H, Miyake M, Yoshikawa M, Yoshimura N.
  • Journal Title: Am J Ophthalmol. Volume: 161 Pages: 94-103
  • DOI: 10.1016/j.ajo.2015.09.032
  • Peer Reviewed / Open Access
• [Journal Article] Pachychoroid neovasculopathy and age-related macular degeneration. (2015)
  • Author(s): Miyake M, Ooto S, Yamashiro K, Takahashi A, Yoshikawa M, Akagi-Kurashige Y, Ueda-Arakawa N, Oishi A, Nakanishi H, Tamura H, Tsujikawa A, Yoshimura N.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 16204-16204
  • DOI: 10.1038/srep16204
  • NAID: 120005758236
  • Peer Reviewed / Open Access
• [Journal Article] The Contribution of Genetic Architecture to the 10-Year Incidence of Age-Related Macular Degeneration in the Fellow Eye. (2015)
  • Author(s): Miyake M, Yamashiro K, Tamura H, Kumagai K, Saito M, Sugahara-Kuroda M, Yoshikawa M, Oishi M, Akagi-Kurashige Y, Nakata I, Nakanishi H, Gotoh N, Oishi A, Matsuda F, Yamada R, Khor CC, Kurimoto Y, Sekiryu T, Tsujikawa A, Yoshimura N.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 56 Issue: 9 Pages: 5353-5361
  • DOI: 10.1167/iovs.14-16020
  • Peer Reviewed
• [Journal Article] The clinical effectiveness and cost-effectiveness of screening for age-related macular. degeneration in Japan: A Markov modeling study (2015)
  • Author(s): Tamura H, Goto R, Akune Y, Hiratsuka Y, Hiragi, S, Yamada M.
  • Journal Title: PLoS ONE Volume: 10
  • NAID: 120005678207
  • Peer Reviewed / Open Access
• [Journal Article] Factors Associated with Recurrence of Age-related Macular Degeneration after Anti-VEGF Treatment: A Retrospective Cohort Study. (2015)
  • Author(s): Kuroda Y, Yamashiro K, Miyake M, Yoshikawa M, Nakanishi H, Oishi A, Tamura H, Ooto S, Tsujikawa A, Yoshimura N.
  • Journal Title: Ophthalmology. Volume: 122 Issue: 11 Pages: 2303-10
  • DOI: 10.1016/j.ophtha.2015.06.053
  • Peer Reviewed
• [Journal Article] One-year result of aflibercept treatment in age-related macular degeneration and predictive factors for visual outcome. (2015)
  • Author(s): Oishi A, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Nakanishi H, Ueda-Arakawa N, Miyake M, Akagi-Kurashige Y, Hata M, Yoshikawa M, Kuroda Y, Takahashi A, Yoshimura N.
  • Journal Title: Am J Ophthalmol. Volume: 158 Issue: 5 Pages: 853-60
  • DOI: 10.1016/j.ajo.2015.01.018
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evaluating the Effect of Japan's 2004 Postgraduate Training Program on the Spatial Distribution of Physicians. (2015)
  • Author(s): Sakai R, Tamura H, Goto R, Kawachi I.
  • Journal Title: Human Resources for Health Volume: 13 Issue: 1 Pages: 5-5
  • DOI: 10.1186/1478-4491-13-5
  • Peer Reviewed / Open Access
• [Presentation] EQ5D5Lを用いた腎移植医療におけるQOL評価 (2017)
  • Author(s): 平木秀輔, 小林 恭, 田村 寛, 後藤 励, 田中友加里, 澤田篤郎, 坂井 薫, 宮田仁美, 柳田素子, 黒田知宏.
  • Organizer: 第50回日本臨床腎移植学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] An introduction of the database of health insurance claims in Japan. (2016)
  • Author(s): Genta KATO, Shusuke HIRAGI, Tomohide IWA0, Kazuya OKAMOTO, Hisashi SAIT0, Hiroshi TAMURA, Tomohiro KURODA.
  • Organizer: The 1st Asian Researcher Symposium 2016 Asian Role in Sustainable World Development
  • Place of Presentation: West Java,Indonesia
  • Year and Date: 2016-04-24
  • Int'l Joint Research / Invited
• [Presentation] The Validity of Markov Model for the Prognostic Estimation of Chronic Kidney Disease (2016)
  • Author(s): Hiragi S, Tamura H, Goto R, Kuroda T.
  • Organizer: ISPOR 7th Asia-Pacific Conference
  • Place of Presentation: Singapole
  • Int'l Joint Research
• [Presentation] レセプト情報サンプリングデータセットを用いた高血圧治療実態の検討. (2016)
  • Author(s): 平木秀輔, 田村寛, 加藤源太, 塚本達雄, 柳田素子, 黒田知宏.
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 全国レセプトデータ(NDB)を用いた糖尿病合併高血圧患者に対する降圧治療についての検討. (2016)
  • Author(s): 平木秀輔, 田村寛, 加藤源太, 塚本達雄, 柳田素子, 黒田知宏.
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 2 型糖尿病患者の眼底検査実施に対する影響因子の検討-高血圧、脂質異常症の併存疾患が与える影響-． (2016)
  • Author(s): 河村 太一、佐藤 泉美、田村 寛、中尾 葉子、村田 京子、川上 浩司．
  • Organizer: 第16回 日本抗加齢医学会総会．
  • Place of Presentation: パシフィコ横浜
• [Presentation] レセプト請求における未コード化傷病名削減への活動報告 (2015)
  • Author(s): 武本 基嗣, 花岡 昌数, 則本 秀美, 大野 美香子, 櫛田 奈美, 齋藤 泰司, 田村 寛, 寺前 利治.
  • Organizer: 第41回日本診療情報管理学会学術大会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2015-09-18
• [Presentation] レセプト情報・特定健診等情報（NDB）サンプリングデータセットを用いた糖尿病網膜症などへのレーザー治療の実態調査. (2015)
  • Author(s): 平木 秀輔, 田村 寛, 加藤 源太, 後藤 励, 岡本 和也, 鈴間 潔, 吉村 長久, 黒田 知宏.
  • Organizer: 第28回日本レーザー医学会関西地方会
  • Place of Presentation: TKPガーデンシティ京都
  • Year and Date: 2015-07-25
• [Presentation] 日本の糖尿病網膜症発症・進展患者における年齢構成別の薬物治療実態に関する疫学研究 (2015)
  • Author(s): 河村 太一, 村田 京子, 田村 寛, 中尾 葉子, 佐藤 泉美, 川上 浩司.
  • Organizer: 第15回日本抗加齢医学会総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2015-05-29