Establishment of quantitative measurement of retinal ischemia in eyes with central retinal vein occlusion with the use of wide-field imaging.

• Project/Area Number: 15K10841
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto University (2016-2017); Kagawa University (2015)
• Principal Investigator: Tsujilawa Akitaka 京都大学, 医学研究科, 教授 (40402846)
• Co-Investigator(Kenkyū-buntansha): 村岡 勇貴 京都大学, 医学研究科, 助教 (00739089)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 網膜中心静脈閉塞症 / 網膜

Outline of Final Research Achievements

The experimental study with a model eye elucidated that fundus images obtained with the Optos 200Tx was markedly stretched, especially in the peripheral regions. When the images were adjusted with a designed software, although the directions in the images were well corrected, the area was still significantly stretched in the peripheral regions.
Eyes with macular edema associated with acute central retinal vein occlusion were treated with intravitreal injections of anti-VEGF agents (1+PRN or 3+PRN regimen). Both regimen achieved a similarly rapid reduction in central foveal thickness, with subsequent improvement of visual acuity. Eyes with poor baseline visual acuity (<0.5) maintained improved VA for 1 year. Eyes with good baseline VA (>0.6) maintained baseline visual acuity for 1 year.

Research Products

• [Journal Article] Anti-Vascular Endothelial Growth Factor Therapy for Macular Edema following Central Retinal Vein Occlusion: 1 Initial Injection versus 3 Monthly Injections. (2018)
  • Author(s): Osaka R, Muraoka Y, Miwa Y, Manabe K, Kobayashi M, Takasago Y, Ooto S, Murakami T, Suzuma K, Iida Y, Tsujikawa A.
  • Journal Title: Ophthalmologica Volume: 239 Issue: 1 Pages: 27-35
  • DOI: 10.1159/000479049
  • Peer Reviewed
• [Journal Article] Metamorphopsia associated with central retinal vein occlusion. (2017)
  • Author(s): Manabe K, Osaka R, Nakano Y, Takasago Y, Fujita T, Shiragami C, Hirooka K, Muraoka Y, Tsujikawa A.
  • Journal Title: PLoS One. Volume: 12 Issue: 10 Pages: e0186737-e0186737
  • DOI: 10.1371/journal.pone.0186737
  • Peer Reviewed / Open Access
• [Journal Article] ASSOCIATION BETWEEN PARAFOVEAL CAPILLARY NONPERFUSION AND MACULAR FUNCTION IN EYES WITH BRANCH RETINAL VEIN OCCLUSION. (2017)
  • Author(s): Manabe S, Osaka R, Nakano Y, Takasago Y, Fujita T, Shiragami C, Hirooka K, Muraoka Y, Tsujikawa A.
  • Journal Title: Retina. Volume: 37 Issue: 8 Pages: 1731-1737
  • DOI: 10.1097/iae.0000000000001749
  • Peer Reviewed
• [Journal Article] Morphologic and Functional Retinal Vessel Changes in Branch Retinal Vein Occlusion: An Optical Coherence Tomography Angiography Study. (2017)
  • Author(s): Iida Y, Muraoka Y, Ooto S, Suzuma K, Murakami T, Iida-Miwa Y, Ghashut R, Tsujikawa A.
  • Journal Title: Am J Ophthalmol. Volume: 182 Pages: 168-179
  • DOI: 10.1016/j.ajo.2017.08.004
  • Peer Reviewed
• [Journal Article] EVALUATION OF MACULAR ISCHEMIA IN EYES WITH BRANCH RETINAL VEIN OCCLUSION: An Optical Coherence Tomography Angiography Study. (2017)
  • Author(s): Kadomoto S, Muraoka Y, Ooto S, Miwa Y, Iida Y, Suzuma K, Murakami T, Ghashut R, Tsujikawa A, Yoshimura N.
  • Journal Title: Retina Volume: 印刷中 Issue: 2 Pages: 272-282
  • DOI: 10.1097/iae.0000000000001541
  • Peer Reviewed
• [Journal Article] ASSOCIATION BETWEEN RETINAL HEMORRHAGIC PATTERNS AND PERFUSION STATUS IN EYES WITH ACUTE CENTRAL RETINAL VEIN OCCLUSION. (2017)
  • Author(s): Muraoka Y, Uji A, Tsujikawa A, Murakami T, Ooto S, Suzuma K, Takahashi A, Iida Y, Miwa Y, Hata M, Yoshimura N.
  • Journal Title: Retina Volume: 37 Issue: 3 Pages: 500-508
  • DOI: 10.1097/iae.0000000000001196
  • Peer Reviewed
• [Journal Article] Metamorphopsia Associated with Branch Retinal Vein Occlusion. (2016)
  • Author(s): Manabe K, Tsujikawa A, Osaka R, et al.
  • Journal Title: PLoS One Volume: 11 Issue: 4 Pages: e0153817-e0153817
  • DOI: 10.1371/journal.pone.0153817
  • NAID: 120005997829
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cotton wool spots after anti-vascular endothelial growth factor therapy for macular edema associated with central retinal vein occlusion. (2016)
  • Author(s): Kida T, Tsujikawa A, Muraoka Y, Harino S, Osaka R, Murakami T, Ooto S, Suzuma K, Morishita S, Fukumoto M, Suzuki H, Ikeda T.
  • Journal Title: Ophthalmologica Volume: 235 Issue: 2 Pages: 106-113
  • DOI: 10.1159/000443622
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 網膜静脈分枝閉塞症に伴う変視症 (2016)
  • Author(s): 辻川明孝
  • Organizer: 第18回Japan Macula Club.
  • Place of Presentation: 蒲郡
  • Year and Date: 2016-08-27