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Establishment of quantitative measurement of retinal ischemia in eyes with central retinal vein occlusion with the use of wide-field imaging.

Research Project

Project/Area Number 15K10841
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionKyoto University (2016-2017)
Kagawa University (2015)

Principal Investigator

Tsujilawa Akitaka  京都大学, 医学研究科, 教授 (40402846)

Co-Investigator(Kenkyū-buntansha) 村岡 勇貴  京都大学, 医学研究科, 助教 (00739089)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords網膜中心静脈閉塞症 / 網膜
Outline of Final Research Achievements

The experimental study with a model eye elucidated that fundus images obtained with the Optos 200Tx was markedly stretched, especially in the peripheral regions. When the images were adjusted with a designed software, although the directions in the images were well corrected, the area was still significantly stretched in the peripheral regions.
Eyes with macular edema associated with acute central retinal vein occlusion were treated with intravitreal injections of anti-VEGF agents (1+PRN or 3+PRN regimen). Both regimen achieved a similarly rapid reduction in central foveal thickness, with subsequent improvement of visual acuity. Eyes with poor baseline visual acuity (<0.5) maintained improved VA for 1 year. Eyes with good baseline VA (>0.6) maintained baseline visual acuity for 1 year.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Anti-Vascular Endothelial Growth Factor Therapy for Macular Edema following Central Retinal Vein Occlusion: 1 Initial Injection versus 3 Monthly Injections.2018

    • Author(s)
      Osaka R, Muraoka Y, Miwa Y, Manabe K, Kobayashi M, Takasago Y, Ooto S, Murakami T, Suzuma K, Iida Y, Tsujikawa A.
    • Journal Title

      Ophthalmologica

      Volume: 239 Issue: 1 Pages: 27-35

    • DOI

      10.1159/000479049

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metamorphopsia associated with central retinal vein occlusion.2017

    • Author(s)
      Manabe K, Osaka R, Nakano Y, Takasago Y, Fujita T, Shiragami C, Hirooka K, Muraoka Y, Tsujikawa A.
    • Journal Title

      PLoS One.

      Volume: 12 Issue: 10 Pages: e0186737-e0186737

    • DOI

      10.1371/journal.pone.0186737

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ASSOCIATION BETWEEN PARAFOVEAL CAPILLARY NONPERFUSION AND MACULAR FUNCTION IN EYES WITH BRANCH RETINAL VEIN OCCLUSION.2017

    • Author(s)
      Manabe S, Osaka R, Nakano Y, Takasago Y, Fujita T, Shiragami C, Hirooka K, Muraoka Y, Tsujikawa A.
    • Journal Title

      Retina.

      Volume: 37 Issue: 8 Pages: 1731-1737

    • DOI

      10.1097/iae.0000000000001749

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphologic and Functional Retinal Vessel Changes in Branch Retinal Vein Occlusion: An Optical Coherence Tomography Angiography Study.2017

    • Author(s)
      Iida Y, Muraoka Y, Ooto S, Suzuma K, Murakami T, Iida-Miwa Y, Ghashut R, Tsujikawa A.
    • Journal Title

      Am J Ophthalmol.

      Volume: 182 Pages: 168-179

    • DOI

      10.1016/j.ajo.2017.08.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EVALUATION OF MACULAR ISCHEMIA IN EYES WITH BRANCH RETINAL VEIN OCCLUSION: An Optical Coherence Tomography Angiography Study.2017

    • Author(s)
      Kadomoto S, Muraoka Y, Ooto S, Miwa Y, Iida Y, Suzuma K, Murakami T, Ghashut R, Tsujikawa A, Yoshimura N.
    • Journal Title

      Retina

      Volume: 印刷中 Issue: 2 Pages: 272-282

    • DOI

      10.1097/iae.0000000000001541

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASSOCIATION BETWEEN RETINAL HEMORRHAGIC PATTERNS AND PERFUSION STATUS IN EYES WITH ACUTE CENTRAL RETINAL VEIN OCCLUSION.2017

    • Author(s)
      Muraoka Y, Uji A, Tsujikawa A, Murakami T, Ooto S, Suzuma K, Takahashi A, Iida Y, Miwa Y, Hata M, Yoshimura N.
    • Journal Title

      Retina

      Volume: 37 Issue: 3 Pages: 500-508

    • DOI

      10.1097/iae.0000000000001196

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Metamorphopsia Associated with Branch Retinal Vein Occlusion.2016

    • Author(s)
      Manabe K, Tsujikawa A, Osaka R, et al.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 4 Pages: e0153817-e0153817

    • DOI

      10.1371/journal.pone.0153817

    • NAID

      120005997829

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cotton wool spots after anti-vascular endothelial growth factor therapy for macular edema associated with central retinal vein occlusion.2016

    • Author(s)
      Kida T, Tsujikawa A, Muraoka Y, Harino S, Osaka R, Murakami T, Ooto S, Suzuma K, Morishita S, Fukumoto M, Suzuki H, Ikeda T.
    • Journal Title

      Ophthalmologica

      Volume: 235 Issue: 2 Pages: 106-113

    • DOI

      10.1159/000443622

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 網膜静脈分枝閉塞症に伴う変視症2016

    • Author(s)
      辻川明孝
    • Organizer
      第18回Japan Macula Club.
    • Place of Presentation
      蒲郡
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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