Effects of Visual Acuity on QOL in Elderly and Investigation of Pathology on Age-Related Macular Degeneration
| Project/Area Number |
15K10843
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nara Medical University |
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Principal Investigator |
Ogata Nahoko 奈良県立医科大学, 医学部, 教授 (60204062)
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| Co-Investigator(Kenkyū-buntansha) |
上田 哲生 奈良県立医科大学, 医学部, 准教授 (00364068)
車谷 典男 奈良県立医科大学, 医学部, 副学長 (10124877)
山下 真理子 奈良県立医科大学, 医学部附属病院, 研究員 (10645659)
西 智 奈良県立医科大学, 医学部, 講師 (70571214)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 加齢黄斑変性 / 白内障 / 白内障手術 / 認知症 / 概日リズム / 高齢者 / QOL / 視力 / 疫学研究 / 認知機能 |
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| Outline of Final Research Achievements |
The elderly （2826 subjects) who participated Fujiwara-kyo Eye Study presented the association between the visual acuity and gait speed/standing time of on one leg. Of those, the subjects who had prior cataract surgery (24.2%) had significantly lower odds ratio of having mild cognitive impairment than those who had not had cataract surgery.
The plasma levels of von Willebrand factor antigen (VWF Ag) in patients with exudative age-related macular degeneration (AMD) were significantly higher than those in controls. Thus, VWF may play an important role in the pathophysiology of AMD.
In vitro study, advanced glycation endproduct (AGE), hydroquinone (HQ), and amyloid β effected on VEGF-A expression of human retinal pigment epithelial (RPE) cells. These results indicated that those factors also play an important role in the pathophysiology of AMD.
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| Academic Significance and Societal Importance of the Research Achievements |
高齢者が健康を維持しQuality of Life (QOL)を保つには視機能が重要であり、視機能が低下すると運動能力も低下することが明らかになった。認知症が大きな社会問題となっている現在、白内障手術によって視機能が改善するだけでなく、軽度認知機能障害のリスクが有意に低下することが明らかになった。さらに加齢黄斑変性患者が急増しているが、その病態、誘因について全身な面からin vivo、in vitroで明らかにすることができた。
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Report
(5 results)
Research Products
(93 results)
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[Journal Article] The effect of blue-blocking intraocular lenses on circadian biological rhythm: protocol for a randomised controlled trial (CLOCK-IOL colour study).2015
Author(s)
Nishi T, Saeki K, Obayashi K, Miyata K, Tone N, Tsujinaka H, Yamashita M, Masuda N, Mizusawa Y, Okamoto M, Hasegawa T, Maruoka S, Ueda T, Kojima M, Matsuura T, Kurumatani N, Ogata N.
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Journal Title
BMJ Open
Volume: 5
Issue: 5
Pages: e007930-e007930
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Glaucoma, Melatonin Secretion, and Depressive Symptoms:Cross-Sectional Findings from the HEIJO-KYO Cohort2016
Author(s)
Miyata K, Obayashi K, Saeki K, Nishi T, Kurumatani N, Ogata N
Organizer
SLEEP 2016, the 30th Anniversary Meeting of the APSS
Place of Presentation
Denver, Colorado , USA
Year and Date
2016-06-11
Related Report
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[Presentation] Human Retinal Pigment Epithelial Cell Proliferation by the Combined Addition of Hydroquinone and Advanced Glycation End-products Via Up-regulation of VEGFgene2016
Author(s)
Tsujinaka H, Itaya-Hironakaa A Yamauchi A, Sakuramoto-Tsuchida S, Fujimura T, Shobatake R, Yoshikawa T, Masuda N, Ohtsuki M, Takasawa S, Ogata N
Organizer
The Association for Research in Vision and Ophthalmology 2016
Place of Presentation
Seattle,Washington , USA
Year and Date
2016-05-01
Related Report
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[Presentation] Cataract surgery,objective sleep quality,and cognition in the general elderly population:a cross-sectional study of the heijo-kyo cohort2015
Author(s)
Kimie Miyata, Kenji Obayashi, Keigo Saeki, Noburiro Tone, Tomo Nishi, Norio Kurumatani, Nahoko Ogata
Organizer
SLEEP 2015
Place of Presentation
Seattle, Washington, USA
Year and Date
2015-06-11
Related Report
Int'l Joint Research
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[Presentation] Combined stimulation of IL-6 and dexamethasone activated human REG Iα and REG Iβgene transcription in humanpancreatic β cells via the JAK/STAT signaling pathway2015
Author(s)
Akiyo Yamauchi, Asako Itaya-Hironaka, Sumiyo Sakuramoto-Tsuchida, Maiko Takeda, Kiyomi Yoshimoto, Tomoko Miyaoka, Takanori Fujimura, Hiroki Tsujinaka, Chikatsugu Tsuchida, Hiroyo Ota, Shin Takasawa
Organizer
75th American Diabetes Association Scientific Sessions
Place of Presentation
Boston, Massachusetts, USA
Year and Date
2015-06-05
Related Report
Int'l Joint Research
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[Presentation] Visual Acuity and the Prevalence of Fundus Diseases in Japanese Elderly: Baseline Data of the Fujiwara-Kyo Cohort Study2015
Author(s)
Kimie Miyata, Tomo Nishi, Taiji Hasegawa, Takeshi Kobayasi, Masahiro Okamoto, Masashi Mine, Tetsuo Ueda, Toyoaki Matsuura, Nozomi Okamoto, Norio Kurumatani, and Nahoko Ogata
Organizer
The Association for Research in Vision and Ophthalmology 2015
Place of Presentation
Denver,Colorado , USA
Year and Date
2015-05-04
Related Report
Int'l Joint Research
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