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Development of basic methods to study retinal microvascular abnormalities by using optical coherence tomography angiography

Research Project

Project/Area Number 15K10845
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionSaitama Medical University

Principal Investigator

Hangai Masanori  埼玉医科大学, 医学部, 客員教授 (70283687)

Co-Investigator(Kenkyū-buntansha) 庄司 拓平  埼玉医科大学, 医学部, 講師 (70637058)
Research Collaborator YASUHIRO Furuuchi  (株)ニデック, アイケア事業部 開発本部, 研究員
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords光干渉断層計アンギオグラフィー / 網膜 / 視神経乳頭 / 微小循環障害 / 毛細血管 / 緑内障 / 微小循環 / 網膜微小循環障害 / 視神経乳頭微小循環障害 / 眼底毛細血管 / 緑内障性微小循環障害
Outline of Final Research Achievements

Microvascular abnormalities are implicated in various retinal diseases, such as diabetic retinopathy and retinal vein occlusive diseases, and glaucoma. However, there had been no methods that allow us to visualize three-dimensional vascular structure of the retina and optic nerve head in patients. It is known that the microvascular systems of the retina and optic nerve head consist of 4 and 3 capillary layers, respectively. In this study, we have developed methods to analyze each of the capillary layers by using optical coherence tomography angiography technology. These methods enabled us to see in which capillary layer vascular pathological lesions, such as microaneurysms and nonperfusion areas, are present in each patient eye at each his visit. We believe the current results will open new avenues to non-invasively study pathological mechanisms in retinal and glaucoma patients.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Invited: 4 results) Book (2 results)

  • [Journal Article] Optic disc vessel density in non-glaucomatous and glaucomatous eyes: an enhanced-depth imaging optical coherence tomography angiography study2018

    • Author(s)
      Yuji Yoshikawa, Takuhei Shoji, Junji Kanno, Itaru Kimura, Masanori Hangai, Kei Shinoda
    • Journal Title

      Clinical Ophthalmology

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Analysis of the structural changes of laminar capillaries in glaucoma using OCT angiography2017

    • Author(s)
      Yoshikawa Y, Hangai M, Shouji T, Kanno J, Uji A, Hanebuchi M, Furuuchi Y.
    • Organizer
      欧州眼科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糖尿病黄斑浮腫の画像診断と治療2017

    • Author(s)
      板谷正紀
    • Organizer
      日本眼科手術学会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 緑内障のOCT(仮題)2016

    • Author(s)
      板谷正紀
    • Organizer
      第70回臨床眼科学会
    • Place of Presentation
      京都国際議場(京都府京都市)
    • Year and Date
      2016-11-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 光干渉断層計アンギオグラフィーを用いた緑内障における篩状板血管構造変化の解析2016

    • Author(s)
      吉川祐司、板谷正紀、庄司拓平、管野順二、宇治彰人
    • Organizer
      日本緑内障学会
    • Place of Presentation
      横浜
    • Related Report
      2016 Research-status Report
  • [Presentation] 緑内障におけるOCTのインパクト2016

    • Author(s)
      板谷正紀
    • Organizer
      日本臨床眼科学会
    • Place of Presentation
      京都
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 後眼部OCTの今2015

    • Author(s)
      板谷正紀
    • Organizer
      第69回臨床眼科学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-25
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 光干渉断層計アンギオグラフィーによる網膜毛細血管網4層分離描出法の確立2015

    • Author(s)
      板谷正紀
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      ロイトン札幌エンプレイスホール(北海道札幌市)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
  • [Book] Spectral Domain Optical Coherence Tomography in Macular Diseases2016

    • Author(s)
      Carsten H. Meyer and Sandeep Saxena
    • Total Pages
      251
    • Publisher
      Springer
    • Related Report
      2016 Research-status Report
  • [Book] Spectral-domain Optical Coherence Tomography in Macular Diseases2016

    • Author(s)
      Masanori Hangai(分担執筆)
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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