Postoperative inflammation of ocular surgery in patients with diabetetes mellitus

• Project/Area Number: 15K10849
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Tokyo Medical University
• Principal Investigator: Yasuda Kanako 東京医科大学, 医学部, 講師 (70647461)
• Co-Investigator(Kenkyū-buntansha): 志村 雅彦 東京医科大学, 医学部, 教授 (20302135) ; 野間 英孝 東京医科大学, 医学部, 准教授 (80304442)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 糖尿病網膜症 / 術後炎症 / レーザーフレアセル / 硝子体手術 / 白内障手術 / 糖尿病 / 前房フレア / 重症糖尿病 / サイトカイン / 黄斑浮腫

Outline of Final Research Achievements

In case of cataract and/or vitreoretinal surgery in patients with diabetes, careful observation during perioperative period should be required due to their general condition of chronic inflammation. In our study, dynamic chages of post operative inflammtion after cataract/vitreoretinal surgery were disclosed. Compared to non-diabetic patients, even before the surgery, ocular inflammation evaluated by laser flare cell score showed higher value. In addition, postoperative inflammation showed higher and longer status in eyes with daiabetic patients. Interestingly, higher (10 times more) and longer(3 times more ) postoperative inflammation in diabetic eyes were significantly correlated to both longer operation time and more

Research Products

• [Journal Article] Comparative effects of topical diclofenac and metamethasone on inflammation after vitrectomy and cataract surgery in various vitreoretinal disease (2016)
  • Author(s): 32.Yasuda, K., Motohashi, R., Kotake, O., Nakagawa, H., Noma, H. and Shimura, M.
  • Journal Title: Journal of Ocular Pharmacology and Therapeutics Volume: 32 Pages: 677-684
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 無縫合硝子体手術後の術後眼圧変動についての検討 (2018)
  • Author(s): 内海卓也、安田佳奈子、志村雅彦
  • Organizer: 2018年日本眼科学会総会
• [Presentation] Role of Soluble Vascular Endothelial Growth Factor Receptor Signaling and Other (2016)
  • Author(s): Noma H, Yasuda K, Shimura M
  • Organizer: 2016 Annual Meeting of Association for Research in Vision and Ophthalmology
  • Place of Presentation: Seatle
  • Year and Date: 2016-05-01
  • Int'l Joint Research