| Project/Area Number |
15K10849
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
Yasuda Kanako 東京医科大学, 医学部, 講師 (70647461)
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| Co-Investigator(Kenkyū-buntansha) |
志村 雅彦 東京医科大学, 医学部, 教授 (20302135)
野間 英孝 東京医科大学, 医学部, 准教授 (80304442)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 糖尿病網膜症 / 術後炎症 / レーザーフレアセル / 硝子体手術 / 白内障手術 / 糖尿病 / 前房フレア / 重症糖尿病 / サイトカイン / 黄斑浮腫 |
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| Outline of Final Research Achievements |
In case of cataract and/or vitreoretinal surgery in patients with diabetes, careful observation during perioperative period should be required due to their general condition of chronic inflammation. In our study, dynamic chages of post operative inflammtion after cataract/vitreoretinal surgery were disclosed. Compared to non-diabetic patients, even before the surgery, ocular inflammation evaluated by laser flare cell score showed higher value. In addition, postoperative inflammation showed higher and longer status in eyes with daiabetic patients. Interestingly, higher (10 times more) and longer(3 times more ) postoperative inflammation in diabetic eyes were significantly correlated to both longer operation time and more
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