Tailor-made medicine of age-related macular degeneration using fluorescence of verteporfin

• Project/Area Number: 15K10850
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Iida Tomohiro 東京女子医科大学, 医学部, 教授 (50241881)
• Co-Investigator(Kenkyū-buntansha): 丸子 一朗 東京女子医科大学, 医学部, 特任講師 (10443871) ; 古泉 英貴 琉球大学, 医学(系)研究科(研究院), 教授 (20551500)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ベルテポルフィン / 光線力学的療法 / 滲出型加齢黄斑変性 / 蛍光撮影 / 脈絡膜新生血管 / マウス

Outline of Final Research Achievements

Photodynamic therapy using verteporfin is an effective treatment for eyes with exudative age-related macular degeneration. To constract the tailor-made medicine of age-related macular degeneration, we examined fluorescence of verteporfin in vivo. Using fundus camera, we found fluorescence of verteporfin in retinal vessels and experimental choroidal neovascularization in rat eyes. However, we did not find fluorescence of verteporfin using fundus camera in eye with exudative age-related macular degeneration.

Research Products

• [Journal Article] Unmeasurable small size of foveal avascular zone without visual impairment in optical coherence tomography angiography. (2018)
  • Author(s): Yokoyama T, Maruko I, Koizumi H, Ishikawa Y, Iida T
  • Journal Title: Eye (Lond) Volume: 印刷中 Issue: 6 Pages: 1062-1066
  • DOI: 10.1038/s41433-017-0005-z
  • Peer Reviewed
• [Journal Article] MACULAR HOLE FORMATION IDENTIFIED WITH INTRAOPERATIVE OCT DURING VITRECTOMY FOR VITREOMACULAR TRACTION SYNDROME (2017)
  • Author(s): Sawaguchi Shota、Maruko Ichiro、Mikami Yuriko、Hasegawa Taiji、Koizumi Hideki、Iida Tomohiro
  • Journal Title: Retinal Cases & Brief Reports Volume: 印刷中 Issue: 4 Pages: 380-382
  • DOI: 10.1097/icb.0000000000000377
  • Peer Reviewed / Open Access
• [Journal Article] Subthreshold 577 nm micropulse laser treatment for central serous chorioretinopathy (2017)
  • Author(s): Maruko Ichiro、Koizumi Hideki、Hasegawa Taiji、Arakawa Hisaya、Iida Tomohiro
  • Journal Title: PLOS ONE Volume: 12 Issue: 8 Pages: e0184112-e0184112
  • DOI: 10.1371/journal.pone.0184112
  • Peer Reviewed / Open Access
• [Journal Article] Structural Analyses of Choroid after Half-Dose Verteporfin Photodynamic Therapy for Central Serous Chorioretinopathy (2017)
  • Author(s): Izumi T, Koizumi H, Maruko I, Takahashi Y, Sonoda S, Sakamoto T, Iida T
  • Journal Title: Br J Ophthalmol Volume: 101 Issue: 4 Pages: 433-437
  • DOI: 10.1136/bjophthalmol-2016-308921
  • Peer Reviewed
• [Journal Article] Optical Coherence Tomographic Predictor of Retinal Non-Perfused Areas in Eyes with Macular Oedema Associated With Retinal Vein Occlusion (2016)
  • Author(s): Hasegawa T, Yamashita M, Maruko I, Koizumi H, Kogure A, Ogata N, Iida T.
  • Journal Title: Br J Ophthalmol Volume: Epub ahead of print Issue: 5 Pages: 569-573
  • DOI: 10.1136/bjophthalmol-2016-308813
  • Peer Reviewed
• [Journal Article] Two-year results of combined intravitreal ranibizumab and photodynamic therapy for retinal angiomatous proliferation (2016)
  • Author(s): Saito M, Iida T, Kano M, Itagaki K
  • Journal Title: Jpn J Ophthalmol Volume: 60 Pages: 42-50
  • NAID: 210000185382
  • Peer Reviewed
• [Journal Article] Age-Dependent Morphologic Alterations in the Outer Retinal and Choroidal Thicknesses Using Swept Source Optical Coherence Tomography (2016)
  • Author(s): Maruko I, Arakawa H, Koizumi H, Izumi R, Sunagawa H, Iida T
  • Journal Title: PLoS One Volume: 11 Issue: 7 Pages: e0159439-e0159439
  • DOI: 10.1371/journal.pone.0159439
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Subfoveal Choroidal Thickness During Aflibercept Therapy for Neovascular Age-related Macular Degeneration: 12-Month Results (2016)
  • Author(s): Koizumi H, Kano M, Yamamoto A, Saito M, Maruko I, Sekiryu T, Okada AA, Iida T
  • Journal Title: Ophthalmology Volume: 123 Issue: 3 Pages: 617-624
  • DOI: 10.1016/j.ophtha.2015.10.039
  • Peer Reviewed
• [Journal Article] Relative changes in luminal and stromal areas of choroid determined by binarization of EDI-OCT images in eyes with Vogt-Koyanagi-Harada disease after treatment (2016)
  • Author(s): Kawano H, Sonoda S, Yamashita T, Maruko I, Iida T, Sakamoto T
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 254 Issue: 3 Pages: 421-426
  • DOI: 10.1007/s00417-016-3283-4
  • Peer Reviewed / Open Access
• [Journal Article] Aflibercept therapy for polypoidal choroidal vasculopathy: short-term results of a multicentre study. (2015)
  • Author(s): Koizumi H, et al.
  • Journal Title: British Journal of Ophthalmology Volume: 未定 Issue: 9 Pages: 1284-1288
  • DOI: 10.1136/bjophthalmol-2014-306432
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] One-Year Results of Intravitreal Aflibercept for Polypoidal Choroidal Vasculopathy (2015)
  • Author(s): Yamamoto A, Okada AA, Kano M, Koizumi H, Saito M, Maruko I, Sekiryu T, Iida T
  • Journal Title: Ophthalmology Volume: 122 Issue: 9 Pages: 1866-1872
  • DOI: 10.1016/j.ophtha.2015.05.024
  • Peer Reviewed
• [Journal Article] MMP20 and ARMS2/HTRA1 are Associated with Neovascular Lesion Size in Age-Related Macular Degeneration (2015)
  • Author(s): Akagi-Kurashige Y, Yamashiro K, Gotoh N, Miyake M, Morooka S, Yoshikawa M, Nakata I, Kumagai K, Tsujikawa A, Yamada R, Matsuda F, Saito M, Iida T, Sugahara M, Kurimoto Y, Cheng CY, Khor CC, Wong TY, Yoshimura N; Nagahama Cohort Research Group
  • Journal Title: Ophthalmology Volume: 122 Issue: 11 Pages: 2295-2302
  • DOI: 10.1016/j.ophtha.2015.07.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Macular detachment associated with intrachoroidal cavitation in nonpathological myopic eyes (2015)
  • Author(s): Ando Y, Inoue M, Ohno-Matsui K, Kusumi Y, Iida T, Hirakata A.
  • Journal Title: Retina Volume: 35 Issue: 10 Pages: 1943-1950
  • DOI: 10.1097/iae.0000000000000575
  • Peer Reviewed
• [Journal Article] Spontaneous remission of acute zonal occult outer retinopathy: follow-up using adaptive optics scanning laser ophthalmoscopy (2015)
  • Author(s): Nakao S, Kaizu Y, Yoshida S, Iida T, Ishibashi T
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 253 Issue: 6 Pages: 839-843
  • DOI: 10.1007/s00417-014-2760-x
  • Peer Reviewed
• [Journal Article] Subfoveal choroidal thickness changes after intravitreal ranibizumab and photodynamic therapy for retinal angiomatous proliferation (2015)
  • Author(s): Maruko I, Iida T, Oyamada H, Sugano Y, Saito M, Sekiryu T
  • Journal Title: Retina Volume: 35 Issue: 4 Pages: 648-654
  • DOI: 10.1097/iae.0000000000000486
  • Peer Reviewed
• [Journal Article] Short-term changes in choroidal thickness after aflibercept therapy for neovascular age-related macular degeneration. (2014)
  • Author(s): Koizumi H, Kano M, Yamamoto A, Saito M, Maruko I, Kawasaki R, Sekiryu T, Okada AA, Iida T.
  • Journal Title: Am J Ophthalmol. Volume: 159 Issue: 4 Pages: 627-633
  • DOI: 10.1016/j.ajo.2014.12.025
  • Peer Reviewed