Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Outline of Final Research Achievements |
Recently, the roles of endogenous substance polyamines and its metabolizing enzymes have been focused on in the pathogenesis of systemic diseases such as diabetes. In the current study, we investigated the production mechanism of polyamine-metabolizing enzymes under diabetic condition. Hypoxia induces the production of spermine oxidase (SMOX), and subsequently increases the generation of hydrogen peroxide and acrolein, oxidative stress inducer and unsaturated aldehyde, respectively, through the metabolic reaction of spermine by SMOX in cultured retinal glial cells. The current data indicate that SMOX plays a role in the oxidative stress increase exacerbated under hypoxic condition in diabetic retinopathy.
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