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Polyamine metabolism in diabetic retinopathy

Research Project

Project/Area Number 15K10855
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionHokkaido University

Principal Investigator

Noda Kousuke  北海道大学, 医学研究院, 准教授 (90296666)

Co-Investigator(Kenkyū-buntansha) 神田 敦宏  北海道大学, 医学研究院, 特任講師 (80342707)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords糖尿病網膜症 / ポリアミン / 酸化ストレス / 眼細胞生物学
Outline of Final Research Achievements

Recently, the roles of endogenous substance polyamines and its metabolizing enzymes have been focused on in the pathogenesis of systemic diseases such as diabetes. In the current study, we investigated the production mechanism of polyamine-metabolizing enzymes under diabetic condition. Hypoxia induces the production of spermine oxidase (SMOX), and subsequently increases the generation of hydrogen peroxide and acrolein, oxidative stress inducer and unsaturated aldehyde, respectively, through the metabolic reaction of spermine by SMOX in cultured retinal glial cells. The current data indicate that SMOX plays a role in the oxidative stress increase exacerbated under hypoxic condition in diabetic retinopathy.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(32 results)

All 2018 2017 2016 2015

All Journal Article (19 results) (of which Peer Reviewed: 11 results,  Open Access: 6 results) Presentation (11 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Book (2 results)

  • [Journal Article] Proteolytic cleavage of vascular adhesion protein-1 induced by vascular endothelial growth factor in retinal capillary endothelial cells2018

    • Author(s)
      Yoshida Shiho、Murata Miyuki、Noda Kousuke、Matsuda Takashi、Saito Michiyuki、Saito Wataru、Kanda Atsuhiro、Ishida Susumu
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 62 Issue: 2 Pages: 256-264

    • DOI

      10.1007/s10384-017-0555-4

    • ISSN
      0021-5155, 1613-2246
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Localization of Acrolein-Lysine Adduct in Fibrovascular Tissues of Proliferative Diabetic Retinopathy2017

    • Author(s)
      Dong Yoko、Noda Kousuke、Murata Miyuki、Yoshida Shiho、Saito Wataru、Kanda Atsuhiro、Ishida Susumu
    • Journal Title

      Curr Eye Res.

      Volume: 42 Pages: 111-117

    • DOI

      10.3109/02713683.2016.1150491

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular Adhesion Protein-1 Blockade Suppresses Ocular Inflammation After Retinal Laser Photocoagulation in Mice2017

    • Author(s)
      Matsuda Takashi、Noda Kousuke、Murata Miyuki、Kawasaki Akiko、Kanda Atsuhiro、Mashima Yukihiko、Ishida Susumu
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 58 Pages: 3254-3261

    • DOI

      10.1167/iovs.17-21555

    • NAID

      120006337769

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Soluble Vascular Adhesion Protein-1 Mediates Spermine Oxidation as Semicarbazide-Sensitive Amine Oxidase: Possible Role in Proliferative Diabetic Retinopathy2017

    • Author(s)
      Murata Miyuki、Noda Kousuke、Kawasaki Akiko、Yoshida Shiho、Dong Yoko、Saito Michiyuki、Dong Zhenyu、Ando Ryo、Mori Shohei、Saito Wataru、Kanda Atsuhiro、Ishida Susumu
    • Journal Title

      Curr Eye Res.

      Volume: 42 Pages: 1674-1683

    • DOI

      10.1080/02713683.2017.1359847

    • NAID

      120006540056

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 糖尿病黄斑浮腫に対するメディカルアプローチに関する最近の話題2017

    • Author(s)
      野田航介
    • Journal Title

      あたらしい眼科

      Volume: 34 Pages: 639-644

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 糖尿病合併症動物モデルの探索. Young Investigator Award受賞講演.2017

    • Author(s)
      野田航介
    • Journal Title

      糖尿病合併症

      Volume: 31 Pages: 135-141

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitreous levels of vascular endothelial growth factor-B in proliferative diabetic retinopathy2016

    • Author(s)
      Kinoshita S, Noda K, Saito W, Kanda A, Ishida S
    • Journal Title

      Acta Ophthalmol

      Volume: -

    • DOI

      10.1111/aos.12969

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 糖尿病網膜症. 特集眼疾患の治療2016

    • Author(s)
      野田航介、石田 晋
    • Journal Title

      医学と薬学

      Volume: 73 Pages: 1135-1142

    • Related Report
      2016 Research-status Report
  • [Journal Article] Localization of Acrolein-lysine adduct in fibrovascular tissues of proliferative diabetic retinopathy2016

    • Author(s)
      Dong Y, Noda K, Murata M, Yoshida S, Saito W, Kanda A, Ishida S
    • Journal Title

      Curr Eye Res

      Volume: -

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Occult hypertensive choroidopathy: novel finding of suprachoroidal fluid2016

    • Author(s)
      Saito W, Saito M, Hashimoto Y, Ishida S
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: -

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in inner and outer retinal layer thicknesses after vitrectomy for idiopathic macular hole: Implications for visual prognosis2015

    • Author(s)
      Hashimoto Y, Saito W, Fujiya A, Yoshizawa C, Hirooka K, Mori S, Noda K, Ishida S
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0135925

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aflibercept traps galectin-1, an angiogenic factor associated with diabetic retinopathy.2015

    • Author(s)
      Kanda A, Noda K, Saito W, Ishida S
    • Journal Title

      Sci Rep

      Volume: 5 Pages: 17946-17946

    • DOI

      10.1038/srep17946

    • NAID

      120005690890

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 糖尿病網膜症・黄斑浮腫の分子病態(総説)2015

    • Author(s)
      安藤 亮、野田航介
    • Journal Title

      あたらしい眼科

      Volume: 32 Pages: 327-330

    • Related Report
      2015 Research-status Report
  • [Journal Article] 抗VEGF薬の基礎研究と開発の歴史2015

    • Author(s)
      野田航介
    • Journal Title

      あたらしい眼科

      Volume: 32 Pages: 1069-1073

    • Related Report
      2015 Research-status Report
  • [Journal Article] 知っておきたい糖尿病網膜症 (DR) の2大病態. 合併症 網膜症(総説)2015

    • Author(s)
      野田航介
    • Journal Title

      プラクティス

      Volume: 32 Pages: 13-15

    • Related Report
      2015 Research-status Report
  • [Journal Article] 近年における糖尿病網膜症 (DR) 診療機器の進歩. 合併症 網膜症(総説)2015

    • Author(s)
      野田航介
    • Journal Title

      プラクティス

      Volume: 32 Pages: 132-135

    • Related Report
      2015 Research-status Report
  • [Journal Article] 糖尿病網膜症 (DR) に対する分子標的治療 - 抗VEGF療法. 合併症 網膜症(総説)2015

    • Author(s)
      野田航介
    • Journal Title

      プラクティス

      Volume: 32 Pages: 260-262

    • Related Report
      2015 Research-status Report
  • [Journal Article] 糖尿病網膜症と基礎研究2015

    • Author(s)
      野田航介
    • Journal Title

      月刊糖尿病

      Volume: 7 Pages: 14-18

    • Related Report
      2015 Research-status Report
  • [Journal Article] VAP-1の糖尿病網膜症における基礎研究(総説)2015

    • Author(s)
      眞島行彦、野田航介
    • Journal Title

      別冊Bio Clinica「慢性炎症と疾患」

      Volume: 4 Pages: 131-137

    • Related Report
      2015 Research-status Report
  • [Presentation] Accumulation of acrolein-conjugated protein in the vitreous fluid of proliferative diabetic retinopathy2017

    • Author(s)
      Noda K, Murata M, Saito W, Kanda A, Ishida S.
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modulation of spermine oxidation in Muller glial cells under hypoxic condition2017

    • Author(s)
      Wu D, Noda K, Murata M, Liu Y, Kanda A, Ishida S.
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 網膜グリア細胞に対するアクロレインの作用2017

    • Author(s)
      野田航介、村田美幸、吉田志帆、神田敦宏、石田 晋
    • Organizer
      第32回日本糖尿病合併症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糖尿病網膜症に対する創薬研究. 評議員会指名講演 「眼科のトランスレーショナルリサーチ」2017

    • Author(s)
      野田航介
    • Organizer
      第121回日本眼科学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Hypoxiainduces hydrogen peroxide generation via spermine oxidase in glial cells2017

    • Author(s)
      Wu D, Noda K, Murata M, Liu Y, Kanda A, Ishida S.
    • Organizer
      第121回日本眼科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糖尿病黄斑浮腫治療における抗VEGF療法の最近の動向. シンポジウム「バージョンアップ網膜症-病態・診断・治療」2017

    • Author(s)
      野田航介
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] VEGF阻害薬と次の分子標的. シンポジウム「硝子体内注射の現況と進展」2017

    • Author(s)
      野田航介
    • Organizer
      第37回日本眼薬理学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 増殖糖尿病網膜症患者の硝子体アクロレイン結合蛋白FDP-lysine濃度2016

    • Author(s)
      森 祥平、村田美幸、野田航介、鈴木智浩、齋藤理幸、安藤 亮、加瀬 諭、齋藤 航、神田敦宏、石田 晋
    • Organizer
      第55回日本網膜硝子体学会総会
    • Place of Presentation
      ベルサール渋谷ガーデン(東京都渋谷区)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 糖尿病網膜症におけるポリアミン代謝の病態関与2016

    • Author(s)
      野田航介、村田美幸、神田敦宏、石田 晋
    • Organizer
      第22回日本糖尿病眼学会総会
    • Place of Presentation
      仙台国際センター(仙台市青葉区)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Accumulation of acrolein-lys adduct in the vitreous fluid of proliferative diabetic retinopathy2016

    • Author(s)
      Noda K, Murata M, Kanda A, Ishida S
    • Organizer
      49th Annual Retina Society Meeting
    • Place of Presentation
      The U.S. Grant Hotel(San Diego, USA)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Polyamine oxidation in diabetic retinopathy2016

    • Author(s)
      Noda K
    • Organizer
      11th Japan-Korea International Symposium in Ophthalmology
    • Place of Presentation
      Hokkaido University(Sapporo, Japan)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] Monthly Book OCULISTA 482017

    • Author(s)
      野田航介
    • Total Pages
      150
    • Publisher
      全日本病院出版会
    • Related Report
      2016 Research-status Report
  • [Book] 知っているようで知らない新しい糖尿病網膜症診療2016

    • Author(s)
      野田航介
    • Total Pages
      268
    • Publisher
      メジカルビュー社
    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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