Development of photodynamic therapy on age-related macular degeneration based on abnormally-aggregated proteins.
| Project/Area Number |
15K10859
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KAJI YUICHI 筑波大学, 医学医療系, 准教授 (50361332)
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| Research Collaborator |
KANO Hideaki 筑波大学, 数理物質系, 准教授 (70334240)
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| Project Period (FY) |
2015-10-21 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 加齢黄斑変性 / アミロイドβ / 蛋白糖化最終産物 / 右手型アミノ酸 / 光線力学療法 / 光感受性物質 / 加齢黄斑変性症 / ドルーゼン / 異常凝集蛋白 / D-アミノ酸 / 自己抗体 / 糖尿病網膜症 / 抗酸化物質 / アミロイド / 血管新生 / 抗加齢医学 |
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| Outline of Final Research Achievements |
Abnormally aggregated proteins including amyloid-b is detected in age-related macular degeneration. We found increased concentration of autoantibodies to racemized or advanced glycated amyloid-b. Racemaized and advanced glycated amyloid-b peptide showed increased aggregation to form oligomer or polymer in vitro. Using thioflavin-T as photosensitized reagent, we successfully destroy aggregated form of amyloid-b. These results have become a molecular basis of photodynamic therapy on age-related macular degeneration.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] SHG-specificity of cellular Rootletin filaments enables naive imaging with universal conservation2017
Author(s)
Toshihiro Akiyama, Akihito Inoko, Yuichi Kaji, Shigenobu Yonemura, Kisa Kakiguchi, Hiroki Segawa, Kei Ishitsuka, Masaki Yoshida, Osamu Numata, Philippe Leproux, Vincent Couderc, Tetsuro Oshika, Hideaki Kano
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 39967-39967
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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