Investigation of the onset mechanism of primary open-angle glaucoma -Genetic investigation of the mechanism of intraocular pressure elevation-
Project/Area Number |
15K10861
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | University of Yamanashi |
Principal Investigator |
MABUCHI Fumihiko 山梨大学, 大学院総合研究部, 医学研究員 (20322125)
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Co-Investigator(Kenkyū-buntansha) |
柏木 賢治 山梨大学, 大学院総合研究部, 准教授 (30194723)
櫻田 庸一 山梨大学, 大学院総合研究部, 講師 (90456476)
米山 征吾 山梨大学, 大学院総合研究部, 助教 (90751652)
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Research Collaborator |
KUWABARA Ryoko
YOSHIZAWA Satoko
MABUCHI Nakako
KUME Atsuki
IIJIMA Hiroyuki
YAMAGATA Zentaro
TAKMOTO Mitsuko
AIHARA Makoto
IWATA Takeshi
SHIGA Yukihiro
NISHIGUCHI Koji
NAKAZAWA Toru
KAWASE Kazuhike
OZAKI Mineo
ARAIE Makoto
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 原発開放隅角緑内障 / 遺伝子多型 / 眼圧 / POAG / IOP / NTG / HTG / VCDR |
Outline of Final Research Achievements |
This study was performed to investigate the association between the additive effects of intraocular presure (IOP)-related genetic variants and maximum IOP, vertical cup-to-disc ratio (VCDR), and high tension glaucoma (HTG) or normal tension glaucoma (NTG) as phenotypic features of POAG. As the total number of risk alleles of IOP-related genetic variants increased, the maximum IOP and VCDR significantly increased. The IOP and VCDR were increased by the additive effects of IOP-related genetic variants in POAG, and the phenotype (HTG or NTG) in POAG depends on the additive effects of IOP-related genetic variants.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Additive effects of genetic variants associated with intraocular pressure in primary open-angle glaucoma.2017
Author(s)
Mabuchi F, Mabuchi N, Sakurada Y, Yoneyama S, Kashiwagi K, Iijima H, Yamagata Z, Takamoto M, Aihara M, Iwata T, Kawase K, Shiga Y, Nishiguchi KM, Nakazawa T, Ozaki M, Araie M; Japan Glaucoma Society Omics Group (JGS-OG).
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Journal Title
PLoS One.
Volume: 12(8)
Issue: 8
Pages: e0183709-e0183709
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genetic Variant Near PLXDC2 Influences the Risk of Primary Open-angle Glaucoma by Increasing Intraocular Pressure in the Japanese Population.2017
Author(s)
Mabuchi F, Mabuchi N, Takamoto M, Sakurada Y, Yoneyama S, Kashiwagi K, Iijima H, Yamagata Z, Aihara M, Iwata T, Araie M. Japan Glaucoma Society Omics Group (JGS-OG).
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Journal Title
J Glaucoma
Volume: 26(11)
Issue: 11
Pages: 963-966
DOI
Related Report
Peer Reviewed
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[Presentation] Additive effects of genetic variants associated with intraocular pressure in primary open-angle glaucoma2017
Author(s)
Fumihiko Mabuchi, Nakako Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Hiroyuki Iijima, Zentaro Yamagata, Mitsuko Takamoto, Makoto Aihara, Takeshi Iwata, Kazuhide Kawase, Yukihiro Shiga, Koji Nishiguchi, Toru Nakazawa, Mineo Ozaki, Makoto Araie, Japan Glaucoma Society Omics Group (JGS-OG)
Organizer
7th World Glaucoma Congress (WGC)
Related Report
Int'l Joint Research
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[Presentation] Additive effects of genetic variants associated with primary open-angle glaucoma2017
Author(s)
Fumihiko Mabuchi, Nakako Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Hiroyuki Iijima, Zentaro Yamagata, Mitsuko Takamoto, Makoto Aihara, Takeshi Iwata, Kazuhide Kawase, Yukihiro Shiga, Koji Nishiguchi, Toru Nakazawa, Mineo Ozaki, Makoto Araie, Japan Glaucoma Society Omics Group (JGS-OG)
Organizer
American Society of Human Genetics (ASHG)
Related Report
Int'l Joint Research
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[Presentation] 眼圧上昇に関与する遺伝子多型と眼圧の関連について2016
Author(s)
間渕文彦, 間渕央子, 櫻田庸一, 米山征吾, 柏木賢治, 山縣然太朗, 飯島裕幸, 日本緑内障学会緑内障関連遺伝子研究班
Organizer
第70回日本臨床眼科学会
Place of Presentation
国立京都国際会館/グランドプリンスホテル京都(京都府京都市)
Year and Date
2016-11-03
Related Report
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