Elucidation of a destruction mechanism and development of new treatment on intraocular chronic inflammatory diseases with CYP metabolites
| Project/Area Number |
15K10869
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
YANAI Ryoji 山口大学, 医学部附属病院, 講師 (10346554)
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| Co-Investigator(Kenkyū-buntansha) |
園田 康平 九州大学, 医学研究院, 教授 (10294943)
佐古田 幸美 山口大学, 大学院医学系研究科, 講師 (30629754)
折田 朋子 山口大学, 医学部附属病院, 助教 (50467792)
木村 和博 山口大学, 大学院医学系研究科, 教授 (60335255)
寺西 慎一郎 山口大学, 医学部附属病院, 助教 (90649360)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 眼炎症 / 加齢黄斑変性症 / ぶどう膜炎 / オメガ3脂肪酸 / チトクロームP / チトクロームP450 |
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| Outline of Final Research Achievements |
We demonstrate that dietary supplementation of ω-3 LCPUFAs mediate choroidal neovessel regression with leukocyte recruitment and inflammatory reduction in choroidal neovascular lesions. Furthermore, we show that a diet enriched in ω-3 LCPUFAs suppressed uveitis in mice in association with inhibition of Th1 and Th17 cell function. cytochrome P450 (CYP) epoxygenases target the ω-3 double bond, resulting in an accumulation of 17,18-epoxyeicosatetraenoic acid (17,18-EEQ) derived from EPA, one of major ω-3 LCPUFAs.
In current study, we examined the anti-inflammatory properties of these molecules and have shown that 17,18-EEQ suppressed intraocular inflammation, as evaluated both clinically and histologically, in mice with EAU by inhibiting both systemic and retinal Th1 and Th17 cells.
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Report
(4 results)
Research Products
(62 results)
