Study on the molecular mechanism of the role of succinate in intraocular proliferative diseases
| Project/Area Number |
15K10871
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagasaki University |
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Principal Investigator |
KITAOKA Takashi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80234235)
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| Co-Investigator(Kenkyū-buntansha) |
築城 英子 長崎大学, 病院(医学系), 講師 (30363493)
木下 博文 長崎大学, 病院(医学系), 助教 (50530466)
松本 牧子 長崎大学, 医歯薬学総合研究科(医学系), 助教 (70437903)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 眼内増殖性疾患 / 血管内皮増殖因子 / 網膜血流 / コハク酸 / レーザー光凝固 / 網膜 / 毛様体 / 血管新生 / 細胞生存シグナル / 細胞死シグナル |
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| Outline of Final Research Achievements |
In this study, precise mechanism of angiogenesis in the intraocular neovascularization in ischemic and hypertensive environments is studied. The goal is to elucidate the mechanism and develop into future treatment, and the retinal blood flow is measured by Laser speckle flowgraphy. Reduction of VEGF by retinal photocoagulation significantly reduces ocular fundus blood flow and improves the activity of retinal neovascularization.
It is suggested that the possibility to quantify effective retinal photocoagulation by measuring its blood flow decrease the activity of neovascularization.
It is necessary to investigate the involvement of succinate in fundus blood flow.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Optimized Culture System to Induce Neurite Outgrowth From Retinal Ganglion Cells in Three-Dimensional Retinal Aggregates Differentiated From Mouse and Human Embryonic Stem Cells.2016
Author(s)
Maekawa Y, Onishi A, Matsushita K, Koide N, Mandai M, Suzuma K, Kitaoka T, Kuwahara A, Ozone C, Nakano T, Eiraku M, Takahashi M
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Journal Title
Curr Eye Res
Volume: 19
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] NEURITE OUTGROWTH FROM RETINAL GANGLION CELLS IN SELF-ORGANIZING MOUSE AND HUMAN RETINAL TISSUES DIFFERENTIATED FROM EMBRYONIC STEM CELLS.2015
Author(s)
Maekawa Y, Onishi A, Matsushita K, Koide N, Mandai M, Suzuma K, Kitaoka T, Kuwahara A, Ozone C, Nakano T, Eiraku M, Takahashi M
Organizer
ISSCR2015 Annual Meeting
Place of Presentation
Stockholmsm&anml;ssan Exhibition and convention CenterStockholm, Sweden)
Year and Date
2015-06-24
Related Report
Int'l Joint Research
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