Approach for retinal diseases based on regulation of hypoxia response
| Project/Area Number |
15K10881
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 網膜 / 低酸素応答 / 動物モデル / 薬物治療 / 加齢黄斑変性 / 低酸素誘導因子 / HIF |
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| Outline of Final Research Achievements |
To date, hypoxia-inducible factors (HIFs) have been revealed to play an important role in pathogenesis of various diseases. In this study, we generated and evaluated conditional knockout mice for HIFs and their negative regulator VHL. HIF deletion in adult retina induced no abnormal phenotype whereas ectopic HIF stabilization lead retinal degeneration indicating that HIF can be a new therapeutic target for retinal diseases. Furthermore, we administrated HIF inhibitors in animal models of retinal degeneration and confirmed a therapeutic effect against the phenotypes. These results suggested that HIF inhibition can contribute not only for retinal disease treatment but also prevention.
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Report
(4 results)
Research Products
(106 results)
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[Journal Article] Benefits of aflibercept treatment for age-related macular degeneration patients with good best-corrected visual acuity at baseline.2017
Author(s)
Minami S, Nagai N, Suzuki M, Kurihara T, Sonobe H, Kamoshita M, Uchida A, Shinoda H, Takagi H, Sonoda S, Sakamoto T, Tsubota K, Ozawa Y
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Journal Title
Sci Rep.
Volume: 8
Issue: 1
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration.2016
Author(s)
Kurihara T, Westenskow PD, Gantner ML, Usui Y, Schultz A, Bravo S, Aguilar E, Wittgrove C, Friedlander MS, Paris LP, Chew E, Siuzdak G, Friedlander M
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Journal Title
eLife
Volume: 14319
Pages: 1-22
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Global metabolomics reveals metabolic dysregulation in ischemic retinopathy.2016
Author(s)
Paris LP, Johnson CH, Aguilar E, Usui Y, Cho K, Hoang LT, Feitelberg D, Benton HP, Westenskow PD, Kurihara T, Trombley J, Tsubota K, Ueda S, Wakabayashi Y, Patti GJ, Ivanisevic J, Siuzdak G, Friedlander M
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Journal Title
Metabolomics
Volume: 12(1):15
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Neurovascular crosstalk between interneurons and capillaries is required for vision.2015
Author(s)
Usui Y, Westenskow PD, Kurihara T, Aguilar E, Sakimoto S, Paris LP, Wittgrove C, Feitelberg D, Friedlander MS, Moreno SK, Dorrell MI, Friedlander M
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Journal Title
The Journal of Clinical Investigation
Volume: 125(6)
Issue: 6
Pages: 2335-2346
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 低酸素応答に支配される網膜2015
Author(s)
栗原俊英
Organizer
同志社大学先端医工学研究センターセミナー
Place of Presentation
京田辺キャンパス医心館（京都府京田辺市）
Year and Date
2015-06-24
Related Report
Invited
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[Presentation] Light-induced retinal degeneration and AMPK2015
Author(s)
Hirohiko Kawashima, Hideto Osada, Tomohiro Okamoto, Norimitsu Ban, Mamoru Kamoshita, Toshihide Kurihara, Norihiro Nagai, Kazuo Tsubota, Yoko Ozawa
Organizer
ARVO Annual Meeting 2015
Place of Presentation
デンバー（アメリカ合衆国）
Year and Date
2015-05-07
Related Report
Int'l Joint Research
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