| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The aim of this study is to establish a new treatment with photodynamic antimicrobial chemotherapy (PACT) for infectious keratitis.
In this period, we evaluated we evaluated the effectiveness of photodynamic antimicrobial chemotherapy (PACT) with TONS504 on filamentous fungi and Acanthamoeba. TONS504-PACT inhibited the growth of Fusarium. solani. However, there was no inhibitory effect for Aspergillus fumigatus by TONS504-PACT. TONS504-PACT suppressed the viability of Acanthamoeba through apoptosis and necrosis in vitro.
We have started to evaluate the in vivo effectiveness of TONS504-PACT. PACT with TONS504 attenuated the development of corneal infection with S. aureus in a rabbit model in vivo, with repeated application of PACT improving its efficacy.
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