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Clinical application of photodynamic antimicrobial chemotherapy for infectious keratitis

Research Project

Project/Area Number 15K10894
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionHiroshima University

Principal Investigator

Chikama Taiichiro  広島大学, 医歯薬保健学研究科(医), 准教授 (00263765)

Co-Investigator(Kenkyū-buntansha) 高 知愛  広島大学, 医歯薬保健学研究科(医), 准教授 (70314797)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords光線力学療法 / 角膜感染症 / 抗病原微生物 / 薬剤耐性 / 多剤耐性 / 抗微生物
Outline of Final Research Achievements

The aim of this study is to establish a new treatment with photodynamic antimicrobial chemotherapy (PACT) for infectious keratitis.
In this period, we evaluated we evaluated the effectiveness of photodynamic antimicrobial chemotherapy (PACT) with TONS504 on filamentous fungi and Acanthamoeba. TONS504-PACT inhibited the growth of Fusarium. solani. However, there was no inhibitory effect for Aspergillus fumigatus by TONS504-PACT. TONS504-PACT suppressed the viability of Acanthamoeba through apoptosis and necrosis in vitro.
We have started to evaluate the in vivo effectiveness of TONS504-PACT. PACT with TONS504 attenuated the development of corneal infection with S. aureus in a rabbit model in vivo, with repeated application of PACT improving its efficacy.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2018 2017 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Journal Article] Time-dependent antimicrobial effect of photodynamic therapy with TONS 504 on Pseudomonas aeruginosa2018

    • Author(s)
      Sueoka K, Chikama T, Latief MA, Ko JA, Kiuchi Y, Sakaguchi T, Obana A
    • Journal Title

      Lasers in Medical Science

      Volume: - Issue: 7 Pages: 1455-1460

    • DOI

      10.1007/s10103-018-2490-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antimicrobial action from a novel porphyrin derivative in photodynamicantimicrobial chemotherapy in vitro.2015

    • Author(s)
      Latief MA, Chikama T, Shibasaki M, Sasaki T, Ko JA, Kiuchi Y, Sakaguchi T, Obana A.
    • Journal Title

      Lasers Med Sci.

      Volume: 30 Pages: 383-387

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Inactivation of acyclovir-sensitive and -resistant strains of herpes simplex virus type 1 in vitro by photodynamic antimicrobial chemotherapy.2015

    • Author(s)
      Latief MA, Chikama T, Ko JA, Kiuchi Y, Sakaguchi T, Obana A.
    • Journal Title

      Mol Vis.

      Volume: 21 Issue: 1 Pages: 532-537

    • DOI

      10.1007/s10103-014-1681-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 角膜感染症に対する光線力学的抗微生物化学療法(PACT)2018

    • Author(s)
      末岡健太郎
    • Organizer
      角膜カンファランス2018
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Efficacy of Photodynamic Antimicrobial Therapy with TONS504 on Acanthamoeba2018

    • Author(s)
      Pertiwi YD,近間泰一郎,末岡健太郎,高知愛,木内良明,坂口剛正
    • Organizer
      角膜カンファランス2018
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糸状真菌に対する光線力学的抗微生物化学療法の効果2017

    • Author(s)
      近間泰一郎,末岡健太郎,高知愛,坂口剛正,木内良明
    • Organizer
      角膜カンファランス2017
    • Place of Presentation
      福岡
    • Year and Date
      2017-02-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 家兎黄色ブドウ球菌角膜感染モデルに対する光線力学的抗微生物化学療法の効果2017

    • Author(s)
      末岡健太郎,近間泰一郎,高知愛,木内良明,坂口剛正
    • Organizer
      第121回日本眼科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Antimicrobial efficacy ofphotodynamic therapy with TONS504 againstpathogenic filamentous fungi2017

    • Author(s)
      Chikama T, Sueoka K, Ko JA, Kiuchi Y, Sakaguchi T, Obana A
    • Organizer
      ARVO 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 緑膿菌に対する光線力学的抗微生物化学療法の経時的効果2017

    • Author(s)
      末岡健太郎, 近間泰一郎、高 知愛、木内良明、坂口剛正、尾花 明、阪田 功、市川 晶
    • Organizer
      第27回日本光線力学学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糸状真菌に対する光線力学的抗微生物化学療法の効果2016

    • Author(s)
      近間泰一郎,末岡健太郎,高知愛,坂口剛正,木内良明
    • Organizer
      第20回眼創傷治癒研究会
    • Place of Presentation
      福岡
    • Year and Date
      2016-08-20
    • Related Report
      2016 Research-status Report
  • [Presentation] in vitroでのPACTの経時的効果および複数回のPACT施行による抗微生物効果の増強2016

    • Author(s)
      末岡健太郎,近間泰一郎,高知愛,坂口剛正,木内良明
    • Organizer
      第20回眼創傷治癒研究会
    • Place of Presentation
      福岡
    • Year and Date
      2016-08-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 緑膿菌に対する光線力学的抗微生物化学療法の経時的効果2016

    • Author(s)
      末岡健太郎,近間泰一郎, Miftahul Akhyar Latief,高知愛,木内良明
    • Organizer
      第53回日本眼感染症学会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-01
    • Related Report
      2016 Research-status Report
  • [Presentation] Temporal antimicrobial effect of photodynamic therapy with TONS504 on Pseudomonas aeruginosa2016

    • Author(s)
      Kentaro Sueoka, Taiichiro Chikama, Miftahul Akhyar Latief, Ji-ae Ko, Yoshiaki Kiuchi, Akira Obana
    • Organizer
      ARVO 2016
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2016-05-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 感染症に対する光線力学的抗微生物化学療法2016

    • Author(s)
      近間泰一郎
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2016-04-07
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] TONS504を用いた光線力学療法(PDT)のin vitroにおける抗菌および抗ウイルス効果―角膜感染症に対する新規治療法の開発を目指して―2015

    • Author(s)
      近間泰一郎
    • Organizer
      第25回日本光線力学学会学術講演会
    • Place of Presentation
      東京都新宿区
    • Year and Date
      2015-07-11
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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