| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Neuromedin U (NmU)－/－ and NmU+/+ mice were immunized with human interphotoreceptor retinoid binding protein peptide 1-20 (IRBP) to induce EAU. Histological analysis revealed a significant induction of cellular infiltration into the retina in NmU－/－ mice on day 21, correlated with increased gene expression of proinflammatory cytokines, including interferon-γ and interleukin-17. On the other hand, Th1 and Th17 cell responses were reduced in NmU－/－ mice. Immunohistochemical analysis showed that NmU receptor 1 was expressed in retinal pigment epithelial (RPE) and ciliary epithelial cells, and Muller cells, whereas Nmu receptor 2 in RPE and ciliary epithelial cells. These results suggested that NmU provides EAU restraint through participation of RPE in the eye.
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