Analysis of roles of neuromedin U in experimental autoimmune uveitis
Project/Area Number |
15K10896
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
木村 和博 山口大学, 大学院医学系研究科, 教授 (60335255)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | ぶどう膜炎 / Tリンパ球 / 網膜色素上皮細胞 / 神経ペプチド / 炎症 / 免疫抑制 / T細胞 |
Outline of Final Research Achievements |
Neuromedin U (NmU)-/- and NmU+/+ mice were immunized with human interphotoreceptor retinoid binding protein peptide 1-20 (IRBP) to induce EAU. Histological analysis revealed a significant induction of cellular infiltration into the retina in NmU-/- mice on day 21, correlated with increased gene expression of proinflammatory cytokines, including interferon-γ and interleukin-17. On the other hand, Th1 and Th17 cell responses were reduced in NmU-/- mice. Immunohistochemical analysis showed that NmU receptor 1 was expressed in retinal pigment epithelial (RPE) and ciliary epithelial cells, and Muller cells, whereas Nmu receptor 2 in RPE and ciliary epithelial cells. These results suggested that NmU provides EAU restraint through participation of RPE in the eye.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Long-term efficacy of infliximab treatment and the predictors of treatment outcomes in patients with refractory uveitis associated with Behcet’s disease.2018
Author(s)
(1)Ueda S, Akahoshi M, Takeda A, Inoue Y, Omoto A, Ayano M, Kimoto Y, Mitoma H, Arinobu Y, Niiro H, Tsukamoto H, Horiuchi T, Hikita SI, Fukuhara T, Ishibashi T, Sonoda KH, Akashi K
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Journal Title
Eur J Rheumatol
Volume: 5
Issue: 1
Pages: 9-15
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Internal limiting membrane peeling-dependent retinal structural changes after vitrectomy in rhegmatogenous retinal detachment.2017
Author(s)
Hisatomi T, Tachibana T, Notomi S, Koyanagi Y, Murakami Y, Takeda A, Ikeda Y, Yoshida S, Enaida H, Murata T, Sakamoto T,Sonoda KH, Ishibashi T:
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Journal Title
Retina
Volume: 38(3)
Issue: 3
Pages: 471-479
DOI
Related Report
Peer Reviewed
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[Journal Article] Investigation of the association between IL10 gene polymorphisms and Vogt-Koyanagi-Harada disease in a Japanese population.2016
Author(s)
Kaori Higashia, Akira Meguroa, Masaki Takeuchiab, Takahiro Yamanea, Nobuyoshi Kitaichic, Yukihiro Horiec, Kenichi Nambad, Shigeaki Ohnod, Kumiko Nakaoe, Taiji Sakamotoe, at el.
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Journal Title
Ophthalmic Genetics
Volume: -
Issue: 2
Pages: 187-189
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] High-Resolution imaging by adaptive optics scanning laser ophthalmoscopy reveals two morphological distinct types of retinal hard exudates.2016
Author(s)
Yamaguchi M, Nakao S, Kaizu Y, Kobayashi Y, Nakama T, Arima M, Yoshida S, Oshima Y, Takeda A, Ikeda Y, Mukai S, Ishiabshi T, Sonoda KH.
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Journal Title
Sci Rep
Volume: 19
Issue: 1
Pages: 35127-35127
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Distinct profiles of soluble cytokine receptors between B-cell vitreoretinal lymphoma and uveitis.2015
Author(s)
Takeda A, Yoshikawa H, Fukuhara T, Hikita S, Otomo T, Arita R, Oshima Y, Hisatomi T, Kimura K, Yoshida S, Kawano Y, Sonoda KH, Ishibashi T
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Journal Title
Investigative Ophthalmology Visual Science
Volume: 56
Issue: 12
Pages: 7516-7523
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 眼内悪性リンパ腫と可溶型IL-2受容体との関連について2016
Author(s)
武田篤信, 吉川洋, 有田量一, 肱岡邦明, 疋田伸一, 清武良子, 木村和博, 吉田茂生, 川野庸一, 石橋達朗, 園田康平
Organizer
第70回日本臨床眼科学会
Place of Presentation
京都府京都市
Year and Date
2016-11-03
Related Report
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[Presentation] 網膜線維瘢痕化とIL-62016
Author(s)
長谷川英一, 佐藤孝太, 武田篤信, 大島裕司, 中澤徹, 趙英準, 園田康平
Organizer
第50回日本眼炎症学会
Place of Presentation
東京都
Year and Date
2016-07-01
Related Report
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