Comprehensive research for development of drugs and instruments aiming for safer vitrectomy surgery

• Project/Area Number: 15K10897
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Saga University
• Principal Investigator: Enaida Hiroshi 佐賀大学, 医学部, 教授 (00363333)
• Co-Investigator(Renkei-kenkyūsha): ISHIBASHI Tatsuro 九州大学病院, 病院長 (30150428)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ブリリアントブルーG / BBG / 内境界膜染色 / 水晶体前嚢染色 / 視認性改善 / 消炎効果 / 医師主導治験 / 機器開発 / 抗炎症作用 / 手術用観察システム / 広角観察システム / シャープカットフィルター / 手術機器 / P2X7アンタゴニスト

Outline of Final Research Achievements

We have planned and carried out a new doctor-initiated trial for Brilliant Blue G (BBG) aiming at expanding adaptation for staining of the anterior lens capsule during refractory cataract surgery. We will prepare a summary report together with the result of internal limiting membrane staining for this result and are planning to apply to PMDA as soon as possible.Furthermore, as a nonclinical study, we examined the anti-inflammatory effect of BBG for experimental uveitis and got good results.Regarding equipment development, we developed a new observation system that can be used in conjunction with the actual wide-viewing system by developing the research result of the improvement effect of BBG's intraoperative visibility.

Research Products

• [Journal Article] Crucial role of P2X7 receptor for effector T cell activation in experimental autoimmune uveitis (2018)
  • Author(s): Takeda A，Yamada H，Hasegawa E，Arima M，Notomi S，Myojin S，Yoshimura T，Hisatomi T，Enaida H，Yanai R，Kimura K，Ishibashi T，Sonoda KH
  • Journal Title: Jpn J Ophthalmol Volume: - Issue: 3 Pages: 398-406
  • DOI: 10.1007/s10384-018-0587-4
  • NAID: 40021544712
  • Peer Reviewed / Open Access
• [Journal Article] 特集 網膜硝子体手術の新しいスタイル 補助剤(アジュバント)の進化 (2017)
  • Author(s): 江内田寛
  • Journal Title: 臨床眼科 Volume: 71 Issue: 13 Pages: 1840-1848
  • DOI: 10.11477/mf.1410212531
  • ISSN: 0370-5579, 1882-1308
  • Year and Date: 2017-12-15
  • Peer Reviewed
• [Journal Article] Internal limiting membrane peeling-dependent retinal structural changes after vitrectomy in rhegmatogenous retinal detachment. (2017)
  • Author(s): Hisatomi T, Tachibana T, Notomi S, Koyanagi Y, Murakami Y, Takeda A, Ikeda Y, Yoshida S, Enaida H, Murata T, Sakamoto T,Sonoda KH, Ishibashi T:
  • Journal Title: Retina Volume: 38（3） Issue: 3 Pages: 471-479
  • DOI: 10.1097/iae.0000000000001558
  • Peer Reviewed
• [Journal Article] 組織可視化のための硝子体手術補助剤の変遷と現状（総説） (2017)
  • Author(s): 江内田寛
  • Journal Title: 日本眼科学会雑誌 Volume: 121 Pages: 789-802
  • Peer Reviewed
• [Journal Article] INCOMPLETE REPAIR OF RETINAL STRUCTURE AFTER VITRECTOMY WITH INTERNAL LIMITING MEMBRANE PEELING (2016)
  • Author(s): Hisatomi T, Tachibana T, Notomi S, Nakatake S, Fujiwara K, Murakami Y, Ikeda Y, Yoshida S, Enaida H, Murata T, Sakamoto T, Sonoda KH, Ishibashi T.
  • Journal Title: Retina Volume: Epub ahead of print Issue: 8 Pages: 0-0
  • DOI: 10.1097/iae.0000000000001388
  • Peer Reviewed
• [Journal Article] Investigation of the association between IL10 gene polymorphisms and Vogt-Koyanagi-Harada disease in a Japanese population. (2016)
  • Author(s): Kaori Higashia, Akira Meguroa, Masaki Takeuchiab, Takahiro Yamanea, Nobuyoshi Kitaichic, Yukihiro Horiec, Kenichi Nambad, Shigeaki Ohnod, Kumiko Nakaoe, Taiji Sakamotoe, at el.
  • Journal Title: Ophthalmic Genetics Volume: - Issue: 2 Pages: 187-189
  • DOI: 10.3109/13816810.2016.1145698
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Changes in chorioretinal blood flow velocity and cerebral blood flow after carotid endarterectomy. (2016)
  • Author(s): Enaida H, Nagata S, Takeda A, Nakao S, Ikeda Y, Ishibashi T.
  • Journal Title: Jpn J Ophthalmol. Volume: 60 Issue: 6 Pages: 459-465
  • DOI: 10.1007/s10384-016-0472-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A0001（ブリリアントブルーG250）の内境界膜染色と剝離に対する有効性と安全性の検討・多施設共同第III相医師主導治験. (2016)
  • Author(s): 江内田 寛, 平形 明人, 大路 正人, 西田 幸二, 久保田 敏昭, 緒方 奈保子, 園田 康平, 内山 麻希子, 岸本 淳司, 戸高 浩司, 中西 洋一, 石橋 達朗.
  • Journal Title: 日眼会誌. Volume: 120 Pages: 439-448
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Wide-field laser ophthalmoscopy for imaging of gas-filled eyes after macular hole surgery. (2016)
  • Author(s): Nakao S, Arita R, Sato Y, Enaida H, Ueno A, Matsui T, Salehi-Had H, Ishibashi T, Sonoda KH.
  • Journal Title: Clin Ophthalmol. Volume: 10 Pages: 1623-1630
  • DOI: 10.2147/opth.s109900
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A0001（ブリリアントブルーG 250）の内境界膜染色と剥離に対する有効性と安全性の検討―多施設共同第III相医師主導治験 (2016)
  • Author(s): 江内田寛 他
  • Journal Title: 日本眼科学会雑誌 Volume: 6
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Long-term Surgical Outcomes of Epiretinal Membrane in Patients with Retinitis Pigmentosa. (2015)
  • Author(s): Ikeda Y, Yoshida N, Murakami Y, Nakatake S, Notomi S, Hisatomi T, Enaida H, Ishibashi T.
  • Journal Title: Sci Rep. Volume: 13 Issue: 1
  • DOI: 10.1038/srep13078
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Astrocyte-mediated ischemic tolerance. (2015)
  • Author(s): Hirayama Y, Ikeda-Matsuo Y, Notomi S, Enaida H, Kinouchi H, Koizumi S.
  • Journal Title: J Neurosci. Volume: 35 Pages: 3794-3805
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration (2015)
  • Author(s): Zandi S, Nakao S, Chun K H, Fiorina P, Sun D, Arita R, Zhao M, Kim E, Schueller O, Campbell S, Taher M, Melhorn M I, Schering A, Gatti F, Tezza S, Xie F, Vergani A, Yoshida S, Ishikawa K, Yamaguchi M, Sasaki F, Schmidt-Ullrich R, Hata Y, Enaida H, Yuzawa M, Yokomizo T, 4名
  • Journal Title: Cell Rep Volume: 10 Issue: 7 Pages: 1173-86
  • DOI: 10.1016/j.celrep.2015.01.050
  • Peer Reviewed / Open Access
• [Journal Article] Correlation between macular blood flow and central visual sensitivity in retinitis pigmentosa. (2015)
  • Author(s): Murakami Y, Ikeda Y, Akiyama M, Fujiwara K, Yoshida N, Nakatake S, Notomi S, Nabeshima T, Hisatomi T, Enaida H, Ishibashi T.
  • Journal Title: Acta Ophthalmol. Volume: 93 Issue: 8
  • DOI: 10.1111/aos.12693
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Intraoperative findings of inverted internal limiting membrane flap (2017)
  • Author(s): Mine T, Enaida H.
  • Organizer: The 2nd Taiwan-Japan Vitreoretinal Joint Meeting.
  • Int'l Joint Research / Invited
• [Presentation] 硝子体手術用マイクロ鑷子の開発と医療器機開発のしくみ (2016)
  • Author(s): 江内田寛
  • Organizer: 第５５回日本網膜硝子体学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-12-02
  • Invited
• [Presentation] 眼底酸素飽和度測定の開発（その1）～機器構成と測定のしくみ～ (2015)
  • Author(s): 江内田寛
  • Organizer: Japan Macula Club
  • Place of Presentation: 愛知県蒲郡市
  • Year and Date: 2015-08-22
  • Invited
• [Book] 今日の治療指針2017 「飛蚊症」 (2017)
  • Author(s): 江内田 寛
  • Total Pages: 1999
  • Publisher: 医学書院
  • ISBN: 9784260028080
• [Book] 眼科疾患最新の治療 2016-2018 （黄斑上膜） (2016)
  • Author(s): 江内田寛（分担）
  • Total Pages: 323
  • Publisher: 南江堂
• [Book] 眼科研修ノート 改訂第2版 「自身の研究成果を臨床応用（実用化）するには」 (2015)
  • Author(s): 江内田寛 （分担）
  • Total Pages: 586
  • Publisher: 診断と治療社