Identification of mechanisms underlying ectopic hyaloid invasion into retina in PHPV
Project/Area Number |
15K10898
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Nagoya City University |
Principal Investigator |
Yoshida Munenori 名古屋市立大学, 大学院医学研究科, 准教授 (60273447)
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Co-Investigator(Kenkyū-buntansha) |
植村 明嘉 名古屋市立大学, 大学院医学研究科, 教授 (30373278)
小椋 祐一郎 名古屋市立大学, 大学院医学研究科, 教授 (70191963)
|
Co-Investigator(Renkei-kenkyūsha) |
FUKUSHIMA Yoko 大阪大学, 医学系研究科, 助教 (70647031)
NISHIYAMA Koichi 熊本大学, 国際先端医学研究機構, 准教授 (80398221)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | PHPV / 硝子体血管 / 網膜 / 内皮細胞 / Sema3E / PlexinD1 / RhoJ / 第一次硝子体過形成遺残 |
Outline of Final Research Achievements |
In persistent hyperplastic primary vitreous (PHPV), remaining hyaloid vessels often adhere to retinal surfaces. We previously found that in semaphorin 3E (Sema3E) knockout mice, hyaloid vessels ectopically invaded into retinas, leading to the formation of retinal folds (Fukushima et al. J Clin Invest 2011). In this research project, Sema3E derived from retinal ganglion cells bound to PlexinD1 on the endothelial cell surfaces of hyaloid vessels and activated a small GTPase RhoJ, thereby preventing ectopic hyaloid invasion into the retina.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown2017
Author(s)
Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro-Oonuma T, Hwang Y, Ahn S, Park I, Ikeda W, Kusuhara S, Fukushima Y, Nara H, Sakai H, Fujiwara T, Matsushita J, Ema M, Hirashima M, Minami T, Shibuya M, Takakura N, Kim P, Miyata T, Ogura Y, Uemura A
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Journal Title
JCI Insight
Volume: 2
Issue: 3
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A multicenter randomized controlled study of antioxidant supplementation with lutein for chronic central serous chorioretinopathy.2017
Author(s)
Shinojima A, Sawa M, Sekiryu T, Oshima Y, Mori R, Hara C, Sugano Y, Kato A, Asato H, Yuzawa M, Gomi F, Ogura Y, Ishibashi T, Nanri T, Yasukawa T.
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Journal Title
Ophthalmologica
Volume: 237
Issue: 3
Pages: 159-166
DOI
Related Report
Peer Reviewed
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