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The effect of corneal and conjunctival epithelial wound healing through the parasympathetic nerve protection and repairing by neurotropic factor

Research Project

Project/Area Number 15K10904
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionJuntendo University

Principal Investigator

Toshida Hiroshi  順天堂大学, 医学部, 先任准教授 (00306961)

Co-Investigator(Kenkyū-buntansha) 須藤 史子  東京女子医科大学, 医学部, 准教授 (30246467)
藤巻 拓郎  順天堂大学, 医学部, 非常勤講師 (50333042)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords副交感神経 / ドライアイ / 角結膜上皮 / 涙腺 / 除神経 / 神経栄養因子 / 神経再生 / 眼科学
Outline of Final Research Achievements

Lacrimation from main lacrimal gland (LG) is mainly innervated by parasympathetic nerve. Injury of the nerve leads to decrease tear flow and damage in corneal and conjunctival epithelia. We have studied possibility that recovering from decreased tear fluid secretion and corneal and conjunctival epithelia through regeneration of the nerve using a parasympathetic denervated rabbit model.
Retrograde dye tracing study was performed to confirm that the most innervated ganglia was the pterygopalatine ganglion in parasympathetic nervous system on the same side.
As glial cell line-derived neurotrophic factor (GDNF), one of neurotropic factor, we have treated with GDNF in the surgical area, but few remarkable change were shown in the tear fluid secretion and a corneal and conjunctival findings.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Effect of 2% rebamipide ophthalmic suspension in dry eye rabbit model2016

    • Author(s)
      Hiroshi Toshida, Toshihiko Ohta, Chikako Suto, Koichiro Shinji, Maria Karasawa, Akira Murakami
    • Organizer
      The association for Research in Vision and Ophthalmology
    • Place of Presentation
      米国ワシントン州シアトル
    • Year and Date
      2016-05-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 副交感神経除神経家兎ドライアイモデルにおけるレバミピド点眼液の角結膜所見改善効果2016

    • Author(s)
      土至田 宏、太田俊彦、須藤史子、宍道紘一郎、唐澤真里亜、村上 晶
    • Organizer
      第40回日本角膜学会総会
    • Place of Presentation
      長野県
    • Year and Date
      2016-02-18
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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