| Project/Area Number |
15K10905
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Yasuno Yoshiaki 筑波大学, 医学医療系, 教授 (10344871)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 光干渉断層計 / 黄斑疾患 / メラニン / 網膜色素上皮 / 脈絡膜 / 偏光画像 / 血流画像 / 加齢黄斑変性 / ぶどう膜炎 / 偏光 / 血流 / 網脈絡膜 |
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| Outline of Final Research Achievements |
In this project, we used multifunctional optical coherence tomography (OCT), that is a combination of polarization sensitive OCT and OCT angiography, to evaluate the three dimensional distribution of chorioretinal melanin in vivo human eyes. 1) We conducted objective measurement of choroidal melanin contents and established the objective diagnostic methods of sunset glow fundus appearance in Vogt-Koyanagi-Harada disease. 2) We evaluated intraretinal migration of retinal pigment epithelial cells in age related macular degeneration and confirmed origin of the clinical retinal autofluoresceine image. From these study, we confirmed the clinical usefulness of multifunctional OCT for retinal disease.
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