Multi-functional imaging for macular disease
Project/Area Number |
15K10905
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Tokyo Medical University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
Yasuno Yoshiaki 筑波大学, 医学医療系, 教授 (10344871)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 光干渉断層計 / 黄斑疾患 / メラニン / 網膜色素上皮 / 脈絡膜 / 偏光画像 / 血流画像 / 加齢黄斑変性 / ぶどう膜炎 / 偏光 / 血流 / 網脈絡膜 |
Outline of Final Research Achievements |
In this project, we used multifunctional optical coherence tomography (OCT), that is a combination of polarization sensitive OCT and OCT angiography, to evaluate the three dimensional distribution of chorioretinal melanin in vivo human eyes. 1) We conducted objective measurement of choroidal melanin contents and established the objective diagnostic methods of sunset glow fundus appearance in Vogt-Koyanagi-Harada disease. 2) We evaluated intraretinal migration of retinal pigment epithelial cells in age related macular degeneration and confirmed origin of the clinical retinal autofluoresceine image. From these study, we confirmed the clinical usefulness of multifunctional OCT for retinal disease.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Polarization-Sensitive Optical Coherence Tomographic Documentation of Choroidal Melanin Loss in Chronic Vogt-Koyanagi-Harada Disease2017
Author(s)
Miura M, Makita S, Yasuno Y, Tsukahara R, Usui Y, Rao NA, Ikuno Y, Uematsu S, Agawa T, Iwasaki T, Goto H.
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 58
Issue: 11
Pages: 4467-4476
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Polarization sensitive optical coherence tomographic documentation of choroidal melanin loss in chronic Vogt-Koyanagi-Harada disease2017
Author(s)
Miura M, Makita S, Yasuno Y, Tsukahara T, Usui Y, Rao NA, Ikuno Y, Uematsu S, Agawa T, Iwasaki T, Goto H
Organizer
Annual meeting of Association for Research in Visual Science and Ophthalmology
Related Report
Int'l Joint Research
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[Presentation] 偏光感受型OCTによるVogt―小柳―原田病における脈絡膜メラニン障害の定量分析2017
Author(s)
三浦雅博, 巻田修一, 安野嘉晃, 塚原林太郎, 臼井嘉彦, Narsing A Rao, 生野恭司, 植松聡, 阿川哲也, 岩崎琢也, 後藤浩
Organizer
第56回日本網膜硝子体学会総会
Related Report
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[Presentation] Accurate and quantitative polarization-sensitive OCT by unbiased birefringence estimator with noise-stochastic correction2016
Author(s)
D Kasaragod, S Sugiyama, Y Ikuno, DA Caneiro, M Yamanari, S Fukuda , T Oshika, YJ Hong, E Li, S Makita, M Miura, Y Yasuno
Organizer
Photonic West BiOS
Place of Presentation
San Francisco, USA
Year and Date
2016-02-13
Related Report
Int'l Joint Research
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[Presentation] Maximum-a-posteriori birefringence estimator for polarization-sensitive optical coherence tomography2015
Author(s)
D Kasaragod, S Sugiyama, Y Ikuno, DA Caneiro, M Yamanari, S Fukuda , T Oshika, YJ Hong, E Li, S Makita, M Miura, Y Yasuno
Organizer
Optics & Photonics Japan
Place of Presentation
東京都文京区
Year and Date
2015-10-28
Related Report
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