| Project/Area Number |
15K10906
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
栗原 俊英 慶應義塾大学, 医学部, 助教 (50365342)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 角膜移植 / 慢性炎症 / サイトカイン / バイオマーカー / 前房水 / 角膜内皮細胞 / 炎症 / 拒絶反応 |
|---|
| Outline of Final Research Achievements |
We characterized the cytokine elevation patterns in the aqueous humor (AqH) of virous kind corneal diseases in different patterns, suggesting the disease-specific pathological inflammatory responses in different corneal diseases, such as pseudophakic bullous keratopathy (PBK), laser iridotomy and Fuchs endothelial dystrophy (FED). Furthermore, we demonstrated that preoperative specific cytokine levels were associated with the rapid reduction of corneal endothelial cell density (CECD) after corneal transplantation. Collectively, our results suggested that the chronic inflammatory response in the AqH leads to CECD loss. In future studies, we will develop the diagnostic and therapeutic system based on the AqH condition, which we believe will improve the prognosis of corneal transplatation.
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